Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Barbara J. Holt"'
Autor:
James F. Read, Michael Serralha, Danny Mok, Barbara J. Holt, Mark Cruickshank, Yuliya V. Karpievitch, David I. Broadhurst, Peter D. Sly, Deborah H. Strickland, Stacey N. Reinke, Patrick G. Holt, Anthony Bosco
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Appropriate innate immune function is essential to limit pathogenesis and severity of severe lower respiratory infections (sLRI) during infancy, a leading cause of hospitalization and risk factor for subsequent asthma in this age group. Employing a s
Externí odkaz:
https://doaj.org/article/19215fb031644d0b88e4185829ef6ec3
Autor:
Qin Qin Huang, Howard H. F. Tang, Shu Mei Teo, Danny Mok, Scott C. Ritchie, Artika P. Nath, Marta Brozynska, Agus Salim, Andrew Bakshi, Barbara J. Holt, Chiea Chuen Khor, Peter D. Sly, Patrick G. Holt, Kathryn E. Holt, Michael Inouye
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Some immune-mediated diseases may originate in early childhood. The authors mapped eQTLs and response eQTLs to various stimuli in neonatal myeloid cells and T cells, and revealed their potential role in immune-mediated diseases using colocalisation a
Externí odkaz:
https://doaj.org/article/4fd74a8582194eebb54003eaafc6eecf
Autor:
Keith J. Chappell, Patrick G. Holt, Stephen B. Lambert, Merci M.H. Kusel, Daniel Watterson, Paul R. Young, Keith Grimwood, Barbara J. Holt, Mari Takashima, Robert S. Ware, Peter D. Sly
Publikováno v:
Pediatric Pulmonology. 56:3942-3951
OBJECTIVE: To determine the potential longer-term effects of maternal antenatal respiratory syncytial virus (RSV) vaccination, we examined the association between cord-blood RSV-neutralizing antibodies (RSV-NA) and RSV infections in the first 2-years
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2af9cc6568f8fcb836ab1c8c1a7a2a
https://doi.org/10.1002/ppul.25688
https://doi.org/10.1002/ppul.25688
Autor:
Patrick G. Holt, Michael Serralha, Anya C. Jones, Dominic Mallon, Anthony Bosco, Rochelle Hartmann, Denise Anderson, Barbara J. Holt, Niamh M. Troy
Publikováno v:
Allergy. 75:2330-2341
Background Multiple regulatory mechanisms have been identified employing conventional hypothesis-driven approaches as contributing to allergen-specific immunotherapy outcomes, but understanding of how these integrate to maintain immunological homeost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b71264af563f39c47582a328a08bc2
https://doi.org/10.1111/all.14265
https://doi.org/10.1111/all.14265
Autor:
Deborah H. Strickland, Sally Galbraith, Anya C. Jones, Denise Anderson, Barbara J. Holt, Peter D. Sly, Emmanuelle Fantino, Michael Serralha, Diana Gutierrez Cardenas, Patrick G. Holt, Anthony Bosco, James F. Read
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 199:1537-1549
Rationale: A subset of infants are hypersusceptible to severe/acute viral bronchiolitis (AVB), for reasons incompletely understood. Objectives: To characterize the cellular/molecular mechanisms underlying infant AVB in circulating cells/local airway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3550c167de277c313db70c6751881c8d
https://doi.org/10.1164/rccm.201804-0715oc
https://doi.org/10.1164/rccm.201804-0715oc
Autor:
Scott C. Ritchie, Shu Mei Teo, Agus Salim, Marta Brozynska, Michael Inouye, Chiea Chuen Khor, Howard H.F. Tang, Patrick G. Holt, Danny Mok, Barbara J. Holt, Andrew Bakshi, Qin Qin Huang, Artika P. Nath, Peter D. Sly, Kathryn E. Holt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we map expression quantitative trait loci (eQTLs) in resting myeloid cells and CD4+ T cells f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fab7478af111684e2e5e475cdba722a
https://www.repository.cam.ac.uk/handle/1810/309611
https://www.repository.cam.ac.uk/handle/1810/309611
Publikováno v:
The Journal of allergy and clinical immunology. 144(3)
Severe lower respiratory illnesses (sLRI) during infancy increase the risk of asthma. The immunomodulator BronchVaxom® can increase the time to the first sLRI and reduce the cumulative burden of sLRI in "at risk" infants.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79d2f32cc9e79f17786987d72ca17b9
https://pubmed.ncbi.nlm.nih.gov/31185221
https://pubmed.ncbi.nlm.nih.gov/31185221
Autor:
Emmanuelle Fantino, Deborah H. Strickland, Peter D. Sly, Sally Galbraith, Anya C. Jones, James F. Read, Denise Anderson, Diana Gutierrez Cardenas, Michael Serralha, Barbara J. Holt, Patrick G. Holt, Anthony Bosco
Publikováno v:
The Journal of allergy and clinical immunology. 144(5)
Febrile lower respiratory infections trigger uniquely potent/complex immunoinflammatory responses in infants, which enhance both immune maturation and asthma development. Characterization of underlying fever-associated transcriptomic profiles may unm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb704b96d3bde037dbc641caaa26dc2b
https://pubmed.ncbi.nlm.nih.gov/30217468
https://pubmed.ncbi.nlm.nih.gov/30217468
Autor:
Patrick G. Holt, Danny Mok, Andrew Bakshi, Shu Mei Teo, Barbara J. Holt, Qin Qin Huang, Kathryn E. Holt, Artika P. Nath, Agus Salim, Howard H.F. Tang, Michael Inouye, Chiea Chuen Khor, Scott C. Ritchie, Marta Brozynska, Peter D. Sly
Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we collected cord blood samples from a birth cohort and mapped expression quantitative trait
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c27b011880e32395a3d68176ac62f9
https://www.repository.cam.ac.uk/handle/1810/306706
https://www.repository.cam.ac.uk/handle/1810/306706
Autor:
Anthony Bosco, Niamh M. Troy, Barbara J. Holt, Anya C. Jones, Patrick G. Holt, Rochelle Hartmann, Denise Anderson, Michael Serralha, Dominic Mallon
BackgroundMultiple regulatory mechanisms have been identified employing conventional hypothesis-driven approaches as contributing to allergen-specific immunotherapy outcomes, but understanding of how these integrate to maintain immunological homeosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac2429ae0b2ce5b3be78ed42a937d88
https://doi.org/10.1101/473561
https://doi.org/10.1101/473561