Výsledky vyhledávání - "Barbara Montico"

Akademický článek

Antibody dependent cellular cytotoxicity-inducing anti-EGFR antibodies as effective therapeutic option for cutaneous melanoma resistant to BRAF inhibitors

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionAbout 50% of cutaneous melanoma (CM) patients present activating BRAF mutations that can be effectively targeted by BRAF inhibitors (BRAFi). However, 20% of CM patients exhibit intrinsic drug resistance to BRAFi, while most of the others

Externí odkaz: https://doaj.org/article/9efcdcc70a744ed59d4d5235c051bf86

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Akademický článek

Autophagy in BRAF-mutant cutaneous melanoma: recent advances and therapeutic perspective

Autor: Elisabetta Fratta, Giorgio Giurato, Roberto Guerrieri, Francesca Colizzi, Jessica Dal Col, Alessandro Weisz, Agostino Steffan, Barbara Montico

Publikováno v: Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)

Abstract Macroautophagy, hereafter referred to as autophagy, represents a highly conserved catabolic process that maintains cellular homeostasis. At present, the role of autophagy in cutaneous melanoma (CM) is still controversial, since it appears to

Externí odkaz: https://doaj.org/article/54b4e8e15f264547853795c1bcd20f91

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Akademický článek

Phospholipid scramblase 1: a protein with multiple functions via multiple molecular interactors

Autor: Jessica Dal Col, Marìa Julia Lamberti, Annunziata Nigro, Vincenzo Casolaro, Elisabetta Fratta, Agostino Steffan, Barbara Montico

Publikováno v: Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-15 (2022)

Abstract Phospholipid scramblase 1 (PLSCR1) is the most studied protein of the scramblase family. Originally, it was identified as a membrane protein involved in maintaining plasma membrane asymmetry. However, studies conducted over the past few year

Externí odkaz: https://doaj.org/article/0d611a4563f14bf493fe42286b1b5616

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Akademický článek

The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanoma

Autor: Barbara Montico, Giorgio Giurato, Giovanni Pecoraro, Annamaria Salvati, Alessia Covre, Francesca Colizzi, Agostino Steffan, Alessandro Weisz, Michele Maio, Luca Sigalotti, Elisabetta Fratta

Publikováno v: Molecular Oncology, Vol 16, Iss 3, Pp 565-593 (2022)

Cutaneous melanoma (CM) is a very aggressive disease, often characterized by unresponsiveness to conventional therapies and high mortality rates worldwide. The identification of the activating BRAFV600 mutations in approximately 50% of CM patients ha

Externí odkaz: https://doaj.org/article/6158288d892c4ad6a7f0325da3d7138b

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Akademický článek

Integration of miRNA:mRNA Co-Expression Revealed Crucial Mechanisms Modulated in Immunogenic Cancer Cell Death

Autor: María Julia Lamberti, Barbara Montico, Maria Ravo, Annunziata Nigro, Giorgio Giurato, Roberta Iorio, Roberta Tarallo, Alessandro Weisz, Cristiana Stellato, Agostino Steffan, Riccardo Dolcetti, Vincenzo Casolaro, Damiana Antonia Faè, Jessica Dal Col

Publikováno v: Biomedicines, Vol 10, Iss 8, p 1896 (2022)

Immunogenic cell death (ICD) in cancer represents a functionally unique therapeutic response that can induce tumor-targeting immune responses. ICD is characterized by the exposure and release of numerous damage-associated molecular patterns (DAMPs),

Externí odkaz: https://doaj.org/article/4b08764d0f134992b9af9202a6f37bf7

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Akademický článek

Enhanced Expression of CD47 Is Associated With Off-Target Resistance to Tyrosine Kinase Inhibitor Gefitinib in NSCLC

Autor: Annunziata Nigro, Luca Ricciardi, Ilaria Salvato, Francesco Sabbatino, Monica Vitale, Maria Assunta Crescenzi, Barbara Montico, Massimo Triggiani, Stefano Pepe, Cristiana Stellato, Vincenzo Casolaro, Jessica Dal Col

Publikováno v: Frontiers in Immunology, Vol 10 (2020)

Mutual interactions between cancer cells and the tumor microenvironment importantly contribute to the development of tyrosine kinase inhibitor (TKI) resistance in patients affected by EGFR-mutant NSCLC. In particular, immune recognition-associated pr

Externí odkaz: https://doaj.org/article/393bbae2a3a4486aa49dbedc9496050d

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Akademický článek

Dissecting the Multiplicity of Immune Effects of Immunosuppressive Drugs to Better Predict the Risk of de novo Malignancies in Solid Organ Transplant Patients

Autor: Michela Cangemi, Barbara Montico, Damiana A. Faè, Agostino Steffan, Riccardo Dolcetti

Publikováno v: Frontiers in Oncology, Vol 9 (2019)

De novo malignancies constitute an emerging cause of morbidity after solid organ transplant (SOT), significantly affecting the long-term survival of transplant recipients. Pharmacologic immunosuppression may functionally impair the immunosurveillance

Externí odkaz: https://doaj.org/article/840f40a28b014ae6bbc579285a5b21c0

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Abstract 4806: Spry1 as a potential new hypoxia modulator in cutaneous melanoma

Autor: Barbara Montico, Giorgio Giurato, Roberto Guerrieri, Annamaria Salvati, Francesca Colizzi, Lorena Baboci, Luca Sigalotti, Alessia Covre, Michele Maio, Agostino Steffan, Tuula A. Nyman, Alessandro Weisz, Maurizio Mongiat, Eva Andreuzzi, Elisabetta Fratta

Publikováno v: Cancer Research. 83:4806-4806

Introduction: At present, the precise role of Spry proteins in tumor progression is still debated. Our previous study showed that Spry1 knockdown (Spry1KO) in BRAFV600-mutant cutaneous melanoma (CM) promoted cell cycle arrest and apoptosis, repressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca787153c144ae03185226c54c9532bf
https://doi.org/10.1158/1538-7445.am2023-4806

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