Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Barbara McGrogan"'
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1785:96-132
The taxanes, paclitaxel and docetaxel are microtubule-stabilizing agents that function primarily by interfering with spindle microtubule dynamics causing cell cycle arrest and apoptosis. However, the mechanisms underlying their action have yet to be
Autor:
Donal J. Brennan, Elaine W. Kay, Aoife Maguire, Fiona Furlong, Barbara McGrogan, Sine Phelan, Amanda McCann, Patricia Fitzpatrick, Maria Prencipe, Anthony O'Grady, Emma Doyle
Publikováno v:
Human pathology. 45(7)
Ovarian carcinoma (OC) is the most lethal of the gynecological malignancies, often presenting at an advanced stage. Treatment is hampered by high levels of drug resistance. The taxanes are microtubule stabilizing agents, used as first-line agents in
Autor:
Catherine Duffy, Lois OConnor, Jerome Coffey, Marie Laffoy, Barbara McGrogan, Regina Codd, Triona McCarthy
Publikováno v:
Journal of Clinical Oncology. 34:e17062-e17062
e17062Background: Ovarian cancer is the main cause of gynaeocological death in Ireland (incidence 14.8/100,000). Most patients present with advanced disease. Ireland’s five-year survival, under 40%...
Autor:
Sine Phelan, Elaine W. Kay, Michael F Gallagher, John J. O'Leary, Sharon O'Toole, Amanda McCann, Paul A. McGettigan, Maria Prencipe, Patricia Fitzpatrick, Cara Martin, Donal J. Brennan, Fiona Furlong, Aloysius McGoldrick, Orla Sheils, Barbara McGrogan, Anthony O'Grady, Aoife Maguire
Publikováno v:
The Journal of Pathology
Furlong, F, Fitzpatrick, P, O'Toole, S, Phelan, S, McGrogan, B, Maguire, A, O'Grady, A, Gallagher, M, Prencipe, M, McGoldrick, A, McGettigan, P, Brennan, D, Sheils, O, Martin, C, W Kay, E, O'Leary, J & McCann, A 2012, ' Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer ', Journal of Pathology, vol. 226, no. 5, pp. 746-755 . https://doi.org/10.1002/path.3035
Furlong, F, Fitzpatrick, P, O'Toole, S, Phelan, S, McGrogan, B, Maguire, A, O'Grady, A, Gallagher, M, Prencipe, M, McGoldrick, A, McGettigan, P, Brennan, D, Sheils, O, Martin, C, W Kay, E, O'Leary, J & McCann, A 2012, ' Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer ', Journal of Pathology, vol. 226, no. 5, pp. 746-755 . https://doi.org/10.1002/path.3035
Epithelial ovarian cancer (EOC) has an innate susceptibility to become chemoresistant. Up to 30% of patients do not respond to conventional chemotherapy [paclitaxel (Taxol®) in combination with carboplatin] and, of those who have an initial response
Autor:
Antoinette S. Perry, Maria Prencipe, Donal J. Brennan, Jenny A. Watson, Anthony O'Grady, Barbara McGrogan, Patricia Fitzpatrick, Aloysius McGoldrick, Elaine W. Kay, Fiona Furlong, Sine Phelan, Mark Lawler, Amanda McCann
Publikováno v:
Cell cycle (Georgetown, Tex.). 9(14)
Aberrant expression of the MAD2 protein has been linked to chromosomal instability, malignant transformation and chemoresistance. Although reduced MAD2 expression is well recognised in human cancer cell lines, the mechanism(s) underlying its downregu