Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Barbara M. Misof"'
Autor:
Roman Thaler, Farzaneh Khani, Ines Sturmlechner, Sharareh S. Dehghani, Janet M. Denbeigh, Xianhu Zhou, Oksana Pichurin, Amel Dudakovic, Sofia S. Jerez, Jian Zhong, Jeong-Heon Lee, Ramesh Natarajan, Ivo Kalajzic, Yong-hui Jiang, David R. Deyle, Eleftherios P. Paschalis, Barbara M. Misof, Tamas Ordog, Andre J. van Wijnen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
For decades vitamin C’s primary function in bone has been attributed to its involvement in collagen synthesis. Here, the authors uncover that vitamin C’s central role in bone is to globally orchestrate osteogenesis via epigenetic mechanisms.
Externí odkaz:
https://doaj.org/article/03ddd7fcf25c4309b04599c7af2fbd14
Autor:
Jakob Höppner, Katja Steff, Barbara M. Misof, Michael M. Schündeln, Matthias Hövel, Thomas Lücke, Corinna Grasemann
Publikováno v:
Bone Reports, Vol 14, Iss , Pp 100762- (2021)
Juvenile Paget disease (JPD) is an ultra-rare disease, characterized by loss of function of osteoprotegerin. Osteoprotegerin inhibits osteoclast activation via the receptor activator of nuclear factor κB (RANK) pathway. Severely affected children su
Externí odkaz:
https://doaj.org/article/89e9e52392b246f2b30c52be44c709a9
Autor:
Stéphane Blouin, Barbara M. Misof, Markus A. Hartmann, Andrea Berzlanovich, Gerlinde M. Gruber, Sonja Lueger, Phaedra Messmer, Petra Keplinger, Paul Roschger
Publikováno v:
Bone Reports, Vol 13, Iss , Pp 100675- (2020)
Externí odkaz:
https://doaj.org/article/945659bb1cad4e789b95f4dfbf077475
Autor:
Barbara M. Misof, Paul Roschger, Hua Zhou, Jeri W. Nieves, Mathias Bostrom, Felicia Cosman, Robert Lindsay, Klaus Klaushofer, David W. Dempster
Publikováno v:
Bone Reports, Vol 12, Iss , Pp 100253- (2020)
The influence of treatment with alendronate (ALN), teriparatide (TPTD) or concurrent treatment with both on the human bone matrix mineralization has not yet been fully elucidated. For this purpose we analyzed quadruple fluorochrome labelled transilia
Externí odkaz:
https://doaj.org/article/12da4b5886e64aa1ace6afbbd8769409
Autor:
Matthias Mähr, Stéphane Blouin, Martina Behanova, Barbara M. Misof, Francis H. Glorieux, Jochen Zwerina, Frank Rauch, Markus A. Hartmann, Nadja Fratzl-Zelman
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4508 (2021)
Osteocytes are terminally differentiated osteoblasts embedded within the bone matrix and key orchestrators of bone metabolism. However, they are generally not characterized by conventional bone histomorphometry because of their location and the limit
Externí odkaz:
https://doaj.org/article/5abbad0685344936b665404e859ff001
Autor:
Barbara M. Misof, Paul Roschger, Charles Chen, Maureen Pickarski, Phaedra Messmer, Klaus Klaushofer, Le T. Duong
Publikováno v:
Bone Reports, Vol 5, Iss , Pp 62-69 (2016)
Odanacatib (ODN) is a selective and reversible inhibitor of cathepsin K which is an important enzyme for the degradation of collagen I. Aim of the present work was the head-to-head comparison between the effects of ODN and alendronate (ALN) on bone m
Externí odkaz:
https://doaj.org/article/00b5e204419c42a4b586d6915559e1d2
Autor:
Barbara M. Misof, Stéphane Blouin, Jochen G. Hofstaetter, Paul Roschger, Jochen Zwerina, Reinhold G. Erben
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 7989 (2020)
Osteocytic osteolysis/perilacunar remodeling is thought to contribute to the maintenance of mineral homeostasis. Here, we utilized a reversible, adult-onset model of secondary hyperparathyroidism to study femoral bone mineralization density distribut
Externí odkaz:
https://doaj.org/article/4717c8b9c42442a7b55863bd4b89e294
Autor:
Rebecca V. Levy, Donald J. McMahon, Sanchita Agarwal, David Dempster, Hua Zhou, Barbara M. Misof, X.E. Guo, Mafo Kamanda-Kosseh, Maria Alejandra Aponte, Kimberly Reidy, Juhi Kumar, Maria Fusaro, Denver D. Brown, Michal L. Melamed, Thomas L. Nickolas
Publikováno v:
Journal of the American Society of Nephrology. 34:668-681
Autor:
Stéphane Blouin, Barbara M. Misof, Matthias Mähr, Nadja Fratzl-Zelman, Paul Roschger, Sonja Lueger, Phaedra Messmer, Petra Keplinger, Frank Rauch, Francis H. Glorieux, Andrea Berzlanovich, Gerlinde M. Gruber, Peter C. Brugger, Elizabeth Shane, Robert R. Recker, Jochen Zwerina, Markus A. Hartmann
Publikováno v:
Acta Biomaterialia. 157:275-287
Osteocytes act as bone mechanosensors, regulators of osteoblast/osteoclast activity and mineral homeostasis, however, knowledge about their functional/morphological changes throughout life is limited. We used quantitative backscattered electron imagi
Autor:
Barbara M, Misof, Stéphane, Blouin, Vicente F C, Andrade, Paul, Roschger, Victoria Z C, Borba, Markus A, Hartmann, Jochen, Zwerina, Robert R, Recker, Carolina A, Moreira
Publikováno v:
Journal of musculoskeletalneuronal interactions. 22(3)
Patients with type-2 diabetes mellitus (T2DM) have increased risk for bone fractures which points towards impaired bone quality.We measured bone mineralization density distribution (BMDD) and osteocyte lacunae section (OLS) characteristics based on q