Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Barbara Podobnik"'
Autor:
Sebastjan Kralj, Milan Hodošček, Barbara Podobnik, Tanja Kunej, Urban Bren, Dušanka Janežič, Janez Konc
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
In a survey of novel interactions between an IgG1 antibody and different Fcγ receptors (FcγR), molecular dynamics simulations were performed of interactions of monoclonal antibody involved complexes with FcγRs. Free energy simulations were also pe
Externí odkaz:
https://doaj.org/article/6958fa5073c8416abeb2973a1a3f699c
Publikováno v:
Journal of chemical information and modeling, pp. a-l, 2020.
Journal of Chemical Information and Modeling
Journal of Chemical Information and Modeling
Reduction of the affinity of the fragment crystallizable (Fc) region with immune receptors by substitution of one or a few amino acids, known as Fc-silencing, is an established approach to reduce the immune effector functions of monoclonal antibody t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690e452ab3088b4ebc3a78555efe6509
https://doi.org/10.1021/acs.jcim.9b01198
https://doi.org/10.1021/acs.jcim.9b01198
Autor:
Katja, Glinšek, Lovro, Kramer, Aleksander, Krajnc, Eva, Kranjc, Nina, Pirher, Jaka, Marušič, Leon, Hellmann, Barbara, Podobnik, Borut, Štrukelj, David, Ausländer, Rok, Gaber
Publikováno v:
Biotechnology Journal. 17:2100499
Difficulties in obtaining and maintaining the desired level of the critical quality attributes (CQAs) of therapeutic proteins as well as the pace of the development are major challenges of current biopharmaceutical development. Therapeutic proteins,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0827947dcd6b168365f1a153407e6a56
https://doi.org/10.1002/biot.202100499
https://doi.org/10.1002/biot.202100499
Autor:
Neja Zupanec, M. Bunc, Nada Kraševec, Sabina Berne, Metka Novak, Matej Sova, Branka Korošec, Jure Stojan, Barbara Podobnik, Ljerka Lah, Radovan Komel, Stanislav Gobec, Samo Turk
Publikováno v:
Journal of Applied Microbiology. 116:955-966
Aims: CYP53A15, from the sorghum pathogen Cochliobolus lunatus, is involved in detoxification of benzoate, a key intermediate in aromatic compound metabolism in fungi. Because this enzyme is unique to fungi, it is a promising drug target in fungal pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04042f9958fb5cf990a186f8fbbd00ed
https://doi.org/10.1111/jam.12417
https://doi.org/10.1111/jam.12417
Autor:
Neja Zupanec, Erika Šuligoj, Ljerka Lah, Nada Kraševec, Branka Korošec, Jure Stojan, Barbara Podobnik, Stanislav Gobec, Metka Novak, Samo Turk, Sabina Berne, Radovan Komel
Publikováno v:
Journal of Chemical Information and Modeling. 52:3053-3063
Fungal CYP53 enzymes are highly conserved proteins, involved in phenolic detoxification, and have no homologues in higher eukaryotes, rendering them favorable drug targets. Aiming to discover novel CYP53 inhibitors, we employed two parallel virtual s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2fba33fd9bdbea657fb8d4c8911ed9a
https://doi.org/10.1021/ci3004418
https://doi.org/10.1021/ci3004418
Autor:
Joerg Bohlmann, Radovan Komel, Branka Korošec, Ljerka Lah, Metka Novak, Jure Stojan, Neja Zupanec, Barbara Podobnik, Sabina Berne, Nada Kraševec, Matjaž Vogelsang
Publikováno v:
Molecular Microbiology. 81:1374-1389
Summary Cytochromes P450 (CYPs) catalyse diverse reactions and are key enzymes in fungal primary and secondary metabolism, and xenobiotic detoxification. CYP enzymatic properties and substrate specificity determine the reaction outcome. However, CYP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc358dd7f2871a572cecc043470354ad
https://doi.org/10.1111/j.1365-2958.2011.07772.x
https://doi.org/10.1111/j.1365-2958.2011.07772.x
Autor:
Simona Jevsevar, Jože Grdadolnik, Barbara Podobnik, Vladka Gaberc-Porekar, Irena Fonda, Viktor Menart
Publikováno v:
Biotechnology Progress. 21:632-639
Human granulocyte-colony stimulating factor (hG-CSF), an important biopharmaceutical drug used in oncology, is currently produced mainly in Escherichia coli. Expression of human hG-CSF gene in E. coli is very low, and therefore a semisynthetic, codon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c60e44de60915ff193117ac346c9e2c
https://doi.org/10.1021/bp0497839
https://doi.org/10.1021/bp0497839
Autor:
Spela, Jalen, Vanja, Smilović, Katarina, Fidler, Barbara, Podobnik, Maja, Marušić, Radovan, Komel, Vladka, Gaberc-Porekar, Simona, Jevševar
Publikováno v:
Acta chimica Slovenica. 61(3)
One of the major challenges when analyzing very low amounts of PEGylated proteins is finding a sensitive analytical method. Immunoassays are most frequently used, however, conjugation can partially or completely mask protein epitopes, which can subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a09dea558b797894c4182c73689fe74
https://pubmed.ncbi.nlm.nih.gov/25286218
https://pubmed.ncbi.nlm.nih.gov/25286218
Autor:
Katarina, Fidler, Simona, Jevševar, Tatjana, Milunović, Spela, Skrajnar, Aleš, Premzl, Menči, Kunstelj, Irena, Zore, Barbara, Podobnik, Mateja, Kusterle, Simon, Caserman, Maja, Kenig, Vanja, Smilović, Ladka, Gaberc-Porekar
Publikováno v:
Acta chimica Slovenica. 58(1)
G-CSF successfully prevents chemotherapy-induced neutropenia. Two second-generation drugs with improved therapeutic properties are already available and the development of new forms is still ongoing. For an efficient receptor dimerization two G-CSF m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5f6c0e10d77a3770abcd3f6f6bb3b63
https://pubmed.ncbi.nlm.nih.gov/24061936
https://pubmed.ncbi.nlm.nih.gov/24061936
Autor:
Ljerka, Lah, Barbara, Podobnik, Metka, Novak, Branka, Korošec, Sabina, Berne, Matjaž, Vogelsang, Nada, Kraševec, Neja, Zupanec, Jure, Stojan, Joerg, Bohlmann, Radovan, Komel
Publikováno v:
Molecular microbiology. 81(5)
Cytochromes P450 (CYPs) catalyse diverse reactions and are key enzymes in fungal primary and secondary metabolism, and xenobiotic detoxification. CYP enzymatic properties and substrate specificity determine the reaction outcome. However, CYP-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65a6d158fa441fa137a2df480ad6d1dd
https://pubmed.ncbi.nlm.nih.gov/21810122
https://pubmed.ncbi.nlm.nih.gov/21810122