Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Barbara N. Phenix"'
Publikováno v:
Manual of Molecular and Clinical Lab Immunology. :281-290
Programmed cell death is a normal, physiological event which occurs without inflammation, so nontargeted bystander cells are not harmed. It is the body’s mechanism for eliminating cells which are no longer needed or potentially injurious. The study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f107d53c992ae7832c49358c901d6ba9
https://doi.org/10.1128/9781555815905.ch32
https://doi.org/10.1128/9781555815905.ch32
Autor:
Heather Hardin, Rolf P. G. van Heeswijk, Andrew D. Badley, Joel G.R. Weaver, Bogdan Zurakowski, Valerie L. Sim, Sheng T. Hou, Barbara N. Phenix, Peter J. Wettstein, Guido Kroemer, Catherine Brenner, Aurélien Deniaud, Agathe Tarze, Gary D. Bren, Morgane LeBras, Li Dong, Jessica Lallier, Andre G. Douen, Romano T. Kroemer, Tia C. Moffat, David H. Lynch, Susan X. Jiang, Mario Y. Morin, Steffany A. L. Bennett
Publikováno v:
Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2005, 115, pp.1828-1838
Journal of Clinical Investigation, American Society for Clinical Investigation, 2005, 115, pp.1828-1838
Inhibitors of HIV protease have been shown to have antiapoptotic effects in vitro, yet whether these effects are seen in vivo remains controversial. In this study, we have evaluated the impact of the HIV protease inhibitor (PI) nelfinavir, boosted wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47db10cf4943def6f728cc0681cb874c
https://doi.org/10.1172/jci22954
https://doi.org/10.1172/jci22954
Autor:
Julian J. Lum, Barbara N. Phenix, A. Alam, Peter H. Krammer, Zilin Nie, B. Beckett, Andrew D. Badley, David H. Lynch, R. P. Sekaly
Publikováno v:
Cell Death & Differentiation. 9:1172-1184
Infection of T cells with HIV-1 induces apoptosis and modulates apoptosis regulatory molecules. Similar effects occur following treatment of cells with individual HIV-1 encoded proteins. While HIV-1 protease is known to be cytotoxic, little is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6624ef5078821518ef06c4acd7932c53
https://doi.org/10.1038/sj.cdd.4401094
https://doi.org/10.1038/sj.cdd.4401094
Autor:
Julian J. Lum, Jaime Sanchez-Dardon, Andrew D. Badley, R. Douglas, Barbara N. Phenix, André A. Pilon
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:2687-2691
Inhibition of human immunodeficiency virus type 1 reverse transcriptase (RT) by both nucleoside and nonnucleoside RT inhibitors profoundly inhibits virus replication. Nucleoside RT inhibitors are known to be toxic, but there is little information reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d84dca0e78100e176294c3fa0d1b2880
https://doi.org/10.1128/aac.46.8.2687-2691.2002
https://doi.org/10.1128/aac.46.8.2687-2691.2002
Autor:
Barbara N. Phenix, Andrew D. Badley
Publikováno v:
Biochimie. 84:251-264
HIV infection is inexorably linked with disordered regulation of apoptosis, and consequent alterations in mitochondrial homeostasis, resulting in CD4 T cell death and enhanced susceptibility to opportunistic infections and malignancies. Effective tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91803730b26ce84b1c6f61daaa87794a
https://doi.org/10.1016/s0300-9084(02)01378-0
https://doi.org/10.1016/s0300-9084(02)01378-0
Publikováno v:
APOPTOSIS. 7:295-312
Advances in treatment have transformed the Human Immunodeficiency Virus (HIV) infection from a progressive and ultimately fatal disease to one that can be managed effectively by chronic suppressive antiretroviral therapy. The drugs now used to treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::120714382ff557c45ce1e7803a406421
https://doi.org/10.1023/a:1016168411221
https://doi.org/10.1023/a:1016168411221
Autor:
Barbara N. Phenix, John E. Kim, Jennifer Mihowich, Julian J. Lum, Andrew D. Badley, Jaime Sanchez-Dardon, Keri Jamison, André A. Pilon, Nanci Hawley-Foss, David H. Lynch
Because the persistence of human immunodeficiency virus (HIV) in cellular reservoirs presents an obstacle to viral eradication, we evaluated whether tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) induces apoptosis in such reser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef546c5dfedd6497582eee7de90f5ee
https://europepmc.org/articles/PMC114692/
https://europepmc.org/articles/PMC114692/
Publikováno v:
Blood. 98(4)
Treatment of cells with the HIV drugs ritonavir, saquinavir, or nelfinavir (Nfv) inhibits apoptosis induced by a variety of stimuli. Because these drugs are protease inhibitors, they have been postulated to inhibit apoptosis by blocking caspase activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706abedcecc1fe5ada9c1dcd40c4ec65
https://pubmed.ncbi.nlm.nih.gov/11493454
https://pubmed.ncbi.nlm.nih.gov/11493454
Autor:
D. W. Cameron, Barbara N. Phenix, Kelley A. Chambers, Frank Mandy, Stephen Kravcik, Sharon Cassol, Karl Parato, Keith Gallicano, Jonathan B. Angel, Nanci Hawley-Foss, Andrew D. Badley
Publikováno v:
AIDS research and human retroviruses. 16(6)
Antiretroviral treatment of patients infected with HIV results in improvements in CD4+ T cell number. Emerging evidence suggests that some of the improvements in CD4+ T cell number that occur in response to protease inhibitor (PI) therapy may not be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27912b24765bc0a31b27fa4aa02da4d0
https://pubmed.ncbi.nlm.nih.gov/10777146
https://pubmed.ncbi.nlm.nih.gov/10777146
Autor:
Jonathan B. Angel, David H. Lynch, Barbara N. Phenix, Donald William Cameron, D Ashby, Ashok Kumar, Jürg Tschopp, Stephen Kravcik, Karl Parato, Andrew D. Badley
Publikováno v:
Cell death and differentiation. 6(5)
T cells from HIV infected patients undergo spontaneous apoptosis at a faster rate than those from uninfected patients, are abnormally susceptible to activation induced cell death (AICD), and undergo increased apoptosis in response to Fas receptor lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664594ff17dfdaddf42ec5627bcc93c2
https://pubmed.ncbi.nlm.nih.gov/10381636
https://pubmed.ncbi.nlm.nih.gov/10381636