Výsledky vyhledávání - "Barbara Loesch"

Abstract 4057: T cells co-expressing a highly potent NY-ESO-1-specific TCR and a chimeric PD1-41BB co-stimulatory switch receptor show a favorable polyfunctional profile for the treatment of solid tumors

Autor: Andrea Coluccio, Stefanie Tippmer, Petra Prinz, Maja Buerdek, Kathrin Mutze, Barbara Loesch, Kathrin Davari, Giulia Longinotti, Dolores J. Schendel

Publikováno v: Cancer Research. 83:4057-4057

T cell receptor (TCR)-based immunotherapies have shown great potential for the safe and efficacious treatment of patients suffering from various solid malignancies. However, novel strategies are needed to overcome the immunosuppressive tumor microenv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfff739fbccc53bb0aad582e1f20ae0c
https://doi.org/10.1158/1538-7445.am2023-4057

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189 Targeting a novel shared tumor-specific antigen with T cell receptor transduced T cells for the treatment of ovarian cancer

Autor: Slavoljub Milosevic, Krystel Vincent, Daniel Sommermeyer, Dolores J. Schendel, Alexander Schmidt, Barbara Loesch, Adriana Turqueti Neves, Alexandra Kuhlenkamp, Andreas Acs, Tiziana Franceschetti, Justyna Ogonek, Claude Perreault

Publikováno v: Journal for ImmunoTherapy of Cancer. 9:A201-A201

BackgroundTransgenic T cell receptor (TCR)-based T cell therapies are a powerful treatment for cancer. However, one of the greatest remaining challenges is the successful identification of tumor-specific antigens (TSAs) that are shared between patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::363f4f9cbb448c797e92f4a388d2e9f4
https://doi.org/10.1136/jitc-2021-sitc2021.189

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Identification of Novel Crk-associated Substrate (p130Cas) Variants with Functionally Distinct Focal Adhesion Kinase Binding Activities

Autor: Barbara Loesch, Joerg Kumbrink, Barbara Laumbacher, Kathrin H. Kirsch, Shefali Soni

Publikováno v: Journal of Biological Chemistry. 290:12247-12255

Elevated levels of p130Cas (Crk-associated substrate)/BCAR1 (breast cancer antiestrogen resistance 1 gene) are associated with aggressiveness of breast tumors. Following phosphorylation of its substrate domain, p130Cas promotes the integration of pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c4680db512a0a93f78557b67fa62e3
https://doi.org/10.1074/jbc.m115.649947

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