Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Barbara K Kemp-Harper"'
Autor:
Tara E. Scott, Caitlin V. Lewis, Mingyu Zhu, Chao Wang, Chrishan S. Samuel, Grant R. Drummond, Barbara K. Kemp-Harper
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract In cardiovascular disease, pathological and protective roles are reported for the Th2 cytokines IL-4 and IL-13, respectively. We hypothesised that differential effects on macrophage function are responsible. Type I and II receptor subunit (I
Externí odkaz:
https://doaj.org/article/2a6a6a71d4aa43fea91cce8e51b240f8
Autor:
Jennifer C Irvine, Virat Ganthavee, Jane E Love, Amy E Alexander, John D Horowitz, Johannes-Peter Stasch, Barbara K Kemp-Harper, Rebecca H Ritchie
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e44481 (2012)
Although evidence now suggests cGMP is a negative regulator of cardiac hypertrophy, the direct consequences of the soluble guanylyl cyclase (sGC) activator BAY 58-2667 on cardiac remodeling, independent of changes in hemodynamic load, has not been in
Externí odkaz:
https://doaj.org/article/a9040a1e5e95429a8de0ec00ec9337c8
Autor:
Eliane Q Lin, Jennifer C Irvine, Anh H Cao, Amy E Alexander, Jane E Love, Ruchi Patel, Julie R McMullen, David M Kaye, Barbara K Kemp-Harper, Rebecca H Ritchie
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34892 (2012)
New therapeutic targets for cardiac hypertrophy, an independent risk factor for heart failure and death, are essential. HNO is a novel redox sibling of NO• attracting considerable attention for the treatment of cardiovascular disorders, eliciting c
Externí odkaz:
https://doaj.org/article/427f18f2e76e435489b1f01e2a2a8fad
Autor:
Fariha Alam, Tracey A. Gaspari, Barbara K. Kemp-Harper, Edward Low, Aaron Aw, Dorota Ferens, Iresha Spizzo, Ann-Maree Jefferis, Praveen Praveen, Robert E. Widdop, Ross A.D. Bathgate, Mohammed Akhter Hossain, Chrishan S. Samuel
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 160, Iss , Pp 114370- (2023)
The hormone, relaxin (RLX), exerts various organ-protective effects independently of etiology. However, its complex two-chain and three disulphide bonded structure is a limitation to its preparation and affordability. Hence, a single chain-derivative
Externí odkaz:
https://doaj.org/article/5ab983e3650b46eba55d98f76cfcbf69
Autor:
Yang Liu, Kevin D. Croft, Trevor A. Mori, Tracey A. Gaspari, Barbara K. Kemp-Harper, Natalie C. Ward
Publikováno v:
European Journal of Nutrition. 62:1845-1857
Background and aims Atherosclerosis is associated with a reduction in the bioavailability and/or bioactivity of endogenous nitric oxide (NO). Dietary nitrate has been proposed as an alternate source when endogenous NO production is reduced. Our previ
Autor:
Jasmin Chendi Li, Anida Velagic, Cheng Xue Qin, Mandy Li, Chen Huei Leo, Barbara K. Kemp-Harper, Rebecca H. Ritchie, Owen L. Woodman
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Introduction:Endothelial dysfunction is a major risk factor for several of the vascular complications of diabetes, including ischemic stroke. Nitroxyl (HNO), the one electron reduced and protonated form of nitric oxide (NO•), is resistant to scaven
Externí odkaz:
https://doaj.org/article/00f50aad06064c38b7a63a4ffc1a2c6e
Autor:
Alex Peh, Evany Dinakis, Hamdi Jama, Dovile Anderson, Darren J. Creek, Gang Zheng, Michael de Veer, Charles R. Mackay, Tenghao Zheng, Barbara K. Kemp-Harper, Brad R.S. Broughton, Francine Z. Marques
Dietary fibre intake is associated with fewer cases of ischaemic stroke. This is likely via the microbiota-gut-brain axis, where fibre is fermented by the gut microbiota, releasing short-chain fatty acids (SCFAs). However, whether fibre or SCFAs can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6c0f2d103e92eb9e8ec5f32da4c9cac
https://doi.org/10.1101/2023.05.15.540735
https://doi.org/10.1101/2023.05.15.540735
Autor:
Alex Peh, Evany Dinakis, Michael Nakai, Rikeish R. Muralitharan, Samoda Rupasinghe, Jenny L. Wilson, Connie H.Y. Wong, Hamdi Jama, Charlotte M.O. Barker, Mahnaz Modarresi, Barbara K. Kemp-Harper, Tenghao Zheng, Francine Z. Marques, Brad R.S. Broughton
We provide evidence that stroke-induced gut breakdown results in bacteria translocation to the ischaemic mouse brain. Inhibition of sympathetic tone reduced bacterial load in the post-stroke brain and reduced functional deficits without altering cere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a29fe23fc5fc2502e6e96bc7f7c58d57
https://doi.org/10.1101/2023.04.03.535309
https://doi.org/10.1101/2023.04.03.535309
Autor:
Anida Velagic, Mandy Li, Minh Deo, Jasmin Chendi Li, Helen Kiriazis, Daniel G. Donner, Dovile Anderson, Miles J. De Blasio, Owen L. Woodman, Barbara K. Kemp-Harper, Cheng Xue Qin, Rebecca H. Ritchie
Publikováno v:
American journal of physiology. Heart and circulatory physiology.
Left ventricular (LV) dysfunction is an early, clinically detectable sign of cardiomyopathy in type 2 diabetes mellitus (T2DM) that precedes the development of symptomatic heart failure. Pre-clinical models of diabetic cardiomyopathy are essential to
Publikováno v:
Hypertension. 78:1168-1184
Pulmonary hypertension is a rare, ostensibly incurable, and etiologically diverse disease with an unacceptably high 5-year mortality rate (≈50%), worse than many cancers. Irrespective of pathogenic origin, dysregulated immune processes underlie pul