Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Barbara P. Vistica"'
Autor:
Wambui S Wandu, Cuiyan Tan, Osato Ogbeifun, Barbara P Vistica, Guangpu Shi, Samuel J H Hinshaw, Chengsong Xie, Xi Chen, Dennis M Klinman, Huaibin Cai, Igal Gery
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128906 (2015)
Mutations in LRRK2 are related to certain forms of Parkinson's disease and, possibly, to the pathogenesis of Crohn's disease. In both these diseases inflammatory processes participate in the pathogenic process. LRRK2 is expressed in lymphoid cells an
Externí odkaz:
https://doaj.org/article/d5759c03978d4c24a5912486766dcee2
Autor:
Samuel J. H. Hinshaw, Guangpu Shi, Igal Gery, Chan Zhao, Meifen Zhang, Cuiyan Tan, Barbara P. Vistica, Wambui S. Wandu
Publikováno v:
Cellular Immunology. 290:179-184
Regulatory T-cells (Tregs) are responsible for homeostasis of the immune system, as well as for inhibition of pathogenic autoimmune processes. Induced-(i)-Tregs, can be generated in vitro by activation of CD4 cells in the presence of TGF-β. A common
Autor:
Igal Gery, Lindsey F. Nugent, Cuiyan Tan, Dennis M. Klinman, Barbara P. Vistica, Eric F. Wawrousek, Guangpu Shi
Publikováno v:
The Journal of Immunology. 191:415-423
The interaction between TLRs and their cognate ligands triggers both the innate and adaptive immune systems, and thus can play a pivotal role in the defense against pathogen invasion. This work investigates the differentiation of naive CD4 cells into
Autor:
Barbara P. Vistica, Rachael C. Rigden, Guangpu Shi, Mehak K. Aziz, Eric F. Wawrousek, Rachel R. Caspi, Igal Gery, Jenna D. Lovaas, Cuiyan Tan
Publikováno v:
The Journal of Immunology. 189:1220-1227
Subpopulations of pathogenic or nonpathogenic Th17 cells were reported to develop when presensitized CD4 cells were activated with their target Ag during polarization by either IL-23 or IL-6 and TGF-β, respectively. In this study, we generated two T
Publikováno v:
Cellular Immunology. 271:210-213
Th1 cells are remarkably more susceptible to activation induced cell death than Th17. Here, we compared cultures of these two cell subpopulations for their expression of apoptosis-related molecules when re-exposed to their specific antigen. We also c
Publikováno v:
Journal of Neuroimmunology. 215:43-48
Glatiramer acetate (GA), a synthetic random amino acid copolymer, poly(Y, E, A, K)n, is widely used for treatment of multiple sclerosis. It inhibits experimental autoimmune encephalomyelitis (EAE) in mice by competition with the antigen and by induct
Autor:
Guangpu Shi, Barbara P. Vistica, Chi-Chao Chan, Eric F. Wawrousek, Hongen Yin, Igal Gery, Catherine A. Cox
Publikováno v:
The Journal of Immunology. 180:7414-7422
The role of Th17 lymphocytes in immunopathogenic processes has been well established, but little is known about their basic cell features. In this study, we compared polarized Th1 and Th17 for key biological activities related to pathogenicity and tr
Autor:
Baoying Liu, Yoshiyuki Wakabayashi, Emily L Williams, Ashwin Dhanda, Zhiyu Li, Richard W J Lee, Andrew D. Dick, Wenting Wu, Robert B. Nussenblatt, Sima Hirani, David A. Copland, Lauren P Schewitz-Bowers, William R Tucker, Barbara P. Vistica, Becky L. Conway-Campbell, Jun Zhu, Lai Wei, Ping Chen, Igal Gery, Philippa J P Lait, Shayma Jawad, Nida Sen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(13)
Glucocorticoids remain the cornerstone of treatment for inflammatory conditions, but their utility is limited by a plethora of side effects. One of the key goals of immunotherapy across medical disciplines is to minimize patients' glucocorticoid use.
Autor:
Xi Chen, Huaibin Cai, Osato Ogbeifun, Cuiyan Tan, Guangpu Shi, Barbara P. Vistica, Chengsong Xie, Wambui S. Wandu, Dennis M. Klinman, Samuel J. H. Hinshaw, Igal Gery
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128906 (2015)
PLoS ONE
PLoS ONE
Background Mutations in LRRK2 are related to certain forms of Parkinson’s disease and, possibly, to the pathogenesis of Crohn’s disease. In both these diseases inflammatory processes participate in the pathogenic process. LRRK2 is expressed in ly
Autor:
Guangpu Shi, Igal Gery, Charles E. Egwuagu, Cheng-Rong Yu, Chi-Chao Chan, Barbara P. Vistica, Eric F. Wawrousek, Dennis M. Klinman, Chiaki Fujimoto
Publikováno v:
The Journal of Immunology. 177:6896-6903
Microbial products are assumed to play a major role in triggering pathogenic autoimmunity. Recently accumulated data have shown that these products stimulate the immune system by interacting with TLRs, expressed on APCs. To examine the capacity of va