Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Barbara S. Nikolajczyk"'
Autor:
Edric Winford, Jenny Lutshumba, Barbara J. Martin, Donna M. Wilcock, Gregory A. Jicha, Barbara S. Nikolajczyk, Ann M. Stowe, Adam D. Bachstetter
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-9 (2024)
Abstract Background and purpose The immune response changes during aging and the progression of Alzheimer’s disease (AD) and related dementia (ADRD). Terminally differentiated effector memory T cells (called TEMRA) are important during aging and AD
Externí odkaz:
https://doaj.org/article/68a660d5831a45ab8e203f9dc8bc266d
Autor:
Rachel Conway, Jack Donato Rockhold, Sara SantaCruz-Calvo, Emelia Zukowski, Gabriella H. Pugh, Hatice Hasturk, Philip A. Kern, Barbara S. Nikolajczyk, Leena P. Bharath
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Obesity promotes the onset and progression of metabolic and inflammatory diseases such as type 2 diabetes. The chronic low-grade inflammation that occurs during obesity triggers multiple signaling mechanisms that negatively affect organismal health.
Externí odkaz:
https://doaj.org/article/3aab8723ae97408e900f326d92f5129e
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Neuroinflammation and the tissue-resident innate immune cells, the microglia, respond and contribute to neurodegenerative pathology. Although microglia have been the focus of work linking neuroinflammation and associated dementias like Alzheimer’s
Externí odkaz:
https://doaj.org/article/b618a08b6f37401db448b5730448069c
Autor:
Rui Liu, Barbara S. Nikolajczyk
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Obesity-associated inflammation stems from a combination of cell-intrinsic changes of individual immune cell subsets and the dynamic crosstalk amongst a broad array of immune cells. Although much of the focus of immune cell contributions to metabolic
Externí odkaz:
https://doaj.org/article/c85e43e79ec548a3ab523b6d247425ed
Autor:
Grace McCambridge, Madhur Agrawal, Alanna Keady, Philip A. Kern, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath
Publikováno v:
Biomolecules, Vol 9, Iss 2, p 79 (2019)
Circulating fatty acids (FAs) increase with obesity and can drive mitochondrial damage and inflammation. Nicotinamide nucleotide transhydrogenase (NNT) is a mitochondrial protein that positively regulates nicotinamide adenine dinucleotide phosphate (
Externí odkaz:
https://doaj.org/article/fb911753e26545418386520413d3194a
Autor:
Gabriella H. Pugh, Sajjad Fouladvand, Sara SantaCruz‐Calvo, Madhur Agrawal, Xiaohua Douglas Zhang, Jin Chen, Philip A. Kern, Barbara S. Nikolajczyk
Publikováno v:
Obesity. 30:1983-1994
Myeloid cells dominate metabolic disease-associated inflammation (metaflammation) in mouse obesity, but the contributions of myeloid cells to the peripheral inflammation that fuels sequelae of human obesity are untested. This study used unbiased appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5c744f7b3f6c178158b2e448e34a90
https://doi.org/10.1002/oby.23528
https://doi.org/10.1002/oby.23528
Autor:
Dequina Nicholas, Elizabeth A Proctor, Forum M Raval, Blanche C Ip, Chloe Habib, Eleni Ritou, Tom N Grammatopoulos, Devin Steenkamp, Hans Dooms, Caroline M Apovian, Douglas A Lauffenburger, Barbara S Nikolajczyk
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170975 (2017)
Numerous studies show that mitochondrial energy generation determines the effectiveness of immune responses. Furthermore, changes in mitochondrial function may regulate lymphocyte function in inflammatory diseases like type 2 diabetes. Analysis of ly
Externí odkaz:
https://doaj.org/article/b133ec24293647c7aa0023d6c157c216
Autor:
Sagar P. Bapat, Caroline Whitty, Cody T. Mowery, Yuqiong Liang, Arum Yoo, Zewen Jiang, Michael C. Peters, Ling-juan Zhang, Ian Vogel, Carmen Zhou, Vinh Q. Nguyen, Zhongmei Li, Christina Chang, Wandi S. Zhu, Annette T. Hastie, Helen He, Xin Ren, Wenli Qiu, Sarah G. Gayer, Chang Liu, Eun Jung Choi, Marlys Fassett, Jarish N. Cohen, Jamie L. Sturgill, Laura E. Crotty Alexander, Jae Myoung Suh, Christopher Liddle, Annette R. Atkins, Ruth T. Yu, Michael Downes, Sihao Liu, Barbara S. Nikolajczyk, In-Kyu Lee, Emma Guttman-Yassky, K. Mark Ansel, Prescott G. Woodruff, John V. Fahy, Dean Sheppard, Richard L. Gallo, Chun Jimmie Ye, Ronald M. Evans, Ye Zheng, Alexander Marson
Publikováno v:
Nature, vol 604, iss 7905
Decades of work have elucidated cytokine signalling and transcriptional pathways that control T cell differentiation and haveled the way to targeted biologic therapies that are effective in a range of autoimmune, allergic and inflammatory diseases. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2437f4952bbe1f222362a7c14dbf448
https://escholarship.org/uc/item/2bv4q0k3
https://escholarship.org/uc/item/2bv4q0k3
Autor:
Jennifer E. Snyder-Cappione, J.J. Lee, Chloe Habib, S. Kim, Jordan Carr, Hatice Hasturk, M. Cleveland, Barbara S. Nikolajczyk, Anna C. Belkina, H.H. Elgaali, Riley M.F. Pihl, M. Azer
Publikováno v:
J Dent Res
Periodontitis (PD) is a common source of uncontrolled inflammation in obesity-associated type 2 diabetes (T2D). PD apparently fuels the inflammation of T2D and associates with poor glycemic control and increased T2D morbidity. New therapeutics are cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d9758de9d9fc616d2f2442bdda3266
https://doi.org/10.1177/0022034520912188
https://doi.org/10.1177/0022034520912188
Autor:
Barbara S. Nikolajczyk, Douglas A. Lauffenburger, Gabriella H Pugh, Katherine H. Thompson, Philip A. Kern, Rui Liu, Erin Tevonian
Publikováno v:
Diabetes
A disparate array of plasma/serum markers provide evidence for chronic inflammation in human prediabetes, a condition that is most closely replicated by standard mouse models of obesity and meta-flammation. These remain largely non-actionable, and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61b687329ee153983d9e75a2ecac35a
https://doi.org/10.2337/figshare.16915180.v2
https://doi.org/10.2337/figshare.16915180.v2