Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Barbara M. Mullock"'
Autor:
J. Paul Luzio, Barbara M. Mullock, Simon C. W. Richardson, Nicholas A. Bright, David E. James, Abigail Stewart, Sally R. Gray, Robert C. Piper, Margaret R. Lindsay, Paul R. Pryor
Publikováno v:
EMBO reports. 5:590-595
Both heterotypic and homotypic fusion events are required to deliver endocytosed macromolecules to lysosomes and remodel late endocytic organelles. A trans-SNARE complex consisting of Q-SNAREs syntaxin 7, Vti1b and syntaxin 8 and the R-SNARE VAMP8 ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9963dd000062455d1599c9d7aa334ae
https://doi.org/10.1038/sj.embor.7400150
https://doi.org/10.1038/sj.embor.7400150
Autor:
Margaret R. Lindsay, Robert C. Piper, Viviane Poupon, J. Paul Luzio, Paul R. Pryor, Barbara M. Mullock
Publikováno v:
Molecular Membrane Biology. 20:141-154
Summary Lysosomes are dynamic organelles receiving membrane traffic input from the biosynthetic, endocytic and autophagic pathways. They may be regarded as storage organelles for acid hydrolases and are capable of fusing with late endosomes to form h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::928d4261c8b1f4894d3aed8c1a9e9aeb
https://doi.org/10.1080/0968768031000089546
https://doi.org/10.1080/0968768031000089546
Autor:
Barbara M. Mullock, Margaret R. Lindsay, Paul R. Pryor, David E. James, J P Luzio, Robert C. Piper
Publikováno v:
Biochemical Society Transactions. 29:476-480
Delivery of endocytosed macromolecules to lysosomes occurs by means of direct fusion of late endosomes with lysosomes. This has been formally demonstrated in a cell-free content mixing assay using late endosomes and lysosomes from rat liver. There is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae50050a4421f478f40f95fc609d6ee
https://doi.org/10.1042/bst0290476
https://doi.org/10.1042/bst0290476
Autor:
David E. James, Nicholas A. Bright, Chez W. Smith, Doug A. Brooks, Gudrun Ihrke, Robert C. Piper, J. Paul Luzio, Emma J. Parkinson, Barbara M. Mullock, Margaret R. Lindsay, Robert G. Parton
Publikováno v:
ResearcherID
Scopus-Elsevier
Scopus-Elsevier
Protein traffic from the cell surface or the trans-Golgi network reaches the lysosome via a series of endosomal compartments. One of the last steps in the endocytic pathway is the fusion of late endosomes with lysosomes. This process has been reconst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b1c0cfff659f564a22e67dc9a034c2
https://doi.org/10.1091/mbc.11.9.3137
https://doi.org/10.1091/mbc.11.9.3137
Publikováno v:
The Journal of Cell Biology
We have investigated the requirement for Ca2+ in the fusion and content mixing of rat hepatocyte late endosomes and lysosomes in a cell-free system. Fusion to form hybrid organelles was inhibited by 1,2-bis(2-aminophenoxy) ethane-N,N,N′,N′-tetraa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2866bdd86a9dcd7a0b120dcabab5be6a
https://doi.org/10.1083/jcb.149.5.1053
https://doi.org/10.1083/jcb.149.5.1053
Publikováno v:
The Journal of Cell Biology
Using a cell-free content mixing assay containing rat liver endosomes and lysosomes in the presence of pig brain cytosol, we demonstrated that after incubation at 37°C, late endosome–lysosome hybrid organelles were formed, which could be isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfec56ac5f421e26669cb9e323d6ba3
https://doi.org/10.1083/jcb.140.3.591
https://doi.org/10.1083/jcb.140.3.591
Publikováno v:
Journal of Cell Science. 110:2027-2040
Electron microscopy was used to evaluate the function and formation of dense core lysosomes. Lysosomes were preloaded with bovine serum albumin (BSA)-gold conjugates by fluid phase endocytosis using a pulse-chase protocol. The gold particles present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67780ff21228ecc3b534f2e1b8ec97fa
https://doi.org/10.1242/jcs.110.17.2027
https://doi.org/10.1242/jcs.110.17.2027
Publikováno v:
Biochemical Journal. 308:937-946
In the present and previous studies [Mullock, Perez, Kuwana, Gray and Luzio (1994) J. Cell Biol. 126, 1173-1182], we have attempted to investigate endosome-lysosome fusion using an assay based on the dilution of the self-quenching fluorescent lipid p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d953b41077da6e068804764e8afa821
https://doi.org/10.1042/bj3080937
https://doi.org/10.1042/bj3080937
Publikováno v:
The Journal of Cell Biology
The passage of pulse doses of asialoglycoproteins through the endosomal compartments of rat liver hepatocytes was studied by subcellular fractionation and EM. The kinetics of disappearance of radiolabeled asialofetuin from light endosomes prepared on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0453b599842041a961b29b4224cb4289
https://doi.org/10.1083/jcb.126.5.1173
https://doi.org/10.1083/jcb.126.5.1173
Autor:
Barbara M. Mullock, E M Bailyes, J H Perez, Christopher P. Price, J. Paul Luzio, Margriet Van Schaik
Publikováno v:
Clinica Chimica Acta. 197:171-187
Five monoclonal antibodies which recognized three separate epitopes on the free secretory component molecule were produced using free secretory component obtained from human colostrum. Two-site immunoradiometric assays were developed to measure free
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6f0b91485cb2c11cbcb1b42dd544c1
https://doi.org/10.1016/0009-8981(91)90138-3
https://doi.org/10.1016/0009-8981(91)90138-3