CBA (4-chloro-2-(2-chlorophenoxy)acetamido) benzoic acid) inhibits TMEM206 mediated currents and TMEM206 does not contribute to acid-induced cell death in colorectal cancer cells

Autor: Sven Kappel, Korollus Melek, Daniela Ross-Kaschitza, Barbara Hauert, Christian E. Gerber, Martin Lochner, Christine Peinelt

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

Introduction: Upon activation at low pH, TMEM206 conducts Cl− ions across plasma and vesicular membranes. In a (patho)physiological context, TMEM206 was reported to contribute to acid-induced cell death in neurons, kidney and cervical epithelial ce

Externí odkaz: https://doaj.org/article/503c6247f68848779b4f4a3c5e221059

Culling Less Fit Neurons Protects against Amyloid-β-Induced Brain Damage and Cognitive and Motor Decline

Autor: Dina S. Coelho, Silvia Schwartz, Marisa M. Merino, Barbara Hauert, Barbara Topfel, Colin Tieche, Christa Rhiner, Eduardo Moreno

Publikováno v: Cell Reports, Vol 25, Iss 13, Pp 3661-3673.e3 (2018)

Summary: Alzheimer’s disease (AD) is the most common form of dementia, impairing cognitive and motor functions. One of the pathological hallmarks of AD is neuronal loss, which is not reflected in mouse models of AD. Therefore, the role of neuronal

Externí odkaz: https://doaj.org/article/b10a33798f2f4a09a09739163318337c

p53 alters intracellular Ca

Autor: Sven, Kappel, Daniela, Ross-Kaschitza, Barbara, Hauert, Karen, Rother, Christine, Peinelt

Publikováno v: Cell calcium. 104

Altered expression of transient receptor potential channel melastatin 4 (TRPM4) contributes to several diseases, including cardiac conduction disorders, immune diseases, and cancer. Yet the underlying mechanisms of TRPM4 expression changes remain elu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3cd5faded9393dd15b5dc3bf3cb18510
https://pubmed.ncbi.nlm.nih.gov/35500522

Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions

Autor: Anna Borgström, Martin Spahn, Sven Kappel, Paulina Stokłosa, Roland Baur, Christine Peinelt, Barbara Hauert, Eugenio Zoni, Marianna Kruithof-de Julio, Mirjam Kiener

Publikováno v: Borgström, Anna; Hauert, Barbara; Kappel, Sven; Zoni, Eugenio; Kiener, Mirjam; Stokłosa, Paulina; Baur, Roland; Spahn, Martin; Kruithof-de Julio, Marianna; Peinelt, Christine (2021). Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions. Journal of molecular biology, 433(17), p. 166665. Elsevier 10.1016/j.jmb.2020.09.024

Transient receptor potential melastatin 4 (TRPM4) is a broadly expressed Ca2+ activated monovalent cation channel that contributes to the pathophysiology of several diseases. For this study, we generated stable CRISPR/Cas9 TRPM4 knockout (K.O.) cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dbde43acb4b661d45aa024914c53295
https://doi.org/10.1016/j.jmb.2020.09.024

Culling Less Fit Neurons Protects against Amyloid-β-Induced Brain Damage and Cognitive and Motor Decline

Autor: Christa Rhiner, Marisa M. Merino, Colin Tièche, Silvia Schwartz, Barbara Hauert, Dina S. Coelho, Eduardo Moreno, Barbara Topfel

Publikováno v: Cell Reports
Cell Reports, Vol 25, Iss 13, Pp 3661-3673.e3 (2018)

Summary Alzheimer’s disease (AD) is the most common form of dementia, impairing cognitive and motor functions. One of the pathological hallmarks of AD is neuronal loss, which is not reflected in mouse models of AD. Therefore, the role of neuronal d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50047fee04c3228005d67ba6d79fed7e
https://pubmed.ncbi.nlm.nih.gov/30590040