Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Barbara J. Palazuk"'
Autor:
Heinrich J. Schostarez, F. Craig Stevens, John E. Bleasdale, Theresa J. O’Sullivan, Scott D. Larsen, Charlotta Liljebris, Derek Ogg, Barbara J. Palazuk, Tjeerd Barf, Paul D. May
Publikováno v:
Journal of Medicinal Chemistry. 45:598-622
Protein tyrosine phosphatase 1B (PTP1B) negatively regulates insulin signaling in part by dephosphorylating key tyrosine residues within the regulatory domain of the beta-subunit of the insulin receptor (IR), thereby attenuating receptor tyrosine kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cec9ff7a74c33d8e12ec80028a71a4
https://doi.org/10.1021/jm010393s
https://doi.org/10.1021/jm010393s
Publikováno v:
Diabetes. 44:43-48
The regulation of hexokinase II (HKII) was examined in fat and skeletal muscle of an animal model of non-insulin-dependent diabetes mellitus, the KKAY mouse. These tissues require insulin for facilitated transport of glucose and express the insulin-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3690befef80f7f97e2a5619393e6c2
https://doi.org/10.2337/diab.44.1.43
https://doi.org/10.2337/diab.44.1.43
Autor:
G S Hotamisligil, Jerry R. Colca, S S Braithwaite, Bruce M. Spiegelman, Kathryn Lorenz, Barbara J. Palazuk, Cecilia Hofmann
Publikováno v:
Endocrinology. 134:264-270
As obesity is a major risk factor for noninsulin-dependent diabetes mellitus, adipose tissue may generate a mediator that influences the activity of insulin on various target tissues. Recent evidence suggests that a cytokine, tumor necrosis factor-al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56a3ee130dfb98202c85c3d83d932b3
https://doi.org/10.1210/endo.134.1.8275942
https://doi.org/10.1210/endo.134.1.8275942
Autor:
F.Craig Stevens, Thomas J. Lindberg, John E. Bleasdale, Barbara J. Palazuk, Heinrich J. Schostarez, Theresa J. O'Sullivan, Paul M. Bodnar, Scott D. Larsen
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(5)
Low molecular weight peptidomimetic compounds based on O-malonyl tyrosine and O-carboxymethyl salicylic acid are potent inhibitors of PTP1B. Modifications of the N-terminal Boc-Phe moiety were undertaken in an effort to improve physical chemical prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd1f0fd64e641b7bf9a46c092069870
https://pubmed.ncbi.nlm.nih.gov/12617932
https://pubmed.ncbi.nlm.nih.gov/12617932
Autor:
M.L Swanson, C.W Smith, Heinrich J. Schostarez, Camilla I. Svensson, X.Y Wang, Carol A. Bannow, Charlotta Liljebris, John E. Bleasdale, C.S Jacob, Barbara J. Palazuk, A Heijbel, Derek Ogg, A.L Laborde, D.P Thompson, F.C Stevens, P.D May, W.R Mathews, C.W Stuchly, R.A Conradi, Scott D. Larsen, K Bergdahl
Publikováno v:
Biochemistry. 40(19)
Protein tyrosine phosphatase 1B (PTP1B) attenuates insulin signaling by catalyzing dephosphorylation of insulin receptors (IR) and is an attractive target of potential new drugs for treating the insulin resistance that is central to type II diabetes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0ee39f93b9c70da37d491803055340
https://pubmed.ncbi.nlm.nih.gov/11341829
https://pubmed.ncbi.nlm.nih.gov/11341829
Publikováno v:
Metabolism: clinical and experimental. 44(3)
This study aimed to demonstrate directly that the thiazolidinedione pioglitazone acts as an insulin sensitizer. We tested the hypothesis that pioglitazone treatment of diabetic rats alters liver function such that responsiveness of selected genes to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b7f8f1c7178e24922c4a3fa0f44e56
https://pubmed.ncbi.nlm.nih.gov/7885286
https://pubmed.ncbi.nlm.nih.gov/7885286
Autor:
Jerry R. Colca, James D. Pearson, Daryll B. DeWald, Barbara J. Palazuk, Jay M. McDonald, Joseph P. Laurino
Publikováno v:
Journal of Biological Chemistry. 262:11399-11402
Phosphorylation of cellular proteins is known to play an important role in mediating the metabolic effects of insulin in target cells. Here we show that exposure of intact adipocytes to physiological concentrations of insulin results in phosphorylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2ab86aefa7738dc44031785f13e9bfa
https://doi.org/10.1016/s0021-9258(18)60818-x
https://doi.org/10.1016/s0021-9258(18)60818-x
Autor:
Jerry R. Colca, James D. Pearson, Patricia A. Pierce-Ramsey, Barbara J. Palazuk, Mark C. McCroskey
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1011:212-219
Crude preparations of histones had insulin-like actions in isolated adipocytes. This activity was attributed to the arginine-rich histones, H3 and H4. The metabolic effects of purified H3 and H4 on isolated adipocytes were similar to those of insulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc634cf5f6677a964f522df94ddf42c4
https://doi.org/10.1016/0167-4889(89)90212-7
https://doi.org/10.1016/0167-4889(89)90212-7
Autor:
G. A. Sawada, K. S. Jodelis, Jerry R. Colca, A. R. Diani, Beatrice M. Wyse, B.L. Fletcher-McGruder, C. L. Connell, Barbara J. Palazuk
Publikováno v:
Metabolism. 37:276-280
Chronic administration of ciglitazone (5-4[1-methyl-cyclohexylmethoxy)-benzyl]-thiazolidine-2,4 dione) decreased both plasma glucose and insulin concentrations in ob/ob mice. When given as an admixture to the feed, blood glucose levels were reduced a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6349e1c58681d84333fa564867c00e5a
https://doi.org/10.1016/0026-0495(88)90108-4
https://doi.org/10.1016/0026-0495(88)90108-4