Výsledky vyhledávání - "Barbara Nunn"

Isolation, Identification and Pharmacokinetic Properties of Human Tissue-Type Plasminogen Activator Species: Possible Localisation of a Clearance Recognition Site

Autor: Barbara Nunn, Jeff H. Robinson, Ian Dodd

Publikováno v: Thrombosis and Haemostasis. 59:523-528

SummaryPurified preparations of recombinant tissue-type plasminogen activator (t-PA) from the recombinant Bowes melanoma cell line TRBM6 were shown to contain multiple species of plasminogen activator. Using a combination of chromatography on Sephade

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4769c6c14197d0f4d7cfa03b22a26d
https://doi.org/10.1055/s-0038-1647527

Zobrazit plný text záznamu

Total and selective desensitisation of human platelets to synthetic platelet activating factor (PAF) : Evidence that extracellular paf does not mediate collagen-induced aggregation

Autor: Barbara Nunn

Publikováno v: Thrombosis Research. 31:657-663

A technique is described that renders human platelets totally insensitive to synthetic PAF. The procedure involves gently mixing human citrated platelet-rich plasma (PRP) with 0.1 microM PAF at room temperature. After 3-5 min, a further addition of 0

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f89d490c9d4d7a305ec01c40ce7507
https://doi.org/10.1016/0049-3848(83)90096-8

Zobrazit plný text záznamu

Collagen-Induced Platelet Aggregation: -Evidence Against the Essential Role of Platelet Adenosine Diphosphate

Autor: Barbara Nunn

Publikováno v: Thrombosis and Haemostasis. 42:1193-1206

SummaryThe hypothesis that platelet ADP is responsible for collagen-induced aggregation has been re-examined. It was found that the concentration of ADP obtaining in human PRP at the onset of aggregation was not sufficient to account for that aggrega

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0e3c05a8ef0b68bfd2958d979266a6c
https://doi.org/10.1055/s-0038-1657015

Zobrazit plný text záznamu

Effect of ticlopidine on human platelet responsiveness ex vivo: Comparison with aspirin

Autor: Barbara Nunn, Robert Lindsay

Publikováno v: Thrombosis Research. 18:807-813

Platelet responsiveness in a variety of tests was measured in seven volunteers twice prior to and once after treatment with ticlopidine (250mg bds for seven days). The drug caused moderate but significant inhibition of both collagen-induced aggregati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1826e9f3951ba134bb4eac7827622da3
https://doi.org/10.1016/0049-3848(80)90203-0

Zobrazit plný text záznamu

Effect of nabumetone (BRL 14777), a new anti-inflammatory drug, on human platelet reactivity ex vivo: comparison with naproxen

Autor: P. D. Chamberlain, Barbara Nunn

Publikováno v: Journal of Pharmacy and Pharmacology. 34:576-579

The effect of nabumetone (BRL 14777) on human platelet reactivity ex vivo was compared with that of naproxen at equitherapeutic doses in the same six subjects. Nabumetone had only a weak and equivocal effect on collagen-induced and second phase aggre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::761cbd85b29900928361f628d59b7b18
https://doi.org/10.1111/j.2042-7158.1982.tb04796.x

Zobrazit plný text záznamu

Some Characteristics of Mouse Platelet Aggregation and a Comparison of the Activity of a Range of Compounds in Mouse and Human Platelet-Rich Plasma in Vitro

Autor: Barbara Nunn

Publikováno v: Thrombosis and Haemostasis. 45:001-005

SummaryCollagen-induced platelet aggregation in mouse citrated platelet-rich plasma (PRP) was associated with 5-hydroxytryptamine (5-HT) release and degranulation. Adenosine 5’-diphosphate (ADP) induced monophasic and reversible aggregation with no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475679c74c08908573079a8ce655acdb
https://doi.org/10.1055/s-0038-1650118

Zobrazit plný text záznamu

Adrenergic neuron blocking properties of (±)-propranolol and (+)-propranolol

Autor: Barbara Nunn, A. M. Barrett

Publikováno v: Journal of Pharmacy and Pharmacology. 22:806-810

The action of (±)-propranolol and (+)-propranolol on the electrical stimulation of adrenergic nerves to smooth muscle has been studied in the isolated ear artery from rabbits and the isolated vas deferens preparation from rats. Both drugs exhibited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::306e7abacc4955bc4572d54b952d2725
https://doi.org/10.1111/j.2042-7158.1970.tb08443.x

Zobrazit plný text záznamu

Further evidence against the validity of using an ADP-removing enzyme system (CP/CPK) for demonstrating the role of secreted ADP in platelet activation

Autor: Paul D. Chamberlain, Barbara Nunn

Publikováno v: Thrombosis research. 30(1)

The ADP-removing enzyme system creatine phosphate-creatine phosphokinase (CP/CPK) selectively inhibited primary aggregation in response to the thromboxane receptor agonist, U46619, in mouse aspirin-treated platelet-rich plasma. Inhibition by CP/CPK h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d887fee754a55782681a2dfac0fb14
https://pubmed.ncbi.nlm.nih.gov/6857606

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání