Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Barbara J. Robertson"'
Autor:
Ivar M. McDonald, Robert A. Mate, Debra J. Post-Munson, Meredith Ferrante, David G. Harden, Lizbeth Gallagher, Richard E. Olson, F. Christopher Zusi, Barbara J. Robertson, Steven I. Dworetzky, Daniel G. Morgan, Hong Huang, Ronald J. Knox, Nicholas J. Lodge, John E. Macor, Robert L. Bertekap
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1684-1688
High throughput screening led to the identification of a novel series of quinolone α7 nicotinic acetylcholine receptor (nAChR) agonists. Optimization of an HTS hit (1) led to 4-phenyl-1-(quinuclidin-3-ylmethyl)quinolin-2(1H)-one, which was found to
Autor:
Barbara J. Robertson, Ming Zheng, Alice Loo, Jian Wang, Jason A. Corsa, David W. Smith, Susan B. Roberts, Shikha Vig, Joseph P. Hendrick, Qi Gao, Suresh Yeola, Bogdan Sleczka, Craig Polson, Donna M. Barten, Valerie Guss, Bergstrom Carl P, Charles Dangler, C.V.C. Prasad
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4006-4011
We report on the design of benzodiazepinones as peptidomimetics at the carboxy terminus of hydroxyamides. Structure-activity relationships of diazepinones were investigated and orally active gamma-secretase inhibitors were synthesized. Active metabol
Autor:
David Smith, James Loy, Joseph P. Hendrick, Kevin M. Felsenstein, Barbara J. Robertson, Jeffery J. Anderson, Jason A. Corsa, Ming Zheng, Benito Munoz, Donna M. Barten, Steven Hansel, Todd A Verdoorn, Valerie Guss, Alice T. Loo, Rex Denton, Craig Polson, Kumar Srinivasan, Jian Wang, Susan B. Roberts, Bowei Wang
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 312:635-643
gamma-Secretase inhibitors are one promising approach to the development of a therapeutic for Alzheimer's disease (AD). gamma-Secretase inhibitors reduce brain beta-amyloid peptide (Abeta), which is believed to be a major contributor in the etiology
Autor:
Svetlana Tertyshnikova, Susan B. Roberts, Lav K. Parvathenani, Barbara J. Robertson, Rand Posmantur, Corinne R. Greco
Publikováno v:
Journal of Biological Chemistry. 278:13309-13317
Primary rat microglia stimulated with either ATP or 2'- and 3'-O-(4-benzoylbenzoyl)-ATP (BzATP) release copious amounts of superoxide (O(2)(-)*). ATP and BzATP stimulate O(2)(-)* production through purinergic receptors, primarily the P2X(7) receptor.
Publikováno v:
Brain Research. 838:234-240
Previous research has shown that hippocampal and neocortical activation accompanies the postural changes occurring during self-grooming in rats but is absent or reduced during the stereotyped components of grooming, including head-washing and licking
Publikováno v:
Journal of Virology. 71:1683-1687
The herpes simplex virus type 1 (HSV-1) protease and its substrate, the assembly protein ICP35, are involved in virion maturation. Both proteins are encoded by a single open reading frame but are translated independently from 3'-coterminal mRNAs of d
Autor:
Xuanchuan Yu, Maricar Miranda, Yuval Blat, Barbara J. Robertson, Lisa Hunihan, Caroline Fanslau, Bradley C. Pearce, Donna L. Pedicord, Michael J. Flynn, Ryan Westphal
Publikováno v:
Biochemical and biophysical research communications. 411(4)
Diacylglycerol lipase α is the key enzyme in the formation of the most prevalent endocannabinoid, 2-arachidonoylglycerol in the brain. In this study we identified the catalytic triad of diacylglycerol lipase α, consisting of serine 472, aspartate 5
Autor:
John P. Corradi, Jeremy H. Toyn, C.V.C. Prasad, Richard E. Olson, Vanessa Hay, Barbara J. Robertson, Lynn A. Balanda, Robert Zaczek, Lawrence G. Iben, Charles F. Albright, Sukhanya Jayachandra
Publikováno v:
The Journal of biological chemistry. 282(51)
The enzyme gamma-secretase has long been considered a potential pharmaceutical target for Alzheimer disease. Presenilin (the catalytic subunit of gamma-secretase) and signal peptide peptidase (SPP) are related transmembrane aspartyl proteases that cl
Identification and characterization of compounds that potentiate NT-3-mediated Trk receptor activity
Autor:
Diana L. Franco, Barbara J. Robertson, Lisa Hunihan, Yi Li, Ryan Westphal, Jane Palmer, Denis R. St. Laurent, Balu Balasubramanian, Martin A. Lewis
Publikováno v:
Molecular pharmacology. 69(4)
Neurotrophins are a family of secreted proteins that play an important role in the development, differentiation, and survival of neurons. Studies also suggest that aberrant neurotrophin signaling may play a role in processes underlying disease states
Autor:
Mary Ellen K. Salyan, John N. Feder, Barbara J. Robertson, Ryan Westphal, Lynn A. Balanda, Laurie Bergeron, Gabe Mintier, Petia Shipkova, Kathy Kuit, Yuval Blat, Lisa Hunihan, Donna L. Pedicord
Publikováno v:
Analytical biochemistry. 349(1)
Methyltransferases form a large class of enzymes, most of which use S-adenosylmethionine as the methyl donor. In fact, S-adenosylmethionine is second only to ATP in the variety of reactions for which it serves as a cofactor. Several methods to measur