Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Barbara J, Klocke"'
Autor:
Rachel Q Muir, Barbara J Klocke, Melissa S Jennings, Patrick A Molina, Jung-Shan Hsu, Cailin E Kellum, Katie L Alexander, Goo Lee, Jeremy B Foote, Robin G Lorenz, Jennifer S Pollock, Craig L Maynard
Publikováno v:
Inflammatory Bowel Diseases. 29:960-972
Background Early life stress (ELS) is an environmental trigger believed to promote increased risk of IBD. Our goal was to identify mechanisms whereby ELS in mice affects susceptibility to and/or severity of gut inflammation. Methods We utilized 2 pub
Autor:
Rachel Quinn Muir, Barbara J. Klocke, Kasi C. McPherson, Jeremy B. Foote, Jennifer S. Pollock, Craig L. Maynard
Publikováno v:
Journal of Clinical and Translational Science, Vol 4, Pp 6-7 (2020)
OBJECTIVES/GOALS: The overall goal of this study was to determine the effect of early life stress (ELS) on the intestinal CD4+ T cell immune compartment, at homeostasis and after induction of experimental Inflammatory Bowel Disease (IBD). METHODS/STU
Externí odkaz:
https://doaj.org/article/613a920f56174a28909c3c7dfd0ab03a
Autor:
Niroop Kaza, Latika Kohli, Christopher D Graham, Barbara J Klocke, Steven L Carroll, Kevin A Roth
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0137153 (2015)
Externí odkaz:
https://doaj.org/article/433afc76901841e69b1365926934b5be
Autor:
Chainllie Young, Kevin A. Roth, Barbara J. Klocke, Tim West, David M. Holtzman, Joann Labruyere, Yue-Qin Qin, Krikor Dikranian, John W. Olney
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 608-614 (2005)
Acute, transient exposure to ethanol causes a widespread pattern of caspase-3 activation and neuroapoptosis in the developing rodent brain. To determine whether caspase-3 activation is an essential step in ethanol-induced developmental neuroapoptosis
Externí odkaz:
https://doaj.org/article/ddbf78aae8964682938b87f19d085287
Publikováno v:
The Journal of Immunology. 202:1039-1044
The ICOS pathway has been implicated in the development and functions of regulatory T (Treg) cells, including those producing IL-10. Treg cell–derived IL-10 is indispensable for the establishment and maintenance of intestinal immune homeostasis. We
BNIP3 regulates AT101 [(-)-gossypol] induced death in malignant peripheral nerve sheath tumor cells.
Autor:
Niroop Kaza, Latika Kohli, Christopher D Graham, Barbara J Klocke, Steven L Carroll, Kevin A Roth
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96733 (2014)
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive Schwann cell-derived sarcomas and are the leading cause of mortality in patients with neurofibromatosis type 1 (NF1). Current treatment modalities have been largely ineffective, resulti
Externí odkaz:
https://doaj.org/article/e19a3ee33bf741ecabf4acc854b34604
Autor:
Melissa S Jennings, Barbara J. Klocke, Keri M. Kemp, Hubert M. Tse, L.W. Duck, Craig L. Maynard, Casey D. Morrow, Charles O. Elson, Rachel Q Muir, Goo Lee, Ashley E. Landuyt, Samuel I. Blum
Publikováno v:
Proc Natl Acad Sci U S A
Genome-wide association studies have identified ICOSLG, which encodes the inducible costimulator ligand (ICOSLG or ICOSL) as a susceptibility locus for inflammatory bowel disease. ICOSL has been implicated in the enhancement of pattern recognition re
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39586 (2012)
Endoplasmic reticulum (ER) stress-induced apoptosis has been implicated in various neurodegenerative diseases including Parkinson Disease, Alzheimer Disease and Huntington Disease. PUMA (p53 upregulated modulator of apoptosis) and BIM (BCL2 interacti
Externí odkaz:
https://doaj.org/article/d895311440ae4735a8aee2498efcbeee
Autor:
Rachel Quinn Muir, Barbara J. Klocke, Jeremy B. Foote, Patrick A. Molina, Jennifer S. Pollock, Craig L. Maynard
Publikováno v:
The Journal of Immunology. 206:17.27-17.27
Inflammatory bowel diseases (IBD) are chronic disorders of the gastrointestinal tract with peak onset during adolescence. The etiology of IBD remains poorly understood, but is believed to involve genetic susceptibility, improper immune regulation, an
Autor:
Craig L. Maynard, Rachel Q Muir, Jeremy B. Foote, Barbara J. Klocke, Jennifer S. Pollock, Kasi C McPherson
Publikováno v:
Journal of Clinical and Translational Science. 4:6-7
OBJECTIVES/GOALS: The overall goal of this study was to determine the effect of early life stress (ELS) on the intestinal CD4+ T cell immune compartment, at homeostasis and after induction of experimental Inflammatory Bowel Disease (IBD). METHODS/STU