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of 5
pro vyhledávání: '"Barbara Herlah"'
Autor:
Barbara Herlah, Tjaša Goričan, Nika Strašek Benedik, Simona Golič Grdadolnik, Izidor Sosič, Andrej Perdih
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2995-3018 (2024)
The 4,6-substituted-1,3,5-triazin-2(1H)-ones are promising inhibitors of human DNA topoisomerase IIα. To further develop this chemical class targeting the enzyme´s ATP binding site, the triazin-2(1H)-one substitution position 6 was optimized. Inspi
Externí odkaz:
https://doaj.org/article/a2d96ff88e0843fbb8c7a452b3c05308
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3746-3759 (2023)
Type IIA DNA topoisomerases are complex molecular nanomachines that manage topological states of the DNA molecule in the cell and play a crucial role in cellular processes such as cell division and transcription. They are also established targets of
Externí odkaz:
https://doaj.org/article/af5922e15c6647aaaaf88d94212b6d0a
Autor:
Ilija N. Cvijetić, Barbara Herlah, Aleksandar Marinković, Andrej Perdih, Snežana K. Bjelogrlić
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 341 (2023)
Phenotypic screening of α-substituted thiocarbohydrazones revealed promising activity of 1,5-bis(salicylidene)thiocarbohydrazide against leukemia and breast cancer cells. Supplementary cell-based studies indicated an impairment of DNA replication vi
Externí odkaz:
https://doaj.org/article/8a66374578094fb08789d63c0bae1edf
Autor:
Barbara Herlah, Andrej Hoivik, Luka Jamšek, Katja Valjavec, Norio Yamamoto, Tyuji Hoshino, Krištof Kranjc, Andrej Perdih
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 539 (2022)
The emergence of SARS-CoV-2, responsible for the global COVID-19 pandemic, requires the rapid development of novel antiviral drugs that would contribute to an effective treatment alongside vaccines. Drug repurposing and development of new molecules t
Externí odkaz:
https://doaj.org/article/8d0e56a5c12d46d488d1637e278c88c0
Autor:
Maša, Kenda, Jan, Vegelj, Barbara, Herlah, Andrej, Perdih, Přemysl, Mladěnka, Marija, Sollner Dolenc
Publikováno v:
International Journal of Molecular Sciences
Firefly luciferase is susceptible to inhibition and stabilization by compounds under investigation for biological activity and toxicity. This can lead to false-positive results in in vitro cell-based assays. However, firefly luciferase remains one of