Bringing genetics to heretofore intractable obligate intracellular bacterial pathogens: Chlamydia and beyond.

Autor: Magnus Ölander, Barbara S Sixt

Publikováno v: PLoS Pathogens, Vol 18, Iss 7, p e1010669 (2022)

Externí odkaz: https://doaj.org/article/9b1d719ac11b42d1b4cf053c7230f5c7

Metabolic features of Protochlamydia amoebophila elementary bodies--a link between activity and infectivity in Chlamydiae.

Autor: Barbara S Sixt, Alexander Siegl, Constanze Müller, Margarete Watzka, Anna Wultsch, Dimitrios Tziotis, Jacqueline Montanaro, Andreas Richter, Philippe Schmitt-Kopplin, Matthias Horn

Publikováno v: PLoS Pathogens, Vol 9, Iss 8, p e1003553 (2013)

The Chlamydiae are a highly successful group of obligate intracellular bacteria, whose members are remarkably diverse, ranging from major pathogens of humans and animals to symbionts of ubiquitous protozoa. While their infective developmental stage,

Externí odkaz: https://doaj.org/article/413e6d8ffc4b4cbe84d2a40023d02624

The acetylase activity of Cdu1 protects Chlamydia effectors from degradation to regulate bacterial exit from infected cells

Autor: Robert J. Bastidas, Mateusz Kędzior, Lee Dolat, Barbara S. Sixt, Jonathan N. Pruneda, Raphael H. Valdivia

Many cellular processes are regulated by ubiquitin-mediated proteasomal degradation. Bacterial pathogens can regulate eukaryotic proteolysis through the delivery of proteins with de-ubiquitinating (DUB) activities. The obligate intracellular pathogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0636a3ffe7ff80f6ccc2e4cc48006bf0
https://doi.org/10.7554/elife.87386

The Chlamydia protein CpoS modulates the inclusion microenvironment and restricts the interferon response by acting on Rab35

Autor: Karsten Meier, Lana H. Jachmann, Lucía Pérez, Oliver Kepp, Raphael H. Valdivia, Guido Kroemer, Barbara S. Sixt

The obligate intracellular bacterium Chlamydia trachomatis inserts into the membrane of its vacuole (the inclusion) a family of poorly characterized Inc proteins. While the Inc CpoS was recently revealed as a critical suppressor of host cellular immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::200f03c61a46a99bfa9efe445ee08b58
https://doi.org/10.1101/2022.02.18.481055

Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage

Autor: Fathia Mami-Chouaib, Vincent Cattoir, Guido Kroemer, Mohamed Sassi, Krisztián Papp, Nathalie Labarrière, Valerio Iebba, Valentin Quiniou, Romain Boidot, Zsofia Sztupinszki, Nicola Segata, Ivo G. Boneca, Friedemann Loos, Sylvain Simon, Jacques Bou-Khalil, Richard J. Wheeler, Carlos López-Otín, Andréanne Gagné, Luisa De Sordi, Barbara S. Sixt, Philippe Joubert, Clara-Maria Scarlata, Fabien Lemaitre, Peng Liu, Laurent Debarbieux, Alexander M.M. Eggermont, Paola Nisticò, Didier Raoult, David Klatzmann, Connie P.M. Duong, Belinda Palermo, Lisa Derosa, Maha Ayyoub, Maryam Tidjani Alou, Meriem Messaoudene, B. Escudier, François Ghiringhelli, Aurélie Fluckiger, Gladys Ferrere, Saber Khelaifia, Bertrand Routy, Laurence Albiges, Edoardo Pasolli, Anne Gaëlle Goubet, Zoltan Szallasi, Romain Daillère, István Csabai, Laurence Zitvogel, Fabrice Andre, Francesco Facciolo, Corentin Richard, Catherine Rabu

Publikováno v: Science
Science, 2020, 369 (6506), pp.936-942. ⟨10.1126/science.aax0701⟩
Science, American Association for the Advancement of Science, 2020, 369 (6506), pp.936-942. ⟨10.1126/science.aax0701⟩

International audience; Intestinal microbiota have been proposed to induce commensal-specific memory T cells that cross-react with tumor-associated antigens. We identified major histocompatibility complex (MHC) class I-binding epitopes in the tail le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851eb8345a07e0270dec4ff3975ab1eb
https://www.hal.inserm.fr/inserm-02923397