Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Barbara S Nelson"'
Autor:
Samuel A Kerk, Lin Lin, Amy L Myers, Damien J Sutton, Anthony Andren, Peter Sajjakulnukit, Li Zhang, Yaqing Zhang, Jennifer A Jiménez, Barbara S Nelson, Brandon Chen, Anthony Robinson, Galloway Thurston, Samantha B Kemp, Nina G Steele, Megan T Hoffman, Hui-Ju Wen, Daniel Long, Sarah E Ackenhusen, Johanna Ramos, Xiaohua Gao, Zeribe C Nwosu, Stefanie Galban, Christopher J Halbrook, David B Lombard, David R Piwnica-Worms, Haoqiang Ying, Marina Pasca di Magliano, Howard C Crawford, Yatrik M Shah, Costas A Lyssiotis
Publikováno v:
eLife, Vol 11 (2022)
Mitochondrial glutamate-oxaloacetate transaminase 2 (GOT2) is part of the malate-aspartate shuttle, a mechanism by which cells transfer reducing equivalents from the cytosol to the mitochondria. GOT2 is a key component of mutant KRAS (KRAS*)-mediated
Externí odkaz:
https://doaj.org/article/3f6b7faa3ebf44d494617d12f6cd6c1c
Autor:
Daniel M. Kremer, Barbara S. Nelson, Lin Lin, Emily L. Yarosz, Christopher J. Halbrook, Samuel A. Kerk, Peter Sajjakulnukit, Amy Myers, Galloway Thurston, Sean W. Hou, Eileen S. Carpenter, Anthony C. Andren, Zeribe C. Nwosu, Nicholas Cusmano, Stephanie Wisner, Nneka E. Mbah, Mengrou Shan, Nupur K. Das, Brian Magnuson, Andrew C. Little, Milan R. Savani, Johanna Ramos, Tina Gao, Stephen A. Sastra, Carmine F. Palermo, Michael A. Badgley, Li Zhang, John M. Asara, Samuel K. McBrayer, Marina Pasca di Magliano, Howard C. Crawford, Yatrik M. Shah, Kenneth P. Olive, Costas A. Lyssiotis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The aspartate aminotransaminase GOT1 is important for maintaining redox balance. Here, the authors show that inhibition of GOT1 in pancreatic cancer cells leads to cell death via ferroptosis.
Externí odkaz:
https://doaj.org/article/ed8c3b2903a54147ade49ed6c779e8e5
Autor:
Weihua Zhou, Yangyang Yao, Andrew J. Scott, Kari Wilder-Romans, Joseph J. Dresser, Christian K. Werner, Hanshi Sun, Drew Pratt, Peter Sajjakulnukit, Shuang G. Zhao, Mary Davis, Barbara S. Nelson, Christopher J. Halbrook, Li Zhang, Francesco Gatto, Yoshie Umemura, Angela K. Walker, Maureen Kachman, Jann N. Sarkaria, Jianping Xiong, Meredith A. Morgan, Alnawaz Rehemtualla, Maria G. Castro, Pedro Lowenstein, Sriram Chandrasekaran, Theodore S. Lawrence, Costas A. Lyssiotis, Daniel R. Wahl
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Targeting genotype-independent abnormalities may overcome therapy resistance in glioblastoma despite intratumoral genomic heterogeneity. Here, the authors show that glioblastoma radiation resistance is promoted by purine metabolism and can be overcom
Externí odkaz:
https://doaj.org/article/1b59daa1bcd04cf3a9e4d552dbc954ba
Autor:
Barbara S. Nelson, Lin Lin, Daniel M. Kremer, Cristovão M. Sousa, Cecilia Cotta-Ramusino, Amy Myers, Johanna Ramos, Tina Gao, Ilya Kovalenko, Kari Wilder-Romans, Joseph Dresser, Mary Davis, Ho-Joon Lee, Zeribe C. Nwosu, Scott Campit, Oksana Mashadova, Brandon N. Nicolay, Zachary P. Tolstyka, Christopher J. Halbrook, Sriram Chandrasekaran, John M. Asara, Howard C. Crawford, Lewis C. Cantley, Alec C. Kimmelman, Daniel R. Wahl, Costas A. Lyssiotis
Publikováno v:
Cancer & Metabolism, Vol 8, Iss 1, Pp 1-16 (2020)
Abstract Background Metabolic programs in cancer cells are influenced by genotype and the tissue of origin. We have previously shown that central carbon metabolism is rewired in pancreatic ductal adenocarcinoma (PDA) to support proliferation through
Externí odkaz:
https://doaj.org/article/e08285467c004f0193e607f0286f4ab7
Autor:
Christopher J. Halbrook, Galloway Thurston, Seth Boyer, Cecily Anaraki, Jennifer A. Jiménez, Amy McCarthy, Nina G. Steele, Samuel A. Kerk, Hanna S. Hong, Lin Lin, Fiona V. Law, Catherine Felton, Lorenzo Scipioni, Peter Sajjakulnukit, Anthony Andren, Alica K. Beutel, Rima Singh, Barbara S. Nelson, Fran Van Den Bergh, Abigail S. Krall, Peter J. Mullen, Li Zhang, Sandeep Batra, Jennifer P. Morton, Ben Z. Stanger, Heather R. Christofk, Michelle A. Digman, Daniel A. Beard, Andrea Viale, Ji Zhang, Howard C. Crawford, Marina Pasca di Magliano, Claus Jorgensen, Costas A. Lyssiotis
Publikováno v:
Nature cancer, vol 3, iss 11
Nature Cancer
Nature Cancer
The pancreatic tumor microenvironment drives deregulated nutrient availability. Accordingly, pancreatic cancer cells require metabolic adaptations to survive and proliferate. Pancreatic cancer subtypes have been characterized by transcriptional and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d1d8ab8d7e4958d9992ca11db28b89
https://doi.org/10.1038/s43018-022-00463-1
https://doi.org/10.1038/s43018-022-00463-1
Autor:
Samuel A Kerk, Lin Lin, Amy L Myers, Damien J Sutton, Anthony Andren, Peter Sajjakulnukit, Li Zhang, Yaqing Zhang, Jennifer A Jiménez, Barbara S Nelson, Brandon Chen, Anthony Robinson, Galloway Thurston, Samantha B Kemp, Nina G Steele, Megan T Hoffman, Hui-Ju Wen, Daniel Long, Sarah E Ackenhusen, Johanna Ramos, Xiaohua Gao, Zeribe C Nwosu, Stefanie Galban, Christopher J Halbrook, David B Lombard, David R Piwnica-Worms, Haoqiang Ying, Marina Pasca di Magliano, Howard C Crawford, Yatrik M Shah, Costas A Lyssiotis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c09d5546598866e76a5a9578902c0ae7
https://doi.org/10.7554/elife.73245.sa2
https://doi.org/10.7554/elife.73245.sa2
Autor:
Brandon Nicolay, Amy L. Myers, John M. Asara, Cecilia Cotta-Ramusino, Lin Lin, Johanna Ramos, Christopher J. Halbrook, Scott Campit, Ho-Joon Lee, Joseph Dresser, Alec C. Kimmelman, Ilya Kovalenko, Oksana Mashadova, Lewis C. Cantley, Tina Gao, Zeribe C. Nwosu, Costas A. Lyssiotis, Howard C. Crawford, Daniel R. Wahl, Zachary P. Tolstyka, Daniel M. Kremer, Barbara S. Nelson, Kari Wilder-Romans, Mary A. Davis, Cristovão M. Sousa, Sriram Chandrasekaran
Publikováno v:
Cancer & Metabolism, Vol 8, Iss 1, Pp 1-16 (2020)
Cancer & Metabolism
Cancer & Metabolism
Background Metabolic programs in cancer cells are influenced by genotype and the tissue of origin. We have previously shown that central carbon metabolism is rewired in pancreatic ductal adenocarcinoma (PDA) to support proliferation through a glutama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fddc60cfad376852390f945e41749d
https://doaj.org/article/e08285467c004f0193e607f0286f4ab7
https://doaj.org/article/e08285467c004f0193e607f0286f4ab7
Autor:
Nupur K. Das, Amy L. Myers, Costas A. Lyssiotis, Stephen A. Sastra, Li Zhang, Christopher J. Halbrook, Samuel K. McBrayer, Anthony Andren, Yatrik M. Shah, Michael A. Badgley, Marina Pasca di Magliano, Andrew C. Little, Daniel M. Kremer, John M. Asara, Lin Lin, Kenneth P. Olive, Emily L. Yarosz, Nneka E. Mbah, Milan R. Savani, Sean W. Hou, Nicholas Cusmano, Tina Gao, Zeribe C. Nwosu, Peter Sajjakulnukit, Carmine F. Palermo, Mengrou Shan, Johanna Ramos, Stephanie Wisner, Brian Magnuson, Barbara S. Nelson, Galloway Thurston, Eileen S. Carpenter, Howard C. Crawford, Samuel A. Kerk
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications
Nature communications, vol 12, iss 1
Cancer metabolism is rewired to support cell survival in response to intrinsic and environmental stressors. Identification of strategies to target these adaptions is an area of active research. We previously described a cytosolic aspartate aminotrans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3357e197241e4b91f3d40aa8ef2076
https://doi.org/10.1038/s41467-021-24859-2
https://doi.org/10.1038/s41467-021-24859-2
Autor:
Megan D. Radyk, Barbara S. Nelson, Christopher J. Halbrook, Mengrou Shan, Jonathan Alektiar, Howard C. Crawford, Yatrik M. Shah, Costas A. Lyssiotis
Publikováno v:
Cancer Research. 82:2176-2176
Activating mutations in KRAS reprogram cellular metabolism to support continuous growth, proliferation, and survival in pancreatic cancer. However, there is little information on how KRAS-dependent alterations in metabolism change precancerous states
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0386bbf92b85a615fb4e5270063d8aa
https://doi.org/10.1158/1538-7445.am2022-2176
https://doi.org/10.1158/1538-7445.am2022-2176
Autor:
Marina Pasca di Magliano, Yatrik M. Shah, David B. Lombard, Peter Sajjakulnukit, Stefanie Galbán, Barbara S. Nelson, Amy L. Myers, Sarah E. Ackenhusen, Xiaohua Gao, Zeribe C. Nwosu, Yaqing Zhang, Howard C. Crawford, Christopher J. Halbrook, Jennifer A. Jiménez, Hui-Ju Wen, Lin Lin, David Piwnica-Worms, Samuel A. Kerk, Brandon Chen, Anthony Robinson, Megan T. Hoffman, Li Zhang, Johanna Ramos, Anthony Andren, Nina Steele, Haoqiang Ying, Daniel Long, Galloway Thurston, Samantha Kemp, Costas A. Lyssiotis
The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDA) restricts vascularization and, consequently, access to blood-derived nutrients and oxygen, which impacts tumor growth. Intracellular redox imbalance is another restraint on ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95687ad2e7dbe8eedc6f2a8dbe37ad5e
https://doi.org/10.1101/2020.08.07.238766
https://doi.org/10.1101/2020.08.07.238766