Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Barbara Kessler"'
Autor:
Martin Bender, Jan-Michael Abicht, Bruno Reichart, Elisabeth Neumann, Julia Radan, Maren Mokelke, Ines Buttgereit, Maria Leuschen, Felicia Wall, Sebastian Michel, Reinhard Ellgass, Stig Steen, Audrius Paskevicius, Andreas Lange, Barbara Kessler, Elisabeth Kemter, Nikolai Klymiuk, Joachim Denner, Antonia W. Godehardt, Ralf R. Tönjes, Jonathan M. Burgmann, Constança Figueiredo, Anastasia Milusev, Valentina Zollet, Neda Salimi-Afjani, Alain Despont, Robert Rieben, Stephan Ledderose, Christoph Walz, Christian Hagl, David Ayares, Eckhard Wolf, Michael Schmoeckel, Paolo Brenner, Uli Binder, Michaela Gebauer, Arne Skerra, Matthias Längin
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1927 (2024)
The blockade of the CD40/CD40L immune checkpoint is considered essential for cardiac xenotransplantation. However, it is still unclear which single antibody directed against CD40 or CD40L (CD154), or which combination of antibodies, is better at prev
Externí odkaz:
https://doaj.org/article/8c1badf713bc4998ad88ccdb88bead35
Autor:
Masahito Watanabe, Hitomaru Miyamoto, Kazutoshi Okamoto, Kazuaki Nakano, Hitomi Matsunari, Kanako Kazuki, Koki Hasegawa, Ayuko Uchikura, Shuko Takayanagi, Kazuhiro Umeyama, Yosuke Hiramuki, Elisabeth Kemter, Nikolai Klymuik, Mayuko Kurome, Barbara Kessler, Eckhard Wolf, Yasuhiro Kazuki, Hiroshi Nagashima
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 444-453 (2023)
Mammalian artificial chromosomes have enabled the introduction of extremely large amounts of genetic information into animal cells in an autonomously replicating, nonintegrating format. However, the evaluation of human artificial chromosomes (HACs) a
Externí odkaz:
https://doaj.org/article/7a8c635119da410397f678e585a6364e
Autor:
Sophia Grotz, Jessica Schäfer, Kirsten A Wunderlich, Zdenka Ellederova, Hannah Auch, Andrea Bähr, Petra Runa‐Vochozkova, Janet Fadl, Vanessa Arnold, Taras Ardan, Miroslav Veith, Gianluca Santamaria, Georg Dhom, Wolfgang Hitzl, Barbara Kessler, Christian Eckardt, Joshua Klein, Anna Brymova, Joshua Linnert, Mayuko Kurome, Valeri Zakharchenko, Andrea Fischer, Andreas Blutke, Anna Döring, Stepanka Suchankova, Jiri Popelar, Eduardo Rodríguez‐Bocanegra, Julia Dlugaiczyk, Hans Straka, Helen May‐Simera, Weiwei Wang, Karl‐Ludwig Laugwitz, Luk H Vandenberghe, Eckhard Wolf, Kerstin Nagel‐Wolfrum, Tobias Peters, Jan Motlik, M Dominik Fischer, Uwe Wolfrum, Nikolai Klymiuk
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 4, Pp n/a-n/a (2022)
Abstract Usher syndrome (USH) is the most common form of monogenic deaf‐blindness. Loss of vision is untreatable and there are no suitable animal models for testing therapeutic strategies of the ocular constituent of USH, so far. By introducing a h
Externí odkaz:
https://doaj.org/article/f0ba22f95e7b4b36b03173d767e7f90f
Autor:
Michael Stirm, Lina Marie Fonteyne, Bachuki Shashikadze, Magdalena Lindner, Maila Chirivi, Andreas Lange, Clara Kaufhold, Christian Mayer, Ivica Medugorac, Barbara Kessler, Mayuko Kurome, Valeri Zakhartchenko, Arne Hinrichs, Elisabeth Kemter, Sabine Krause, Rüdiger Wanke, Georg J. Arnold, Gerhard Wess, Hiroshi Nagashima, Martin Hrabĕ de Angelis, Florian Flenkenthaler, Levin Arne Kobelke, Claudia Bearzi, Roberto Rizzi, Andrea Bähr, Sven Reese, Kaspar Matiasek, Maggie C. Walter, Christian Kupatt, Sibylle Ziegler, Peter Bartenstein, Thomas Fröhlich, Nikolai Klymiuk, Andreas Blutke, Eckhard Wolf
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 12 (2021)
Large-animal models for Duchenne muscular dystrophy (DMD) are crucial for the evaluation of diagnostic procedures and treatment strategies. Pigs cloned from male cells lacking DMD exon 52 (DMDΔ52) exhibit molecular, clinical and pathological hallmar
Externí odkaz:
https://doaj.org/article/d8939e99103646a0a9090e1ac2200524
Autor:
Daniela Kalla, Krzysztof Flisikowski, Kaiyuan Yang, Laura Beltran Sangüesa, Mayuko Kurome, Barbara Kessler, Valeri Zakhartchenko, Eckhard Wolf, Heiko Lickert, Dieter Saur, Angelika Schnieke, Tatiana Flisikowska
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The Cre/loxP system is a powerful tool for the generation of animal models with precise spatial and temporal gene expression. It has proven indispensable in the generation of cancer models with tissue specific expression of oncogenes or the inactivat
Externí odkaz:
https://doaj.org/article/2a47aaa7c7684808befff3dda5a9b877
Autor:
Virginie Tissières, Florian Geier, Barbara Kessler, Eckhard Wolf, Rolf Zeller, Javier Lopez-Rios
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: Digit loss/reductions are evolutionary adaptations in cursorial mammals such as pigs. To gain mechanistic insight into these processes, we performed a comparative molecular analysis of limb development in mouse and pig embryos, which reveale
Externí odkaz:
https://doaj.org/article/01e3ba62cffb4d45a209cb6560090cb4
Autor:
Arne Hinrichs, Barbara Kessler, Mayuko Kurome, Andreas Blutke, Elisabeth Kemter, Maren Bernau, Armin M. Scholz, Birgit Rathkolb, Simone Renner, Sebastian Bultmann, Heinrich Leonhardt, Martin Hrabĕ de Angelis, Hiroshi Nagashima, Andreas Hoeflich, Werner F. Blum, Martin Bidlingmaier, Rüdiger Wanke, Maik Dahlhoff, Eckhard Wolf
Publikováno v:
Molecular Metabolism, Vol 11, Iss , Pp 113-128 (2018)
Objective: Laron syndrome (LS) is a rare, autosomal recessive disorder in humans caused by loss-of-function mutations of the growth hormone receptor (GHR) gene. To establish a large animal model for LS, pigs with GHR knockout (KO) mutations were gene
Externí odkaz:
https://doaj.org/article/7c74c35d25ac486abfdbf53fba4fa634
Autor:
Andreas Blutke, Simone Renner, Florian Flenkenthaler, Mattias Backman, Serena Haesner, Elisabeth Kemter, Erik Ländström, Christina Braun-Reichhart, Barbara Albl, Elisabeth Streckel, Birgit Rathkolb, Cornelia Prehn, Alessandra Palladini, Michal Grzybek, Stefan Krebs, Stefan Bauersachs, Andrea Bähr, Andreas Brühschwein, Cornelia A. Deeg, Erica De Monte, Michaela Dmochewitz, Caroline Eberle, Daniela Emrich, Robert Fux, Frauke Groth, Sophie Gumbert, Antonia Heitmann, Arne Hinrichs, Barbara Keßler, Mayuko Kurome, Miriam Leipig-Rudolph, Kaspar Matiasek, Hazal Öztürk, Christiane Otzdorff, Myriam Reichenbach, Horst Dieter Reichenbach, Alexandra Rieger, Birte Rieseberg, Marco Rosati, Manuel Nicolas Saucedo, Anna Schleicher, Marlon R. Schneider, Kilian Simmet, Judith Steinmetz, Nicole Übel, Patrizia Zehetmaier, Andreas Jung, Jerzy Adamski, Ünal Coskun, Martin Hrabě de Angelis, Christian Simmet, Mathias Ritzmann, Andrea Meyer-Lindenberg, Helmut Blum, Georg J. Arnold, Thomas Fröhlich, Rüdiger Wanke, Eckhard Wolf
Publikováno v:
Molecular Metabolism, Vol 6, Iss 8, Pp 931-940 (2017)
Objective: The prevalence of diabetes mellitus and associated complications is steadily increasing. As a resource for studying systemic consequences of chronic insulin insufficiency and hyperglycemia, we established a comprehensive biobank of long-te
Externí odkaz:
https://doaj.org/article/6df6a6d42ef44752b7265a8b82fbcbb7
Autor:
Simone Renner, Ana Sofia Martins, Elisabeth Streckel, Christina Braun-Reichhart, Mattias Backman, Cornelia Prehn, Nikolai Klymiuk, Andrea Bähr, Andreas Blutke, Christina Landbrecht-Schessl, Annegret Wünsch, Barbara Kessler, Mayuko Kurome, Arne Hinrichs, Sietse-Jan Koopmans, Stefan Krebs, Elisabeth Kemter, Birgit Rathkolb, Hiroshi Nagashima, Helmut Blum, Mathias Ritzmann, Rüdiger Wanke, Bernhard Aigner, Jerzy Adamski, Martin Hrabě de Angelis, Eckhard Wolf
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 8 (2019)
Alongside the obesity epidemic, the prevalence of maternal diabetes is rising worldwide, and adverse effects on fetal development and metabolic disturbances in the offspring's later life have been described. To clarify whether metabolic programming e
Externí odkaz:
https://doaj.org/article/ff6f3378deb84493acb73ffff823f5a4
Autor:
Svenja Opderbeck, Barbara Keßler, William Gordillio, Hansjörg Schrade, Hans-Peter Piepho, Eva Gallmann
Publikováno v:
Agriculture, Vol 11, Iss 4, p 324 (2021)
The rearing of piglets is a demanding phase of pig production partly because of the changing temperature requirements of the piglets during rearing. Piglets need high temperatures in the resting area, especially at the beginning, while the optimal te
Externí odkaz:
https://doaj.org/article/4fd3a796be5740c68049580ca6f9ca40