Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Barbara J. Ring"'
Autor:
Claire H. Li, Steven A. Wrighton, Jessica A. Roseberry Baker, Olukayode A. Oluyedun, Yingying Guo, Barbara J. Ring, Anne H. Dantzig, Yue-Wei Qian, Stephen D. Hall, Enaksha R Wickremsinhe
Publikováno v:
Drug Metabolism and Disposition. 41:541-545
Gemcitabine (dFdC, 2',2'-difluorodeoxycytidine) is metabolized by cytidine deaminase (CDA) and deoxycytidine kinase (DCK), but the contribution of genetic variation in these enzymes to the variability in systemic exposure and response observed in can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81358e1fe9b42b3eb56a768cb1b3acb6
https://doi.org/10.1124/dmd.112.048769
https://doi.org/10.1124/dmd.112.048769
Autor:
Volker Fischer, Christopher R. Gibson, Handan He, Kimberly K. Adkison, Patrick Poulin, Hannah M. Jones, Sandeep Dutta, Rhys D.O. Jones, M. Sherry Ku, Vikash K. Sinha, Ragini Vuppugalla, Punit Marathe, Thierry Lavé, Jenny Y. Chien, Malcolm Rowland, Thorir Björnsson, Barbara J. Ring, James W.T. Yates
Publikováno v:
Journal of Pharmaceutical Sciences. 100:4127-4157
The objective of this study is to assess the effectiveness of physiologically based pharmacokinetic (PBPK) models for simulating human plasma concentration-time profiles for the unique drug dataset of blinded data that has been assembled as part of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91bdc12078547300aa1028103356b9d8
https://doi.org/10.1002/jps.22550
https://doi.org/10.1002/jps.22550
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 43(12)
In vitro assays using liver subcellular fractions or suspended hepatocytes for characterizing the metabolism of drug candidates play an integral role in the optimization strategy employed by medicinal chemists. However, conventional in vitro assays h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7645a715ed5af629c00de95f465e992b
https://pubmed.ncbi.nlm.nih.gov/26363026
https://pubmed.ncbi.nlm.nih.gov/26363026
Autor:
Todd D. Porter, Guy Russo, Paul Silber, Peter J. Wedlund, Li Li, Barbara J. Ring, John B. Heim, John A. Tine, Run-Mei Pan, Neil S. Jensen
Publikováno v:
Drug Metabolism and Disposition. 34:1411-1416
Genotype/phenotype analysis with human hepatocytes has identified a new inactive CYP2D6 allele, CYP2D6*56. Cryopreserved human hepatocytes from 51 livers were evaluated for CYP2D6 activity with dextromethorphan as the probe substrate. Hepatocyte lots
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e19d88180517f3ac9d17b91ee8085cb
https://doi.org/10.1124/dmd.106.009548
https://doi.org/10.1124/dmd.106.009548
Publikováno v:
Pharmaceutical Research. 23:654-662
The utility of in vitro metabolism to accurately predict the clearance of hepatically metabolized drugs was evaluated. Three major goals were: (1) to optimize substrate concentration for the accurate prediction of clearance by comparing to K m value,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad4e41c8ee228869142546751256f13
https://doi.org/10.1007/s11095-006-9663-4
https://doi.org/10.1007/s11095-006-9663-4
Autor:
Beverley E. Patterson, Alun Bedding, Mark Vandenbranden, James A. Eckstein, Steven A. Wrighton, Malcolm I. Mitchell, S. Thomas Forgue, Jennifer S. Gillespie, Diane L. Phillips, Barbara J. Ring, Hayley Jewell, Christopher D. Payne
Publikováno v:
Clinical Pharmacology & Therapeutics. 77:63-75
Objectives Tadalafil was examined in vitro and in vivo for its ability to affect human cytochrome P450 (CYP) 3A-mediated metabolism. Methods Reversible and mechanism-based inhibition of CYP3A by tadalafil was examined in human liver microsomes. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3406d6f3e20df0a44decddbccb1bb86
https://doi.org/10.1016/j.clpt.2004.09.006
https://doi.org/10.1016/j.clpt.2004.09.006
Autor:
Charles B. Jensen, Barbara J. Ring, Brian P. Smith, Holly A. Read, Jennifer Witcher, Steven A. Wrighton, Nathan P. Sanburn, Karl A. DeSante, Amanda J. Long, John-Michael Sauer, Jennifer S. Gillespie, David M. Petullo, Mark Vandenbranden
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 308:410-418
In the studies reported here, the ability of atomoxetine hydrochloride (Strattera) to inhibit or induce the metabolic capabilities of selected human isoforms of cytochrome P450 was evaluated. Initially, the potential of atomoxetine and its two metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2723fba95687bf0fb88521d706313d2f
https://doi.org/10.1124/jpet.103.058727
https://doi.org/10.1124/jpet.103.058727
Autor:
Jatinder K. Lamba, Stephen C. Strom, Vishal Lamba, Peter K. Rogan, Kazuto Yasuda, Michael L. Hancock, Barbara J. Ring, Julio C. Davila, Steven A. Wrighton, James D. Fackenthal, Erin G. Schuetz
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 307:906-922
CYP2B6 metabolizes many drugs, and its expression varies greatly. CYP2B6 genotype-phenotype associations were determined using human livers that were biochemically phenotyped for CYP2B6 (mRNA, protein, and CYP2B6 activity), and genotyped for CYP2B6 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d378ec2ca4da6b801ca0938f937481d9
https://doi.org/10.1124/jpet.103.054866
https://doi.org/10.1124/jpet.103.054866
Autor:
Steven A. Wrighton, Barbara J. Ring, Jennifer S. Gillespie, Kristina M. Campanale, S N Binkley
Publikováno v:
Drug Metabolism and Disposition. 30:957-961
Studies were performed to determine the cytochromes P450 (P450) responsible for the biotransformation of (S)-13[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc165eb6116d8f3e3c9903dd254bb52
https://doi.org/10.1124/dmd.30.9.957
https://doi.org/10.1124/dmd.30.9.957
Autor:
Steven A. Wrighton, Varon E. Cantrell, Barbara J. Ring, James A. Eckstein, J. Andrew Williams, Stephen D. Hall, Mitchell A. Hamman, David R. Jones, Kenneth J. Ruterbories
Publikováno v:
Drug Metabolism and Disposition. 30:883-891
The human cytochromes P450 (P450) CYP3A contribute to the biotransformation of 50% of oxidatively metabolized drugs. The predominant hepatic form is CYP3A4, but recent evidence indicates that CYP3A5 contributes more significantly to the total liver C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e950f2897b9bdc604c25669f243855
https://doi.org/10.1124/dmd.30.8.883
https://doi.org/10.1124/dmd.30.8.883