Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Barbara K, Lipska"'
Autor:
Anton Schulmann, Stefano Marenco, Marquis P. Vawter, Nirmala Akula, Agenor Limon, Ajeet Mandal, Pavan K. Auluck, Yash Patel, Barbara K. Lipska, Francis J. McMahon
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Recent postmortem transcriptomic studies of schizophrenia (SCZ) have shown hundreds of differentially expressed genes. However, the extent to which these gene expression changes reflect antipsychotic drug (APD) exposure remains uncertain. We
Externí odkaz:
https://doaj.org/article/6c8d3909b4f74186bcb9e6b84c0ae689
Autor:
Lide Han, Xuefang Zhao, Mary Lauren Benton, Thaneer Perumal, Ryan L. Collins, Gabriel E. Hoffman, Jessica S. Johnson, Laura Sloofman, Harold Z. Wang, Matthew R. Stone, CommonMind Consortium, Kristen J. Brennand, Harrison Brand, Solveig K. Sieberts, Stefano Marenco, Mette A. Peters, Barbara K. Lipska, Panos Roussos, John A. Capra, Michael Talkowski, Douglas M. Ruderfer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Structural variants (SVs) contribute to the genetic architecture of many brain-related disorders. Here, the authors integrate SV calls from genome sequencing (n = 755) with RNA-seq data (n = 629) from post-mortem dorsal lateral prefrontal cortex to a
Externí odkaz:
https://doaj.org/article/d5da8027a19c4487875263a8dbf5c81b
Autor:
Kiran, Girdhar, Gabriel E, Hoffman, Jaroslav, Bendl, Samir, Rahman, Pengfei, Dong, Will, Liao, Mads E, Hauberg, Laura, Sloofman, Leanne, Brown, Olivia, Devillers, Bibi S, Kassim, Jennifer R, Wiseman, Royce, Park, Elizabeth, Zharovsky, Rivky, Jacobov, Elie, Flatow, Alexey, Kozlenkov, Thomas, Gilgenast, Jessica S, Johnson, Lizette, Couto, Mette A, Peters, Jennifer E, Phillips-Cremins, Chang-Gyu, Hahn, Raquel E, Gur, Carol A, Tamminga, David A, Lewis, Vahram, Haroutunian, Stella, Dracheva, Barbara K, Lipska, Stefano, Marenco, Marija, Kundakovic, John F, Fullard, Yan, Jiang, Panos, Roussos, Schahram, Akbarian
Publikováno v:
Girdhar, K, Hoffman, G E, Bendl, J, Rahman, S, Dong, P, Liao, W, Hauberg, M E, Sloofman, L, Brown, L, Devillers, O, Kassim, B S, Wiseman, J R, Park, R, Zharovsky, E, Jacobov, R, Flatow, E, Kozlenkov, A, Gilgenast, T, Johnson, J S, Couto, L, Peters, M A, Phillips-Cremins, J E, Hahn, C G, Gur, R E, Tamminga, C A, Lewis, D A, Haroutunian, V, Dracheva, S, Lipska, B K, Marenco, S, Kundakovic, M, Fullard, J F, Jiang, Y, Roussos, P, Akbarian, S & PsychENCODE Consortium 2022, ' Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains ', Nature Neuroscience, vol. 25, no. 4, pp. 474-483 . https://doi.org/10.1038/s41593-022-01032-6
Chromosomal organization, scaling from the 147-base pair (bp) nucleosome to megabase-ranging domains encompassing multiple transcriptional units, including heritability loci for psychiatric traits, remains largely unexplored in the human brain. In th
Autor:
Zongyang Mou, Thomas M. Hyde, Barbara K. Lipska, Keri Martinowich, Peter Wei, Chiew-Jen Ong, Lindsay A. Hunter, Gladys I. Palaguachi, Eva Morgun, Rujia Teng, Chen Lai, Tania A. Condarco, Andrew P. Demidowich, Amanda J. Krause, Leslie J. Marshall, Karin Haack, V. Saroja Voruganti, Shelley A. Cole, Nancy F. Butte, Anthony G. Comuzzie, Michael A. Nalls, Alan B. Zonderman, Andrew B. Singleton, Michele K. Evans, Bronwen Martin, Stuart Maudsley, Jack W. Tsao, Joel E. Kleinman, Jack A. Yanovski, Joan C. Han
Publikováno v:
Cell Reports, Vol 13, Iss 6, Pp 1073-1080 (2015)
Brain-derived neurotrophic factor (BDNF) plays a key role in energy balance. In population studies, SNPs of the BDNF locus have been linked to obesity, but the mechanism by which these variants cause weight gain is unknown. Here, we examined human hy
Externí odkaz:
https://doaj.org/article/fc8a326f318f451da933e0b55b35b1af
Autor:
C. Harker Rhodes, Barbara K. Lipska, Sevilla D. Detera-Wadleigh, Qing Xu, Kory R. Johnson, Pavan Auluck, Bryce England, Jose A. Apud, Aparna Nathan, Brent T. Harris, Stefano Marenco, Kwangmi An, Robin Kramer, Winston Corona, Francis J. McMahon, Joanna Cross, Kevin Zhu, Anton Schulmann, Nirmala Akula, Ningping Feng, Xueying Jiang
Publikováno v:
Neuropsychopharmacology
Despite strong evidence of heritability and growing discovery of genetic markers for major mental illness, little is known about how gene expression in the brain differs across psychiatric diagnoses, or how known genetic risk factors shape these diff
Autor:
Kasey N Davis, Ran Tao, Chao Li, Yuan Gao, Marjorie C Gondré-Lewis, Barbara K Lipska, Joo Heon Shin, Bin Xie, Tianzhang Ye, Daniel R Weinberger, Joel E Kleinman, Thomas M Hyde
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148558 (2016)
Genetic variation and early adverse environmental events work together to increase risk for schizophrenia. γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in adult mammalian brain, plays a major role in normal brain development, an
Externí odkaz:
https://doaj.org/article/926f2e0d97124c0cbe63aa2c7ed33b09
Autor:
Yan Jiang, Tyler M. Borrman, Jennifer Wiseman, Gabriella Hutta, Tobias B. Halene, Cyril J. Peter, Nadejda M. Tsankova, Pavan Auluck, John F. Crary, Sergio Espeso-Gil, Neda Shokrian, Jaroslav Bendl, Behnam Javidfar, Alanna C. Cote, Sandhya Chandrasekaran, Schahram Akbarian, Stefano Marenco, Michael J. Bannon, Panagiotis Roussos, Aaron J Bell, Rebecca Birnbaum, Bibi Kassim, Barbara K. Lipska, Prashanth Rajarajan, Laura M. Huckins, Will Liao, Marina Iskhakova, Zhiping Weng
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-19 (2020)
Genome Medicine
Genome Medicine
Background Midbrain dopaminergic neurons (MDN) represent 0.0005% of the brain’s neuronal population and mediate cognition, food intake, and metabolism. MDN are also posited to underlay the neurobiological dysfunction of schizophrenia (SCZ), a sever
Autor:
Samir Rahman, Yan Jiang, Kiran Girdhar, Haroutunian, Pengfei Dong, Mette A. Peters, E Flatow, Chang-Gyu Hahn, Stella Dracheva, John F. Fullard, Schahram Akbarian, Barbara K. Lipska, R.E. Gur, Stefano Marenco, Couto L, Elizabeth Zharovsky, Royce Park, David A. Lewis, Gabriel E. Hoffman, Bibi Kassim, Alex Kozlenkov, Panagiotis Roussos, Carol A. Tamminga, Leanne Brown, Wiseman, Jaroslav Bendl, Thomas G. Gilgenast, Will Liao, Devillers O, Jessica S. Johnson, Marija Kundakovic, Jennifer E. Phillips-Cremins, Rivka Jacobov
To explore modular organization of chromosomes in schizophrenia (SCZ) and bipolar disorder (BD), we applied ‘population-scale’ correlational structuring of 739 histone H3-lysine 27 acetylation and H3-lysine 4 trimethylation profiles, generated fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb166c3df7dbce9f336a5660822ff83c
https://doi.org/10.1101/2021.06.02.446728
https://doi.org/10.1101/2021.06.02.446728
Autor:
Francis J. McMahon, Stefano Marenco, Pavan Auluck, Anton Schulmann, Barbara K. Lipska, Nirmala Akula
Publikováno v:
Biological Psychiatry. 89:S118-S119
Autor:
Pavan Auluck, Amna Zehra, David Goldman, Nora D. Volkow, Ningping Feng, Christine Muench, Gene-Jack Wang, Hui Sun, Corinde E. Wiers, Stefano Marenco, Falk W. Lohoff, Jisoo Lee, Clara Freeman, James M. Swanson, Barbara K. Lipska
Publikováno v:
European Journal of Neuroscience. 48:1884-1895
Dopamine transporters (DAT) are implicated in the pathogenesis and treatment of attention deficit hyperactivity disorder (ADHD) and are upregulated by chronic treatment with methylphenidate, commonly prescribed for ADHD. Methylation of the DAT1 gene