Harmonization of description and classification of fetal observations: Achievements and problems still unresolved

Autor: Wolfgang Lingk, Ali S. Faqi, Kohei Shiota, Steffen Schneider, Elkiane Macedo Rama, Sabine Kudicke, Roland Solecki, Ralph Gerspach, Mariska Tegelenbosch, Stephane Barbellion, Susan L. Makris, Heinrich Bürgin, Francisco José Roma Paumgartten, Ulrich Hübel, Samia Khalil, Helen Håkansson, Eva Tamborini, Ruth Clark, David Wise, Jochen Buschmann, Thomas B. Knudsen, Laura Comotto, Brigitte Bergmann, Barbara Heinrich-Hirsch, Konstanze Grote, Beate Ulbrich, Thelma Helena Inazaki, Verena Heinrich, Thomas Hofmann, Simone Müller, E.A.J. van Duijnhoven, Ibrahim Chahoud, Rudolf Pfeil, Antje Fuchs

Publikováno v: Reproductive Toxicology. 35:48-55

This article summarizes the 7th Workshop on the Terminology in Developmental Toxicology held in Berlin, May 4-6, 2011. The series of Berlin Workshops has been mainly concerned with the harmonization of terminology and classification of fetal anomalie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4beb7d4d921761fcd2ed182778e048f0
https://doi.org/10.1016/j.reprotox.2012.06.006

Harmonization of rat fetal external and visceral terminology and classification Report of the Fourth Workshop on the Terminology in Developmental Toxicology, Berlin, 18–20 April 2002

Autor: Francisco José Roma Paumgartten, Elke Röhrdanz, Ulrich Hübel, Sabine Kudicke, James Edwards, Brigitte Bergmann, Palmira Hakaite, Jennifer Seed, Jürgen Hellwig, Ana maria Klaus, Brigitte Woelffel, Heinrich Bürgin, Tim Meredith, Carolyn Vickers, E.A.J. van Duijnhoven, Martina Rauch-Ernst, Simone Müller, Ibrahim Chahoud, Martine Duverger, Mary Moxon, Samia Khalil, Alice Druga, Wolfgang Lingk, Roland Solecki, Thomas Hofmann, Barbara Heinrich-Hirsch, Rudolf Pfeil, François Spézia, Pierre Guittin, Hannelore Freudenberger, Ruth Clark, Jochen Buschmann, Martin Paul

Publikováno v: Reproductive Toxicology. 17:625-637

This article is a report on the Fourth Berlin Workshop on Terminology in Developmental Toxicology, which was held in April 2002. The workshop is part of an international project in the field of harmonization of terminology in developmental toxicology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d02d4278b93ad3424d05b727cffd0ad6
https://doi.org/10.1016/s0890-6238(03)00092-3

Immunochemical analysis of Cytochrome P450 variability in human leukapheresed samples and its consequences for the risk assessment process

Autor: Barbara Heinrich-Hirsch, Ulrike Bernauer, Ursula Gundert-Remy, Henrik Garritsen

Publikováno v: Regulatory Toxicology and Pharmacology. 37:318-327

Xenobiotic metabolizing cytochrome P450 (P450) enzymes were investigated in leukapheresed samples from 50 human individuals. It was the aim of the study (a). to get insight into the extent of extrahepatic P450 variability, (b). to investigate whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94eb6ee32cd6775fb2d8f59ef0b2e177
https://doi.org/10.1016/s0273-2300(03)00012-6

On the impact of second generation mating and offspring in multi-generation reproductive toxicity studies on classification and labelling of substances in Europe

Autor: Erna Schenk, Martin Paparella, Ulla Hass, Manon Beekhuijzen, Barbara Heinrich-Hirsch, Beate Ulbrich, Aldert H. Piersma, Emiel Rorije, Andre Muller, Betty C. Hakkert

Publikováno v: Rorije, E, Muller, A, Beekhuijzen, M E W, Hass, U, Heinrich-Hirsch, B, Paparella, M, Schenk, E, Ulbrich, B, Hakkert, B C & Piersma, A H 2011, ' On the impact of second generation mating and offspring in multi-generation reproductive toxicity studies on classification and labelling of substances in Europe ', Regulatory Toxicology and Pharmacology, vol. 61, no. 2, pp. 251-260 . https://doi.org/10.1016/j.yrtph.2011.08.005

The possible impact on classification and labelling decisions of effects observed in second generation parental (P1) and offspring (F2) parameters in multi-generation studies was investigated. This was done for 50 substances classified as reproductiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abed105da56e69fc9f8ef5f1f7f36cf4
https://orbit.dtu.dk/en/publications/b1dddd5f-ff06-4dde-b8e5-6bf3dd92bcba

Genetically engineered V79 Chinese hamster cells for stable expression of human cytochrome P450IA2

Autor: Friedrich J. Wiebel, Felix Wächter, Thomas Schulz-Schalge, U. Ramp, Frank J. Gonzalez, Albrecht Seidel, Helmut Greim, Barbara Heinrich-Hirsch, Catherine Wölfel, Johannes Doehmer, Heinz Frank

Publikováno v: European Journal of Pharmacology: Environmental Toxicology and Pharmacology. 228:95-102

V79 Chinese hamster cells were genetically engineered for stable expression of human P450IA2. Full length cDNA, encoding human P450IA2, was inserted into an SV40 early promoter containing eukaryotic expression vector and cointroduced with the selecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce0753280867152c4718129c88d0189
https://doi.org/10.1016/0926-6917(92)90017-7