Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Barbara Kutryb–Zajac"'
Autor:
Paulina Mierzejewska, Noemi Di Marzo, Magdalena A. Zabielska-Kaczorowska, Iga Walczak, Ewa M. Slominska, Marialuisa Lavitrano, Roberto Giovannoni, Barbara Kutryb-Zajac, Ryszard T. Smolenski
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1409 (2023)
The vascular endothelium is key target for immune and thrombotic responses that has to be controlled in successful xenotransplantation. Several genes were identified that, if induced or overexpressed, help to regulate the inflammatory response and pr
Externí odkaz:
https://doaj.org/article/1aac718b525641dba818c8e7147fa536
Autor:
Barbara Kutryb-Zajac, Ada Kawecka, Fionä Caratis, Krzysztof Urbanowicz, Alicja Braczko, Tomomi Furihata, Bartosz Karaszewski, Ryszard T. Smolenski, Aleksandra Rutkowska
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
BackgroundAdenosine deaminase (ADA) via two isoenzymes, ADA1 and ADA2, regulates intra- and extracellular adenosine concentrations by converting it to inosine. In the central nervous system (CNS), adenosine modulates the processes of neuroinflammatio
Externí odkaz:
https://doaj.org/article/a7c4d3fc01674f688619ce6a937392de
Autor:
Barbara Kutryb-Zajac, Ada Kawecka, Alicja Braczko, Marika Franczak, Ewa M. Slominska, Roberto Giovannoni, Ryszard T. Smolenski
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1540 (2022)
Chronic hypoxia drives vascular dysfunction by various mechanisms, including changes in mitochondrial respiration. Although endothelial cells (ECs) rely predominantly on glycolysis, hypoxia is known to alter oxidative phosphorylation, promote oxidati
Externí odkaz:
https://doaj.org/article/f1ce3c754dac4508a64e0ab3cf00dab9
Autor:
Patrycja Jablonska, Paulina Mierzejewska, Marta Tomczyk, Patrycja Koszalka, Marika Franczak, Ada Kawecka, Barbara Kutryb-Zajac, Alicja Braczko, Ryszard T. Smolenski, Ewa M. Slominska
Publikováno v:
Biology, Vol 11, Iss 5, p 675 (2022)
The disruption of the metabolism of extracellular NAD+ and NMN may affect related signaling cascades and pathologies, such as cardiovascular or respiratory system diseases. We aimed to study NAD+ and NMN hydrolysis on surface endothelial cells of div
Externí odkaz:
https://doaj.org/article/57b5eb8fb0a64c7ba25decd71c3be461
Autor:
Zaneta Smolenska, Magdalena Zabielska-Kaczorowska, Anna Wojteczek, Barbara Kutryb-Zajac, Zbigniew Zdrojewski
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
ObjectiveAmino acids (AA) and their derivatives play an integral role in the synthesis of structural and regulatory elements in human organisms and therefore pathologies such as systemic sclerosis that may alter the blood pattern of these compounds.
Externí odkaz:
https://doaj.org/article/166bc070645b4e0898132a973a0ec660
Autor:
Michela Lupia, Francesca Angiolini, Giovanni Bertalot, Stefano Freddi, Kris F. Sachsenmeier, Elisa Chisci, Barbara Kutryb-Zajac, Stefano Confalonieri, Ryszard T. Smolenski, Roberto Giovannoni, Nicoletta Colombo, Fabrizio Bianchi, Ugo Cavallaro
Publikováno v:
Stem Cell Reports, Vol 10, Iss 4, Pp 1412-1425 (2018)
Summary: Cancer-initiating cells (CICs) have been implicated in tumor development and aggressiveness. In ovarian carcinoma (OC), CICs drive tumor formation, dissemination, and recurrence, as well as drug resistance, thus accounting for the high death
Externí odkaz:
https://doaj.org/article/d9c69a527a634dd9bba0b07119e3fb1a
Publikováno v:
Molecules, Vol 25, Iss 20, p 4652 (2020)
Adenosine deaminase (ADA) is an enzyme of purine metabolism that irreversibly converts adenosine to inosine or 2′deoxyadenosine to 2′deoxyinosine. ADA is active both inside the cell and on the cell surface where it was found to interact with memb
Externí odkaz:
https://doaj.org/article/7ace6ad27ea242b29fb7ba8cc00cdf48
Autor:
Klaudia Stawarska, Alicja Braczko, Ada Kawecka, Agata Jedrzejewska, Marzena Romanowska-Kocejko, Milena Deptula, Malgorzata Zawrzykraj, Marika Franczak, Oliwia Krol, Gabriela Harasim, Michal Pikula, Marcin Hellmann, Barbara Kutryb-Zajac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cb0ad84b8e12fe7bd5e911e5c5b3ec2
https://doi.org/10.2139/ssrn.4443003
https://doi.org/10.2139/ssrn.4443003
Autor:
Michał Kunc, Pawel Romaszko, Barbara Kutryb-Zajac, Paulina Mierzejewska, Ryszard T. Smolenski, Iwona Pelikant-Malecka, Patrycja Koszałka, Magdalena Zabielska-Kaczorowska, Alicja Braczko, Ewa M. Slominska, Patrycja Jablonska, Jolanta Szade
Publikováno v:
Experimental & Molecular Medicine
Our recent studies identified a novel pathway of nicotinamide metabolism that involves 4-pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR) and demonstrated its endothelial cytotoxic effect. This study tested the effects of 4PYR and its metabolites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb881f96b49f70a944c236df03b13328
https://doi.org/10.1038/s12276-021-00669-w
https://doi.org/10.1038/s12276-021-00669-w
Autor:
Alicja Braczko, Barbara Kutryb-Zajac, Agata Jedrzejewska, Oliwia Krol, Paulina Mierzejewska, Magdalena Zabielska-Kaczorowska, Ewa M. Slominska, Ryszard T. Smolenski
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11488
Dyslipidemia triggers many severe pathologies, including atherosclerosis and chronic inflammation. Several lines of evidence, including our studies, have suggested direct effects of dyslipidemia on cardiac energy metabolism, but details of these effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26873e9a09a3fcbba0a37051e08eda1a
https://pubmed.ncbi.nlm.nih.gov/36232794
https://pubmed.ncbi.nlm.nih.gov/36232794