Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Barbara Morschhaeuser"'
Autor:
Floriane Braun, Olaf Kinzel, Simon Anderhub, Martin Hornberger, Gerald Kleymann, Barbara Morschhaeuser, Thomas J. Hoffmann, Sheena Pinto, Christoph Steeneck
Publikováno v:
ACS Med Chem Lett
[Image: see text] Following the impressive success of checkpoint inhibitors in the treatment of cancer, combinations of IDO1 inhibitors with PD-1/PD-L1 antibodies are in clinical development aiming to increase response rates. Using the hydroxyamidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe11b4785cc4e4a5fb28f4b17b6d41b
https://pubmed.ncbi.nlm.nih.gov/32071686
https://pubmed.ncbi.nlm.nih.gov/32071686
Autor:
Christoph Steeneck, Olaf Kinzel, Simon Anderhub, Aurélie Mallinger, Marta Czekańska, Sheena Pinto, Barbara Morschhaeuser, Christina Sonnek, Martin Hornberger, Thomas J. Hoffmann, Michael Albers, Yansong Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 33:127738
Through structural modification of an oxalamide derived chemotype, a novel class of highly potent, orally bioavailable IDO1-specific inhibitors was identified. Representative compound 18 inhibited human IDO1 with IC50 values of 3.9 nM and 52 nM in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373dcfd00c06df0df2fd5d34994a7c3e
https://doi.org/10.1016/j.bmcl.2020.127738
https://doi.org/10.1016/j.bmcl.2020.127738