Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Barbara Kropff"'
Autor:
Madlen Mollik, Andreas Rohorzka, Xiaohan Chen, Barbara Kropff, Lukas Eisler, Büsra Külekci, Elisabeth Puchhammer-Stöckl, Marco Thomas, Irene Görzer
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT Cell entry is a crucial step for a virus to infect a host cell. Human cytomegalovirus utilizes glycoprotein B (gB) to fuse the viral and host cell membranes upon receptor binding of gH/gL-containing complexes. Fusion is mediated by major con
Externí odkaz:
https://doaj.org/article/5ffbab996b0a4a84ab61d0d0c352f812
Autor:
Nina Reuter, Barbara Kropff, Xiaohan Chen, William J. Britt, Heinrich Sticht, Michael Mach, Marco Thomas
Publikováno v:
Viruses, Vol 16, Iss 9, p 1482 (2024)
The human cytomegalovirus (HCMV) glycoprotein B (gB) is the viral fusogen required for entry into cells and for direct cell-to-cell spread of the virus. We have previously demonstrated that the exchange of the carboxy-terminal domain (CTD) of gB for
Externí odkaz:
https://doaj.org/article/3f1db98095cf45dfb776b7846594f3e9
Autor:
Nina Reuter, Xiaohan Chen, Barbara Kropff, Antonia Sophia Peter, William J. Britt, Michael Mach, Klaus Überla, Marco Thomas
Publikováno v:
Viruses, Vol 15, Iss 7, p 1500 (2023)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was responsible for the COVID-19 pandemic, efficiently spreads cell-to-cell through mechanisms facilitated by its membrane glycoprotein spike. We established a dual split protein (DS
Externí odkaz:
https://doaj.org/article/e7af6c58bc7b4ae4a0046f1f5be36027
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT The human cytomegalovirus (HCMV) UL132 open reading frame encodes a 270-amino-acid type I envelope glycoprotein, gpUL132. The deletion of UL132 (ΔUL132) from the HCMV genome results in a pronounced deficit in virus yield, with an approximat
Externí odkaz:
https://doaj.org/article/d9d380db92384520acac8ceb1738f9b8
Publikováno v:
Viruses, Vol 14, Iss 2, p 284 (2022)
Human cytomegalovirus (HCMV) can cause severe clinical disease in immunocompromised individuals, such as allograft recipients and infants infected in utero. Neutralizing activity of antibodies, measured as the ability to prevent the entry of cell-fre
Externí odkaz:
https://doaj.org/article/3c7ae4b529fe4c59ae8002e5cc8085f3
Autor:
Sigrun Häge, Eric Sonntag, Adriana Svrlanska, Eva Maria Borst, Anne-Charlotte Stilp, Deborah Horsch, Regina Müller, Barbara Kropff, Jens Milbradt, Thomas Stamminger, Ursula Schlötzer-Schrehardt, Manfred Marschall
Publikováno v:
Viruses, Vol 13, Iss 2, p 165 (2021)
Nuclear egress is a common herpesviral process regulating nucleocytoplasmic capsid release. For human cytomegalovirus (HCMV), the nuclear egress complex (NEC) is determined by the pUL50-pUL53 core that regulates multicomponent assembly with NEC-assoc
Externí odkaz:
https://doaj.org/article/90b6a819edab4e29a0c3c7b88eb63138
Autor:
Julia Kalser, Barbara Adler, Michael Mach, Barbara Kropff, Elisabeth Puchhammer-Stöckl, Irene Görzer
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Glycoprotein O (gO) of the human cytomegalovirus (HCMV) is the critical subunit of the envelope trimer gH/gL/gO as it interacts with platelet-derived growth factor alpha receptor upon fibroblast entry, and triggers gB-mediated fusion for fibroblast a
Externí odkaz:
https://doaj.org/article/5fb416cdfe814d53832fc010f995b15d
Autor:
Anna Bootz, Astrid Karbach, Johannes Spindler, Barbara Kropff, Nina Reuter, Heinrich Sticht, Thomas H Winkler, William J Britt, Michael Mach
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006601 (2017)
Human cytomegalovirus (HCMV) is an important, ubiquitous pathogen that causes severe clinical disease in immunocompromised individuals, such as organ transplant recipients and infants infected in utero. Antiviral chemotherapy remains problematic due
Externí odkaz:
https://doaj.org/article/90b02c7466a4442f82c693da84e90b49
Autor:
Barbara Kropff, Christiane Burkhardt, Juliane Schott, Jens Nentwich, Tanja Fisch, William Britt, Michael Mach
Publikováno v:
PLoS Pathogens, Vol 8, Iss 10, p e1002999 (2012)
Herpes viruses persist in the infected host and are transmitted between hosts in the presence of a fully functional humoral immune response, suggesting that they can evade neutralization by antiviral antibodies. Human cytomegalovirus (HCMV) encodes a
Externí odkaz:
https://doaj.org/article/bf0213ac7c284047a3d2a83404089cb3
Autor:
Thomas, Nina Reuter, Xiaohan Chen, Barbara Kropff, Antonia Sophia Peter, William J. Britt, Michael Mach, Klaus Überla, Marco
Publikováno v:
Viruses; Volume 15; Issue 7; Pages: 1500
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was responsible for the COVID-19 pandemic, efficiently spreads cell-to-cell through mechanisms facilitated by its membrane glycoprotein spike. We established a dual split protein (DS