Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Barbara L. Storer"'
Publikováno v:
Thrombosis Research. 57:967-974
The effects of newly discovered vasoconstrictor peptide endothelin was studied on human, rabbit and canine platelet function. Endothelin (0.01 nM-1 microM) did not promote platelet aggregation. In human platelets, endothelin (0.1 microM) did not sign
Autor:
Giora Z. Feuerstein, Barbara L. Storer, Richard E. Valocik, Paul F. Koster, Michael N. Blackburn, John R. Toomey
Publikováno v:
Thrombosis research. 100(1)
A humanized inhibitory anti-factor IX(a) antibody (SB 249417) has been compared to enoxaparin (Lovenox) in a rat model of arterial thrombosis. Pretreatment of rats with either SB 249417 (3.0 mg/kg, i. v.) or enoxaparin (30.0 mg/kg, i.v. or s.c.) resu
Publikováno v:
British Journal of Pharmacology. 104:987-989
1. Six weeks following partial nephrectomy in rats, significant increases in serum urea nitrogen and serum creatinine concentration and a significant decrease in creatinine clearance were observed. 2. Measurement of systolic blood pressure by tail pl
Autor:
David P. Brooks, Madelyn M. Caltabiano, Ponnal Nambi, Lisa C. Contino, Eliot H. Ohlstein, Mark Pullen, Barbara L. Storer
Publikováno v:
European Journal of Pharmacology. 194:115-117
The aim of the present study was to determine the effect of a calcium channel blocker on renal function, urinary endothelin excretion and endothelin receptor number in rats. Administration of cyclosporine resulted in a significant impairment of renal
Autor:
Luengo Juan Ignacio, John D. Elliott, Jia-Ning Xiang, Stephanie Guiney, Eliot H. Ohlstein, Robert N. Willette, Barbara L. Storer, Charles F. Sauermelch
Publikováno v:
Journal of cardiovascular pharmacology. 31
Some endothelin (ET) receptor antagonists have been reported to elevate plasma immunoreactive endothelin-1 (irET-1). However, there is no information regarding the effects of ET receptor antagonists on cerebrospinal fluid (CSF) levels. To better unde
Publikováno v:
Journal of molecular and cellular cardiology. 30(1)
Carvedilol, a multiple action neurohumoral antagonist, has been reported recently to significantly reduce mortality in congestive heart failure (CHF) patients. In addition to being a beta-adrenoceptor antagonist, one of the unique aspects of the biol
Autor:
A. Nichols, J. Samanen, Linda J. Kopaciewicz, Barbara L. Storer, Raul R. Calvo, Janice A. Vasko, Fadia E. Ali, Richard E. Valocik, Todd Romoff
Publikováno v:
Thrombosis research. 75(2)
The properties of SK&F 106760 [N alpha-acetyl-cyclo(S,S)-cysteinyl-N alpha-methyl-arginyl-glycyl-aspartyl-penicillamine-amide] as a GPIIb/IIIa antagonist have been studied in vitro and compared with those of the parent molecule, Ac-RGDS-NH2. Ac-RGDS-
Autor:
Eliot H. Ohlstein, Barbara L. Storer, Ponnal Nambi, Mark Pullen, M.J. Slivjak, Edward F. Smith
Publikováno v:
Pharmacology. 48(3)
The purpose of these studies was to examine the changes in renal endothelin (ET) receptor, renal function and plasma ET (ET-1) concentration in male Sprague-Dawley rats injected with nonlethal doses of Escherichia coli endotoxin (LPS). Prior to the i
Autor:
Fadia E. Ali, A. Nichols, Raul R. Calvo, J. Vasko, Barbara L. Storer, D. Bennett, D. Berry, E. Sorenson, Jeffrey M. Stadel, M. Strohsacker, David Powers, J. Samanen, T T Romoff
Publikováno v:
Journal of medicinal chemistry. 34(10)
The development of potent antithrombotic agents from the fibrinogen platelet receptor binding sequences Fg-alpha 572-575 -Arg-Gly-Asp-Ser- and Fg-gamma 400-411 -HHLGGAKQAGDV, believed to be a cryptic RGD-type sequence, is described. The tetrapeptide
Autor:
Xin L. Ma, Padma K. Narayanan, Eliot H. Ohlstein, Tian-Li Yue, Lynne M. Vickery-Clark, Kent A. Gossett, Robert N. Willette, Barbara L. Storer, Calvert Louden, Xiang Li, Jun Chen, Juan-Li Gu
Publikováno v:
Circulation. 102:III-281
Background—Idoxifene (ID) is a tissue-selective estrogen receptor modulator (SERM). The pharmacological profile of ID in animal studies suggests that it behaves like an estrogen receptor (ER) agonist in bone and lipid metabolism while having neglig