Elucidating the cellular response of silver nanoparticles as a potential combinatorial agent for cisplatin chemotherapy

Autor: Renata Rank Miranda, Micaella Pereira da Fonseca, Barbara Korzeniowska, Lilian Skytte, Kaare Lund Rasmussen, Frank Kjeldsen

Publikováno v: Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-15 (2020)

Abstract Background Combination chemotherapy uses drugs that target different cancer hallmarks, resulting in synergistic or additive toxicity. This strategy enhances therapeutic efficacy as well as minimizes drug resistance and side effects. In this

Externí odkaz: https://doaj.org/article/a1b0af4dc0254a39b0525fbc91ba3313

Response to and recovery from treatment in human liver-mimetic clinostat spheroids: a model for assessing repeated-dose drug toxicity

Autor: Krzysztof Wrzesinski, Stephen J. Fey, Barbara Korzeniowska

Publikováno v: Toxicology Research

Medicines are usually prescribed for repeated use over shorter or longer times. Unfortunately, repeated-dose animal toxicity studies do not correlate well with observations in man. As emphasized by the ‘3Rs’ and the desire to phase-out animal res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89193b2468c85105ef8fc7bd59383166
http://europepmc.org/articles/PMC7467243

Clinostat 3D Cell Culture: Protocols for the Preparation and Functional Analysis of Highly Reproducible, Large, Uniform Spheroids and Organoids

Autor: Barbara Korzeniowska, Krzysztof Wrzesinski, Chrisna Gouws, Stephen J. Fey, Carlemi Calitz, Helle Sedighi Frandsen

Publikováno v: Methods in Molecular Biology ISBN: 9781071612453
Wrzesinski, K, Frandsen, H S, Calitz, C, Gouws, C, Korzeniowska, B & Fey, S J 2021, Clinostat 3D Cell Culture : Protocols for the Preparation and Functional Analysis of Highly Reproducible, Large, Uniform Spheroids and Organoids . in T A L Brevini, A Fazeli & K Turksen (eds), Next Generation Culture Platforms for Reliable In Vitro Models : Methods and Protocols . Humana Press, Methods in Molecular Biology, vol. 2273, pp. 17-62 . https://doi.org/10.1007/978-1-0716-1246-0_2

Growing cells as 3D structures need not be difficult. Often, it is not necessary to change cell type, additives or growth media used. All that needs to be changed is the geometry: cells (whether primary, induced pluripotent, transformed or immortal)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0ab0bdffa4401be20952ab1b3b16ef
https://doi.org/10.1007/978-1-0716-1246-0_2

Co-exposure to silver nanoparticles and cadmium induce metabolic adaptation in HepG2 cells

Autor: Barbara Korzeniowska, Stefan J. Kempf, Francisco Filipak Neto, Vladimir Gorshkov, Frank Kjeldsen, Renata Rank Miranda

Publikováno v: Nanotoxicology
Miranda, R R, Gorshkov, V, Korzeniowska, B, Kempf, S J, Neto, F F & Kjeldsen, F 2018, ' Co-exposure to silver nanoparticles and cadmium induce metabolic adaptation in HepG2 cells ', Nanotoxicology, vol. 12, no. 7, pp. 781-795 . https://doi.org/10.1080/17435390.2018.1489987

Although multiple studies have reported the toxicological effects and underlying mechanisms of toxicity of silver nanoparticles (AgNP) in a variety of organisms, the interactions of AgNP with environmental contaminants such as cadmium are poorly unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52f028f572f99f698ffda2820bd27ca
https://doi.org/10.1080/17435390.2018.1489987

Silver nanoparticle-induced expression of proteins related to oxidative stress and neurodegeneration in an in vitro human blood-brain barrier model

Autor: Barbara Korzeniowska, Vladimir Gorshkov, Lilian Skytte, Henrik Daa Schrøder, Surabhi Khandige, Frank Kjeldsen, Kaare Lund Rasmussen, Muhammad Tahir, Jakob Møller-Jensen, Asif Manzoor Khan

Publikováno v: Khan, A M, Korzeniowska, B, Gorshkov, V, Tahir, M, Schrøder, H, Skytte, L, Rasmussen, K L, Khandige, S, Møller-Jensen, J & Kjeldsen, F 2019, ' Silver nanoparticle-induced expression of proteins related to oxidative stress and neurodegeneration in an in vitro human blood-brain barrier model ', Nanotoxicology, vol. 13, no. 2, pp. 221-239 . https://doi.org/10.1080/17435390.2018.1540728
Nanotoxicology

Silver nanoparticles (AgNPs) have been reported to penetrate the central nervous system (CNS) and induce neurotoxicity. However, there is a paucity of understanding of the toxicity of AgNPs and their effect on the blood-brain barrier (BBB) including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a0e8f055b9e3dc1bec053f6ca1d25d
https://findresearcher.sdu.dk:8443/ws/files/150350904/Silver_nanoparticle_induced_expression_of_proteins_related_to_oxidative_stress_and_neurodegeneration_in_an_in_vitro_human_blood_brain_barrier_model.pdf