Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex

Autor: Nereo Kalebic, Carlotta Gilardi, Mareike Albert, Takashi Namba, Katherine R Long, Milos Kostic, Barbara Langen, Wieland B Huttner

Publikováno v: eLife, Vol 7 (2018)

The evolutionary increase in size and complexity of the primate neocortex is thought to underlie the higher cognitive abilities of humans. ARHGAP11B is a human-specific gene that, based on its expression pattern in fetal human neocortex and progenito

Externí odkaz: https://doaj.org/article/dcc43a7dd3f248f78dee46066d103473

Author response: Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex

Autor: Katherine R. Long, Wieland B. Huttner, Barbara Langen, Carlotta Gilardi, Mareike Albert, Nereo Kalebic, Takashi Namba, Milos Kostic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2538ea2c704eb261c5530b87ecab0522
https://doi.org/10.7554/elife.41241.022

Extracellular Matrix Components HAPLN1, Lumican, and Collagen I Cause Hyaluronic Acid-Dependent Folding of the Developing Human Neocortex

Autor: Katherine R. Long, Wieland B. Huttner, Ben Newland, Anna Kolterer, Pauline Wimberger, Barbara Langen, Marta Florio, Nereo Kalebic

Publikováno v: Long, K R, Newland, B, Florio, M, Kalebic, N, Langen, B, Kolterer, A, Wimberger, P & Huttner, W B 2018, ' Extracellular Matrix Components HAPLN1, Lumican, and Collagen I Cause Hyaluronic Acid-Dependent Folding of the Developing Human Neocortex ', Neuron, vol. 99, no. 4, pp. 702-719.e7 . https://doi.org/10.1016/j.neuron.2018.07.013

Neocortical expansion, thought to underlie the cognitive traits unique to humans, is accompanied by cortical folding. This folding starts around gestational week (GW) 20, but what causes it remains largely unknown. Extracellular matrix (ECM) has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7caa528ebfc3038e65dde66ffa342fa9
https://kclpure.kcl.ac.uk/en/publications/db673605-d426-406d-b994-3976cbb34de7

Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology

Autor: Carlotta Gilardi, Marta Florio, Barbara K. Stepien, Hiroshi Kawasaki, Katherine R. Long, Wieland B. Huttner, Takashi Namba, Barbara Langen, Pauline Wimberger, Benoit Lombardot, Manfred W. Kilimann, Nereo Kalebic, Michaela Wilsch-Bräuninger, Anna Shevchenko

Publikováno v: Kalebic, N, Gilardi, C, Stepien, B, Wilsch-Bräuninger, M, Long, K R, Namba, T, Florio, M, Langen, B, Lombardot, B, Shevchenko, A, Kilimann, M W, Kawasaki, H, Wimberger, P & Huttner, W B 2019, ' Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology ', Cell Stem Cell, vol. 24, no. 4, pp. 535-550.e9 . https://doi.org/10.1016/j.stem.2019.02.017

The evolutionary expansion of the mammalian neocortex (Ncx) is thought to be linked to increased proliferative capacity of basal progenitors (BPs) and their neurogenic capacity. Here, by quantifying BP morphology in the developing Ncx of mouse, ferre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d89e5c268392e312e30af71d367f75
https://doi.org/10.1016/j.stem.2019.02.017

Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors

Autor: Albert J. Robichaud, Norbert Hoefgen, Karen L. Marquis, Steven M. Grauer, Hans Stange, Radka Graf, Ute Egerland, Thorsten Hage, Christian Grunwald, Julie A. Brennan, Michael S. Malamas, Boyd L. Harrison, Menelas N. Pangalos, Kevin Parris, Thomas Kronbach, Yike Ni, Kristi Fan, Rudolf Schindler, Rachel Navarra, Hans-Joachim Lankau, Nicholas J. Brandon, James Joseph Erdei, Barbara Langen

Publikováno v: Journal of Medicinal Chemistry. 54:7621-7638

The identification of highly potent and orally active phenylpyrazines for the inhibition of PDE10A is reported. The new analogues exhibit subnanomolar potency for PDE10A, demonstrate high selectivity against all other members of the PDE family, and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3f324255336d82f4fabd618b4bcef3
https://doi.org/10.1021/jm2009138