Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Barbara L. Pope"'
Publikováno v:
European Journal of Immunology. 26:120-129
Inflammation is characterized by the migration of polymorphonuclear leukocytes from the vasculature into the tissue causing profound injury. Adhesion and migration of neutrophils across the vascular bed are governed by a series of complex events incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b149317b1f790ab2176dd0cdc285a5db
https://doi.org/10.1002/eji.1830260119
https://doi.org/10.1002/eji.1830260119
Publikováno v:
Cancer Immunology Immunotherapy. 38:83-91
We have shown previously that loxoribine exhibits adjuvant activity for B cells, activates natural killer (NK) cells, and enhances the activation of lymphokine-activated killer cells by interleukin-2 (IL-2). In this study, we examined loxoribine for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b3fb81eb469763a406cf5d0bc4a883
https://doi.org/10.1007/bf01526202
https://doi.org/10.1007/bf01526202
Autor:
Marianne S. Rampulla, Barbara L. Pope, D C Argentieri, Reitz Allen B, Stanley C. Bell, Dieter H. Klaubert, Robert Chen, Mary R. Schott, L. E. Burr, Michael G. Goodman, Bruce E. Maryanoff, J H Goodman, J. Come
Publikováno v:
ChemInform. 26
7-Allyl-8-oxoguanosine (loxoribine, 5) was selected from a series of guanosine derivatives for further evaluation as an immunostimulant. Numerous related analogs were also synthesized and evaluated: 2′,3′-ketals of 5 are particularly interesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::818604bd5976e742bb4a1712112cc25b
https://doi.org/10.1002/chin.199502193
https://doi.org/10.1002/chin.199502193
Publikováno v:
Immunobiology. 180:243-260
We have shown previously that the natural killer (NK) cell activity of DBA/2J mice bearing M-1 fibrosarcomas is consistently depressed at the later stages of tumor growth. The apparent mechanisms of inhibition are suppressor cell activation and prost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8690685d408322ef04844baa25d34c54
https://doi.org/10.1016/s0171-2985(11)80332-3
https://doi.org/10.1016/s0171-2985(11)80332-3
Autor:
Lubing Zhou, J. P. Macintyre, G. R. Taylor, Barbara L. Pope, E. Kimball, S. Lee, Michael G. Goodman
Publikováno v:
Cellular immunology. 162(2)
C8- and N7, C8-substituted guanine ribonucleosides comprise a class of molecules with potent immunostimulatory activity for a variety of humoral and cellular immune responses. Although it has been suggested that the immunostimulatory activity may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8defb71390a26f4a1f2a22217d73462
https://pubmed.ncbi.nlm.nih.gov/7743561
https://pubmed.ncbi.nlm.nih.gov/7743561
Publikováno v:
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy. 17(2)
Guanine ribonucleosides with single substitutions at the C8 position (monosubstituted) or with dual substitutions at the C8 and N7 positions (disubstituted) up-regulate a spectrum of immunologic responses, including cytolytic responses to tumor cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7d39adadf78c60f10bdb4856f3ded8
https://pubmed.ncbi.nlm.nih.gov/7647961
https://pubmed.ncbi.nlm.nih.gov/7647961
Publikováno v:
Cellular immunology. 159(2)
7-Allyl-8-oxoguanosine (loxoribine) is a di-substituted guanine ribonucleoside which has been shown previously to enhance murine NK activity, B lymphocyte proliferation, and antibody synthesis. In this study we examined the relationship among enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412fcde42e7a1375e4819862d3be9900
https://pubmed.ncbi.nlm.nih.gov/7994754
https://pubmed.ncbi.nlm.nih.gov/7994754
Autor:
Erika Chourmouzis, Robert J. Capetola, JoAnn Sigindere, Barbara L. Pope, J.Philip MacIntyre, Catherine Y. Lau
Publikováno v:
Cellular immunology. 147(2)
Guanine ribonucleosides which have been substituted at the N7 and/or C8 positions have been shown previously to activate natural killer (NK) cells and to act as sparing agents for interleukin-2 (IL-2) in the in vitro generation of lymphokine activate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91edc3a3c106b64b1fa088a675b1d8f
https://pubmed.ncbi.nlm.nih.gov/8453674
https://pubmed.ncbi.nlm.nih.gov/8453674
Publikováno v:
International journal of immunopharmacology. 14(8)
7-Allyl-8-oxoguanosine (loxoribine) is a novel immunostimulatory compound which has been shown previously to enhance the antibody synthesis of antigen-stimulated B-lymphocytes. In this report, loxoribine was tested for the ability to activate murine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be43699d70ccdfdb84427051ac618f6
https://pubmed.ncbi.nlm.nih.gov/1464469
https://pubmed.ncbi.nlm.nih.gov/1464469
Autor:
Barbara L. Pope, J.Philip MacIntyre
Publikováno v:
International journal of immunopharmacology. 13(2-3)
The cloned interleukin-3 dependent cell line, M1-A5 was studied to determine whether protein kinase C, calcium mobilization, and 5-lipoxygenase activity were involved in the signal transduction pathways required for the production of TNF. TNF release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75461a3d011188f11295a9ad0bb555a
https://pubmed.ncbi.nlm.nih.gov/1906437
https://pubmed.ncbi.nlm.nih.gov/1906437