Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Barbara M, Grüner"'
Autor:
Vivien Ullrich, Sarah Ertmer, Anna Baginska, Madeleine Dorsch, Hanah H. Gull, Igor Cima, Pia Berger, Celia Dobersalske, Sarah Langer, Loona Meyer, Philip Dujardin, Sied Kebir, Martin Glas, Tobias Blau, Kathy Keyvani, Laurèl Rauschenbach, Ulrich Sure, Alexander Roesch, Barbara M. Grüner, Björn Scheffler
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108596- (2024)
Summary: Adaptive plasticity to the standard chemotherapeutic temozolomide (TMZ) leads to glioblastoma progression. Here, we examine early stages of this process in patient-derived cellular models, exposing the human lysine-specific demethylase 5B (K
Externí odkaz:
https://doaj.org/article/de837c3bce3d4267b86e9e795b2ebef0
Autor:
Shin-Heng Chiou, Madeleine Dorsch, Eva Kusch, Santiago Naranjo, Margaret M. Kozak, Albert C. Koong, Monte M. Winslow, Barbara M. Grüner
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Expression of the chromatin-associated protein HMGA2 correlates with progression, metastasis and therapy resistance in pancreatic ductal adenocarcinoma (PDAC). Hmga2 has also been identified as a marker of a transient subpopulation of PDAC c
Externí odkaz:
https://doaj.org/article/b72834b1a36a49d0bfd2fb6d72fac298
Autor:
Dian Yang, Fangfei Qu, Hongchen Cai, Chen-Hua Chuang, Jing Shan Lim, Nadine Jahchan, Barbara M Grüner, Christin S Kuo, Christina Kong, Madeleine J Oudin, Monte M Winslow, Julien Sage
Publikováno v:
eLife, Vol 8 (2019)
Metastasis is the main cause of death in cancer patients but remains a poorly understood process. Small cell lung cancer (SCLC) is one of the most lethal and most metastatic cancer types. SCLC cells normally express neuroendocrine and neuronal gene p
Externí odkaz:
https://doaj.org/article/fda050c064b3492b90714973d6d4255b
Autor:
Monte M. Winslow, Amato J. Giaccia, Albert C. Koong, Philippe Mourrain, Grace E. Kim, Edward E. Graves, Laura Castellini, Margaret Kozak, Pauline Chu, Dedeepya Vaka, Rosanna K. Ma, Arwa S. Kathiria, Barbara M. Grüner, Dian Yang, Gordon X. Wang, Viviana I. Risca, Shin-Heng Chiou
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc818e80ec13b4966326cd3229b9a23
https://doi.org/10.1158/2159-8290.22531568
https://doi.org/10.1158/2159-8290.22531568
Autor:
Jens T. Siveke, Axel Walch, Roland M. Schmid, Irene Esposito, Michaela Aichler, Rickmer Braren, Katja Steiger, Evdokia Kalideris, Alexander Herner, Nicole Teichmann, Benjamin Balluff, Na Sun, Annette Feuchtinger, Isabel Winkelmann, Barbara M. Grüner
Supplementary Figure S2. This supplementary figure depicts the non-correlation of average erlotinib peak intensities with survival or tumor grading or overall morphological feature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616c0cbe76f807795302c8b7b5bc112f
https://doi.org/10.1158/1535-7163.22508320.v1
https://doi.org/10.1158/1535-7163.22508320.v1
Autor:
Monte M. Winslow, Amato J. Giaccia, Albert C. Koong, Philippe Mourrain, Grace E. Kim, Edward E. Graves, Laura Castellini, Margaret Kozak, Pauline Chu, Dedeepya Vaka, Rosanna K. Ma, Arwa S. Kathiria, Barbara M. Grüner, Dian Yang, Gordon X. Wang, Viviana I. Risca, Shin-Heng Chiou
Supplementary Table S1, Gene sets that are enriched in Hmga2/GFP-positive and -negative PDAC cells; Supplementary Table S2, A stringent list of Blimp1-dependent genes that are either induced or repressed under hypoxia; Supplementary Table S3, GO term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8b258f8610a53bd4b0981e6efe92ce
https://doi.org/10.1158/2159-8290.22531565
https://doi.org/10.1158/2159-8290.22531565
Autor:
Monte M. Winslow, Amato J. Giaccia, Albert C. Koong, Philippe Mourrain, Grace E. Kim, Edward E. Graves, Laura Castellini, Margaret Kozak, Pauline Chu, Dedeepya Vaka, Rosanna K. Ma, Arwa S. Kathiria, Barbara M. Grüner, Dian Yang, Gordon X. Wang, Viviana I. Risca, Shin-Heng Chiou
Supplementary Figure S1. Isolation of the Hmga2-GFPpos PDAC sub-population from the KPCcolors mice and GFPpos PDAC cells are a highly metastatic state;Supplementary Figure S2. Highly metastatic PDAC cells have a gene signature that is not enriched fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbce71d8dcf5dd804dbc2c49987c5100
https://doi.org/10.1158/2159-8290.22531571.v1
https://doi.org/10.1158/2159-8290.22531571.v1
Autor:
Jens T. Siveke, Axel Walch, Roland M. Schmid, Irene Esposito, Michaela Aichler, Rickmer Braren, Katja Steiger, Evdokia Kalideris, Alexander Herner, Nicole Teichmann, Benjamin Balluff, Na Sun, Annette Feuchtinger, Isabel Winkelmann, Barbara M. Grüner
Supplemental material and methods file
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd2f9e12da53815e04fd372c368c5b1
https://doi.org/10.1158/1535-7163.22508317.v1
https://doi.org/10.1158/1535-7163.22508317.v1
Autor:
Björn Scheffler, Martin Glas, Matthias Simon, Oliver Brüstle, Ulrich Sure, Michael Weller, Guido Reifenberger, Jörg Felsberg, Torsten Pietsch, Frank K.H. van Landeghem, Kathy Keyvani, Tobias Blau, Christel Herold-Mende, Jens T. Siveke, Alexander Roesch, Barbara M. Grüner, Marc Remke, Verena Jendrossek, Johann Matschke, Shruthi Prasad, Igor Cima, Holger Fröhlich, Ashar Ahmad, Timo Wilhelm-Buchstab, Anja Wieland, Franziska K. Lorbeer, Andreas Till, Daniel Trageser, Laurèl Rauschenbach, Sarah Langer, Celia Dobersalske, Pia Berger, Vivien Ullrich, Sied Kebir
Extended Data relating to Main Figure 3/AKT-driven progression of ALDH1A1+ cells in glioblastoma. A, Flow cytometry histograms showing ALDH1A1 expression in the paired treatment-naive vs. clinical relapse patient samples quantified in main Fig. 3A. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015c1ca113ad006a8dc6af892729aae8
https://doi.org/10.1158/1078-0432.22488669.v1
https://doi.org/10.1158/1078-0432.22488669.v1
Autor:
Björn Scheffler, Martin Glas, Matthias Simon, Oliver Brüstle, Ulrich Sure, Michael Weller, Guido Reifenberger, Jörg Felsberg, Torsten Pietsch, Frank K.H. van Landeghem, Kathy Keyvani, Tobias Blau, Christel Herold-Mende, Jens T. Siveke, Alexander Roesch, Barbara M. Grüner, Marc Remke, Verena Jendrossek, Johann Matschke, Shruthi Prasad, Igor Cima, Holger Fröhlich, Ashar Ahmad, Timo Wilhelm-Buchstab, Anja Wieland, Franziska K. Lorbeer, Andreas Till, Daniel Trageser, Laurèl Rauschenbach, Sarah Langer, Celia Dobersalske, Pia Berger, Vivien Ullrich, Sied Kebir
Purpose:Therapy resistance and fatal disease progression in glioblastoma are thought to result from the dynamics of intra-tumor heterogeneity. This study aimed at identifying and molecularly targeting tumor cells that can survive, adapt, and subclona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9b80ef2c400c9da401843e9c7ab77e
https://doi.org/10.1158/1078-0432.c.6532785.v1
https://doi.org/10.1158/1078-0432.c.6532785.v1