The t(14;18) translocation is absent from endothelial and follicular dendritic cells of follicular lymphoma (FL) and shows heterogeneous presence in preserved FL mantle zones

Autor: Perikles Kosmidis, Barbara Mankel, Falko Fend, Patrick Adam

Publikováno v: Diagnostic Pathology, Vol 13, Iss 1, Pp 1-7 (2018)

Abstract Background The translocation t(14;18)(q32;q21) is the genetic hallmark of follicular lymphoma (FL) and can be observed in 85–90% of cases. Whether the translocation is restricted to cells with germinal center B-cell phenotype or can be obs

Externí odkaz: https://doaj.org/article/d64fa536f3da4e939f844f81d7e4618e

Prevalence of IRF4 rearrangement in large B-cell lymphomas of the Waldeyer’s ring in adults

Autor: Sebastian Streich, Leonie Frauenfeld, Franziska Otto, Barbara Mankel, Irina Bonzheim, Falko Fend, Leticia Quintanilla-Martinez

Publikováno v: Virchows Archiv. 482:551-560

Diffuse large B-cell lymphoma (DLBCL) is the most common B-cell non-Hodgkin lymphoma (B-NHL) in adults. These lymphomas are classified according to gene expression profiling (GEP) into germinal center B-cell (GCB) and activated B-cell type (ABC). Rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a63511b0d9b49dae9b9752ff09659c74
https://doi.org/10.1007/s00428-023-03516-7

Die genetische Evolution der in situ follikulären Neoplasie zum t(14;18)-positiven aggressiven B‑Zell-Lymphom

Autor: Janine Schmidt, Birgit Federmann, Miguel A. Piris, German Ott, Julia Steinhilber, Praveen Baskaran, Antonio Vogelsberg, Ivonne A. Montes-Mojarro, Sven Nahnsen, Leticia Quintanilla-Martinez, María Rodríguez-Pinilla, Katrin Hüttl, Barbara Mankel, Irina Bonzheim, Falko Fend

Publikováno v: Der Pathologe. 42:122-128

BACKGROUND In situ follicular neoplasia (ISFN) is a t(14;18)(q32;q21)+ precursor lesion of follicular lymphoma (FL), which in turn can transform into diffuse large B‑cell lymphoma (DLBCL). For DLBCL that arise de novo, no precursor lesion is known.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d15f1a75175630f79b93cae6914d0d4
https://doi.org/10.1007/s00292-021-01011-x

Different MLL Breakpoints Influence Leukemia Characteristics of MLL-Rearranged Cells in a Human CRISPR/Cas9-Based Model

Autor: Rahel Fitzel, Sarah Brüstl, Fulya Korkmaz, Barbara Mankel, Estelle Erkner, Hildegard Keppeler, Claudia Lengerke, Dominik Schneidawind, Corina Schneidawind

Publikováno v: Blood. 140:5857-5857

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f28e1c68544ab2138db2852d610a3d1
https://doi.org/10.1182/blood-2022-169461

Follicular lymphoma t(14;18)-negative is genetically a heterogeneous disease

Autor: Leticia Quintanilla-Martinez, Inga Müller, Dominik Nann, Itziar Salaverria, Julia Salmeron-Villalobos, Falko Fend, Barbara Mankel, Blanca Gonzalez-Farre, Dolors Colomer, Sven Mattern, Elaine S. Jaffe, Stefan Dojcinov, Irina Bonzheim, Christiane Copie-Bergman, Lorenzo Leoncini, Olga Balagué, Joan Enric Ramis-Zaldivar, Caoimhe Egan, Vanessa Szablewski, Elias Campo, Carmen Lome-Maldonado, Andreas Chott, Guillem Clot, Janine Schmidt, Franziska Otto

Publikováno v: Blood Advances
Blood Advances, The American Society of Hematology, 2020, 4 (22), pp.5652-5665. ⟨10.1182/bloodadvances.2020002944⟩
Blood Adv

Fifty-five cases of t(14;18)− follicular lymphoma (FL) were genetically characterized by targeted sequencing and copy number (CN) arrays. t(14;18)− FL predominated in women (M/F 1:2); patients often presented during early clinical stages (71%), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a43c816345e6650727997dfe41da2f
https://hal.umontpellier.fr/hal-03228849