Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Barbara M Bröker"'
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192197 (2018)
Sepsis is frequently complicated by a state of profound immunosuppression, in its extreme form known as immunoparalysis. We have studied the role of the adaptive immune system in the murine acute peritonitis model. To read out adaptive immunosuppress
Externí odkaz:
https://doaj.org/article/98f2ffda4dad4792a88861662477cf47
Autor:
Franziska Scherr, Murthy N. Darisipudi, Friedemann R. Börner, Sophie Austermeier, Franziska Hoffmann, Martin Eberhardt, Goran Abdurrahman, Christopher Saade, Ferdinand von Eggeling, Lydia Kasper, Silva Holtfreter, Barbara M. Bröker, Michael Kiehntopf
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe serine protease like (Spl) proteases of Staphylococcus aureus are a family of six proteases whose function and impact on virulence are poorly understood. Here we propose alpha-1-antitrypsin (AAT), an important immunomodulatory serine pr
Externí odkaz:
https://doaj.org/article/43ca3b59a4ca4f3cac8c82175b6f3890
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129182 (2015)
Cladribine is a cytotoxic drug which ameliorates the clinical course of relapsing-remitting multiple sclerosis. In addition to cytotoxicity, the mode of action may include immunomodulatory mechanisms. This in vitro study was designed to investigate c
Externí odkaz:
https://doaj.org/article/ce328e5412184605a4b22e4e1f8c4c93
Autor:
Floriane C M Braun, Jens van den Brandt, Sören Thomas, Sandra Lange, Juliane Schrank, Claudia Gand, Grzegorz K Przybylski, Katrin Schmoeckel, Barbara M Bröker, Christian A Schmidt, Piotr Grabarczyk
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0135444 (2015)
A20 is an ubiquitin-editing enzyme that ensures the transient nature of inflammatory signaling pathways induced by cytokines like TNF-α and IL-1 or pathogens via Toll-like receptor (TLR) pathways. It has been identified as a negative regulator of de
Externí odkaz:
https://doaj.org/article/7a427a310d524b2f9394b2e9fea93d54
Autor:
Daniela Kuthning, Dina Raafat, Silva Holtfreter, Jana Gramenz, Nico Wittmann, Barbara M. Bröker, Almut Meyer-Bahlburg
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Monitoring the seroprevalence of SARS-CoV-2 in children and adolescents can provide valuable information for effective SARS-CoV-2 surveillance, and thus guide vaccination strategies. In this study, we quantified antibodies against the spike S1 domain
Externí odkaz:
https://doaj.org/article/6cd9eb01977b4e4f88e8364cac868002
Autor:
Goran Abdurrahman, Rebecca Pospich, Leif Steil, Manuela Gesell Salazar, Juan José Izquierdo González, Nicole Normann, Daniel Mrochen, Christian Scharf, Uwe Völker, Thomas Werfel, Barbara M. Bröker, Lennart M. Roesner, Lidia Gómez-Gascón
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundAtopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease with skin barrier defects and a misdirected type 2 immune response against harmless antigens. The skin microbiome in AD is characterized by a reduction in microbial di
Externí odkaz:
https://doaj.org/article/2ffbfd599c934f85a83ca84c7246d9c5
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81752 (2013)
Patients with sepsis are often immune suppressed, and experimental mouse models of sepsis also display this feature. However, acute sepsis in mice is also characterized by a generalized B cell activation and plasma cell differentiation, resulting in
Externí odkaz:
https://doaj.org/article/6043c52fd2aa4efa96aa58fcc43d6b2e
Autor:
Silva Holtfreter, Fiona J Radcliff, Dorothee Grumann, Hannah Read, Sarah Johnson, Stefan Monecke, Stephen Ritchie, Fiona Clow, Christiane Goerke, Barbara M Bröker, John D Fraser, Siouxsie Wiles
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e71142 (2013)
More effective antibiotics and a protective vaccine are desperately needed to combat the 'superbug' Staphylococcus aureus. While in vivo pathogenicity studies routinely involve infection of mice with human S. aureus isolates, recent genetic studies h
Externí odkaz:
https://doaj.org/article/2177ecd54e1043b6aec02362dcae7e77
Autor:
Franziska Kühlhorn, Matthias Rath, Katrin Schmoeckel, Katharina Cziupka, Huu Hung Nguyen, Petra Hildebrandt, Thomas Hünig, Tim Sparwasser, Jochen Huehn, Christian Pötschke, Barbara M Bröker
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e65109 (2013)
The role of regulatory T cells (Tregs) in bacterial sepsis remains controversial because antibody-mediated depletion experiments gave conflicting results. We employed DEREG mice (DEpletion of REGulatory T cells) and a caecal ligation and puncture mod
Externí odkaz:
https://doaj.org/article/88f54fab229b416daa6f6610c46ad393
Autor:
Antje Vogelgesang, Verena E L May, Uwe Grunwald, Maren Bakkeboe, Soenke Langner, Henry Wallaschofski, Christof Kessler, Barbara M Bröker, Alexander Dressel
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8718 (2010)
Stroke is a major cause of disability and leading cause of death in the northern hemisphere. Only recently it became evident that cerebral ischemia not only leads to brain tissue damage and subsequent local inflammation but also to a dramatic loss of
Externí odkaz:
https://doaj.org/article/5d124dfd2fb243aca4f482b56590d19f