Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Barbara M. Merrill"'
Autor:
Frederick C. Kull, Lee F. Kuyper, Jeff T. Hutchins, Julie B. Stimmel, Cary P. Moxham, Mary E. Fling, Barbara M. Merrill
Publikováno v:
Journal of Biological Chemistry. 275:30445-30450
We have engineered a cysteine residue at position 442 (EU/OU numbering) in the third constant domain (C(H)3) of the heavy chain of several IgGs with different specificities, isoforms, and variants with the intent to introduce a site for chemical conj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8525af99678f4536ba1189b39f86d7e
https://doi.org/10.1074/jbc.m001672200
https://doi.org/10.1074/jbc.m001672200
Publikováno v:
Analytical Biochemistry. 247:102-110
CAMPATH-1H is a recombinant humanized murine monoclonal immunoglobulin (IgG1) which recognizes the CDw52 antigen of human lymphocytes, and has been the subject of clinical trials for the treatment of non-Hodgkin's lymphoma and rheumatoid arthritis. P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fd036cbee3f2db069b958f0b69e38f
https://doi.org/10.1006/abio.1997.2036
https://doi.org/10.1006/abio.1997.2036
Publikováno v:
Journal of Biological Chemistry. 270:15827-15831
Valaciclovir is an oral prodrug of the antiherpetic agent acyclovir. An enzyme that hydrolyzes valaciclovir to acyclovir, valaciclovir hydrolase (VACVase), was purified from rat liver and characterized. VACVase was a basic (pI 9.4) protein associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ac0398d78174a92d1b669437dc0978
https://doi.org/10.1074/jbc.270.26.15827
https://doi.org/10.1074/jbc.270.26.15827
Publikováno v:
Journal of Biological Chemistry. 268:10054-10059
CaM kinase-Gr is a Ca2+/calmodulin-dependent protein kinase that is enriched in brain and thymus. The enzyme was isolated from rat cerebellum, which contained alpha (M(r) 65,000) and beta (M(r) 67,000) polypeptides, and rat forebrain, which contained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3a571dd813b5690ba61d2e01c3ebc83
https://doi.org/10.1016/s0021-9258(18)82171-8
https://doi.org/10.1016/s0021-9258(18)82171-8
Publikováno v:
Journal of Biological Chemistry. 267:5236-5242
Uracil analogues with appropriate substituents at the 5-position inactivated dihydropyrimidine dehydrogenase (DHPDHase). The efficiency of these inactivators was highly dependent on the size of the 5-substituent. For example, 5-ethynyluracil inactiva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4069a639ce702e6281b9c7bbdd43d288
https://doi.org/10.1016/s0021-9258(18)42757-3
https://doi.org/10.1016/s0021-9258(18)42757-3
Publikováno v:
Journal of Biological Chemistry. 266:19988-19994
5-Iodouracil was a substrate for bovine liver dihydropyrimidine dehydrogenase (DHPDHase) and was a potent inactivator of the enzyme. NADPH increased the rate of inactivation and thymine protected against inactivation. These findings suggest that 5-io
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ad117d43c98cb44b2ff3ca1f2cfb7c5
https://doi.org/10.1016/s0021-9258(18)54881-x
https://doi.org/10.1016/s0021-9258(18)54881-x
Autor:
Ramesh Rajpurohit, Kenneth R. Williams, Vladimir V. Papov, Jennifer M. Schneiders, Samuel H. Wilson, Woon Ki Paik, Wlodzimierz Szer, Kathryn L. Stone, Sangduk Kim, Amalendra Kumar, Barbara M. Merrill
Publikováno v:
Biochemistry. 36(17)
Three sites of N(G),N(G)-arginine methylation have been located at residues 205, 217, and 224 in the glycine-rich, COOH-terminal one-third of the HeLa A1 heterogeneous ribonucleoprotein. Together with the previously determined dimethylated arginine a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38214603f0953463cf455626613bc0c9
https://pubmed.ncbi.nlm.nih.gov/9136880
https://pubmed.ncbi.nlm.nih.gov/9136880
Autor:
Arie Admon, Kathryn L. Stone, William J. Henzel, Barbara M. Merrill, Karen De Jongh, Joseph Fernandez, Greg Grant, William S. Lane
Publisher Summary The ability of most core laboratories to interpret data correctly from a homogenous and relatively high-level sample that has no amino acids that are difficult to identify, is of a finite length, and has clear PTH chromatograms is e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b18b5ba25ea16835ed3abcc796973d5
https://doi.org/10.1016/s1080-8914(97)80010-5
https://doi.org/10.1016/s1080-8914(97)80010-5
Autor:
John Rush, Jay E. Gambee, Kathryn L. Stone, Karen S. De Jongh, Gregory A. Grant, Barbara M. Merrill, Joseph Fernandez
Publisher Summary This chapter summarizes the sequencing results for the current test sample, ABRF-95SEQ that represents the eighth in a series of unknown samples that have been distributed to Amino Acid Analysis Research Committee of the Association
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b287a50bc0e23438655776b5ae698392
https://doi.org/10.1016/s1080-8914(96)80039-1
https://doi.org/10.1016/s1080-8914(96)80039-1
Publikováno v:
The Journal of biological chemistry. 270(26)
2'-Fluoro-2'-deoxyarabinonucleosides are time-dependent inhibitors of nucleoside 2-deoxyribosyltransferase. 2,6-Diamino-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-9H-purine (dFDAP) inhibited the enzyme by formation of a primary complex (Kd = 140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1476eedf3e1960e261b0b2f02b3d8e9e
https://pubmed.ncbi.nlm.nih.gov/7797550
https://pubmed.ncbi.nlm.nih.gov/7797550