Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Barbara Majello"'
Autor:
Francesca Bibbò, Fatemeh Asadzadeh, Angelo Boccia, Carmen Sorice, Orazio Bianco, Carmen Daniela Saccà, Barbara Majello, Vittoria Donofrio, Delfina Bifano, Lucia De Martino, Lucia Quaglietta, Adriana Cristofano, Eugenio Maria Covelli, Giuseppe Cinalli, Veronica Ferrucci, Pasqualino De Antonellis, Massimo Zollo
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3917 (2024)
Medulloblastoma (MB) is a highly malignant childhood brain tumor. Group 3 MB (Gr3 MB) is considered to have the most metastatic potential, and tailored therapies for Gr3 MB are currently lacking. Gr3 MB is driven by PRUNE-1 amplification or overexpre
Externí odkaz:
https://doaj.org/article/6ba394f722c94b899e7577c0ef2e0cad
Autor:
Antonella Sarnataro, Giulia De Riso, Sergio Cocozza, Antonio Pezone, Barbara Majello, Stefano Amente, Giovanni Scala
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 5925-5934 (2022)
DNA methylation is an epigenetic modification that plays a pivotal role in major biological mechanisms, such as gene regulation, genomic imprinting, and genome stability. Different combinations of methylated cytosines for a given DNA locus generate d
Externí odkaz:
https://doaj.org/article/e64454b8a7674394b691b7f6ee98885e
Publikováno v:
Bio-Protocol, Vol 12, Iss 21 (2022)
8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) is considered to be a premutagenic DNA lesion generated by 2'-deoxyguanosine (dG) oxidation due to reactive oxygen species (ROS). In recent years, the 8-oxodG distribution in human, mouse, and yeast gen
Externí odkaz:
https://doaj.org/article/aa88a123eb7a476698aadd320e3fa967
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2031 (2023)
The guanine base in nucleic acids is, among the other bases, the most susceptible to being converted into 8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) when exposed to reactive oxygen species. In double-helix DNA, 8-oxodG can pair with adenine; hen
Externí odkaz:
https://doaj.org/article/749df458c0d842d5beddeb67eb55d584
Autor:
Susanna Ambrosio, Barbara Majello
Publikováno v:
Journal of Experimental Neuroscience, Vol 12 (2018)
The autophagy-lysosome pathway sustains cellular homeostasis and is a protective mechanism against neurodegenerative diseases. Recent findings highlight the role of the histone demethylases LSD1/LDM1A as a pivotal regulator of autophagy process, by c
Externí odkaz:
https://doaj.org/article/136f34e98db04b708802c9eeda5c5c9d
Autor:
Giuliana Napolitano, Stefano Amente, Virginia Castiglia, Barbara Gargano, Vera Ruda, Xavier Darzacq, Olivier Bensaude, Barbara Majello, Luigi Lania
Publikováno v:
PLoS ONE, Vol 8, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/7eb0f2e066fc4b06a9edab63b7654dff
Autor:
Giuliana Napolitano, Stefano Amente, Virginia Castiglia, Barbara Gargano, Vera Ruda, Xavier Darzacq, Olivier Bensaude, Barbara Majello, Luigi Lania
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11245 (2010)
BackgroundThe mechanisms by which DNA damage triggers suppression of transcription of a large number of genes are poorly understood. DNA damage rapidly induces a release of the positive transcription elongation factor b (P-TEFb) from the large inacti
Externí odkaz:
https://doaj.org/article/e2e1c362746c4da2af35c2d2e3ad1ac1
Autor:
Giovanni Scala, Francesca Gorini, Susanna Ambrosio, Andrea M Chiariello, Mario Nicodemi, Luigi Lania, Barbara Majello, Stefano Amente
8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), a major product of the DNA oxidization process, has been proposed to have an epigenetic function in gene regulation and has been associated with genome instability. NGS-based methodologies are contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabd12321287fa727d34c15d7213c08c
http://hdl.handle.net/11588/880167
http://hdl.handle.net/11588/880167
Autor:
Barbara Majello, Pier Giuseppe Pelicci, Giacomo Di Palo, Giovanni Scala, Sergio Cocozza, Stefano Amente, Francesca Gorini, Luigi Lania, Gaetano Ivan Dellino
Publikováno v:
Nucleic Acids Research
8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) is the most common marker of oxidative stress and its accumulation within the genome has been associated with major human health issues such as cancer, aging, cardiovascular and neurodegenerative diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d93bd9f083bd7e2b788c876457c0ac
https://pubmed.ncbi.nlm.nih.gov/32198884
https://pubmed.ncbi.nlm.nih.gov/32198884
Autor:
Susanna Ambrosio, Barbara Majello
Publikováno v:
Cancers
Cancers, Vol 12, Iss 1793, p 1793 (2020)
Cancers, Vol 12, Iss 1793, p 1793 (2020)
In recent years, a considerable correlation has emerged between autophagy and genome integrity. A range of mechanisms appear to be involved where autophagy participates in preventing genomic instability, as well as in DNA damage response and cell fat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a218470f3c90bf9bba67fb1f31e5c9
http://hdl.handle.net/11588/832442
http://hdl.handle.net/11588/832442