Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Barbara K. Brott"'
Publikováno v:
Molecular psychiatry
The threshold for Hebbian synaptic plasticity in the CNS is modulated by prior synaptic activity. At adult CA3-CA1 synapses, endocannabinoids play a role in this process, but how activity engages and maintains this retrograde signaling system is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e18cd9e0f649b3a5892db77f42cb29
https://doi.org/10.1038/s41380-018-0034-4
https://doi.org/10.1038/s41380-018-0034-4
Autor:
Akash Datwani, Carla J. Shatz, Marla B. Feller, Barbara K. Brott, Lowry A. Kirkby, Hanmi Lee, Sarah Cheng, Jaimie D. Adelson
Publikováno v:
Nature
Nature, vol 509, iss 7499
Nature, vol 509, iss 7499
The formation of precise connections between retina and lateral geniculate nucleus (LGN) involves the activity-dependent elimination of some synapses, with strengthening and retention of others. Here we show that the major histocompatibility complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23242912bb923c0c24147af50acc5ce8
http://europepmc.org/articles/PMC4016165
http://europepmc.org/articles/PMC4016165
Autor:
Carla J. Shatz, Maja Djurisic, Taeho Kim, Barbara K. Brott, Thorsten Naserke, Jaimie D. Adelson, Lijun Xu, Rona G. Giffard, Yi-Bing Ouyang, Xiaoxing Xiong, George E. Barreto
Publikováno v:
Neuron. 73:1100-1107
SummaryRecovery from stroke engages mechanisms of neural plasticity. Here we examine a role for MHC class I (MHCI) H2-Kb and H2-Db, as well as PirB receptor. These molecules restrict synaptic plasticity and motor learning in the healthy brain. Stroke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd478959fa097b0b73e11382d5ac059e
https://doi.org/10.1016/j.neuron.2012.01.020
https://doi.org/10.1016/j.neuron.2012.01.020
Autor:
Chih-Wen Chu, Sergei Y. Sokol, Jonathan Fillatre, Keiji Itoh, Olga Ossipova, Barbara K. Brott
The planar cell polarity (PCP) pathway orients cells in diverse epithelial tissues in Drosophila and vertebrate embryos and has been implicated in many human congenital defects and diseases, such as ciliopathies, polycystic kidney disease and maligna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5381d54c8fbcdca47ce51bddb13b23a3
https://europepmc.org/articles/PMC4810801/
https://europepmc.org/articles/PMC4810801/
Autor:
Barbara K. Brott, Sergei Y. Sokol
Publikováno v:
Developmental Cell. 8(5):703-715
SummaryEarly stages of vertebrate heart development have been linked to Wnt signaling. Here we show in both gain- and loss-of-function experiments that XDbf4, a known regulator of Cdc7 kinase, is an inhibitor of the canonical Wnt signaling pathway. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8917d15cd3075c5e46aabc66e43e9b
Autor:
Walid Mourad, Sophie Roy, Ann-Muriel Steff, Louis-François Bélanger, Michel J. Tremblay, Barbara K. Brott, Jean Charron, Patrice Hugo, Raymond L. Erikson
Publikováno v:
Molecular and Cellular Biology. 23:4778-4787
MEK is a dual-specificity kinase that activates the extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase upon agonist binding to receptors. The ERK/MAP kinase cascade is involved in cell fate determination in many organi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fdacbf8e10b40db718d7399772651f
https://doi.org/10.1128/mcb.23.14.4778-4787.2003
https://doi.org/10.1128/mcb.23.14.4778-4787.2003
Autor:
Maja Djurisic, Richard W. Sapp, Liqun Luo, Carla J. Shatz, Jaimie D. Adelson, Hanmi Lee, Kazunari Miyamichi, Barbara K. Brott, Sarah Cheng
Synapse pruning is an activity-regulated process needed for proper circuit sculpting in the developing brain. Major histocompatibility class I (MHCI) molecules are regulated by activity, but little is known about their role in the development of conn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6193531761a2a57bd18cf2e6a381201
https://europepmc.org/articles/PMC4785944/
https://europepmc.org/articles/PMC4785944/
Publikováno v:
Current Biology. 11(12):951-961
Background: Dickkopf-1 (Dkk-1) is a head inducer secreted from the vertebrate head organizer and induces anterior development by antagonizing Wnt signaling. Although several families of secreted antagonists have been shown to inhibit Wnt signal trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9da6e4bf1c89335194bbc3055315760
Publikováno v:
Proceedings of the National Academy of Sciences. 95:963-968
Extracellular-signal regulated kinases/microtubule-associated protein kinases (Erk/MAPKs) and cyclin-directed kinases (Cdks) are key regulators of many aspects of cell growth and division, as well as apoptosis. We have cloned a kinase, Nlk , that is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9dbe7b2efe8baec04c167f403156d90
https://doi.org/10.1073/pnas.95.3.963
https://doi.org/10.1073/pnas.95.3.963
Publikováno v:
Molecular and Cellular Biology. 11:5059-5067
GTPase-activating protein (GAP) enhances the rate of GTP hydrolysis by cellular Ras proteins and is implicated in mitogenic signal transduction. GAP is phosphorylated on tyrosine in cells transformed by Rous sarcoma virus and serves as an in vitro su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ace1c7c052e25badadc22805035837cb
https://doi.org/10.1128/mcb.11.10.5059
https://doi.org/10.1128/mcb.11.10.5059