Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Barbara Hanney"'
Autor:
John A. Morrow, Robert Mazzola, Cristian Salinas, Eric D. Hostetler, Stefania Risso, Fiona Thomson, Tjerk Bueters, Nicholas B. Hastings, Jenny Wai, Sony Agrawal, Liza Gantert, Brian C. Magliaro, Paul McQuade, Zhizhen Zeng, Marie A. Holahan, David Hesk, Melissa Egbertson, Jeffrey W. Schubert, Ling Tong, Robert Gomez, Jongrock Kong, Aniket Joshi, Frederick J. Monsma, David M. Tellers, Kristen L.G. Jones, Jason M. Uslaner, Jing Liao, Patricia Miller, Michelle Smith, Oleg Selyutin, Kerry Riffel, Xiaolei Gao, Scott T. Harrison, Zhaoyang Meng, James Mulhearn, Michael Man-Chu Lo, Wenping Li, Michael T. Rudd, Barbara Hanney, Mona Purcell, Jianming Bao, Hyking Haley
Publikováno v:
Journal of Medicinal Chemistry. 63:2411-2425
The measurement of receptor occupancy (RO) using positron emission tomography (PET) has been instrumental in guiding discovery and development of CNS directed therapeutics. We and others have investigated muscarinic acetylcholine receptor 4 (M4) posi
Autor:
Sarah L Huszar Agrapides, Susan E. Browne, Jeffrey W. Schubert, Jaime Lynn Bunda, Robert Gomez, Tynebor Robert M, John M. Sanders, Melissa Egbertson, Kristen L.G. Jones, Jason M. Uslaner, Natasa Pajkovic, James Mulhearn, Anthony L. Gotter, Christopher D. Cox, Brian C. Magliaro, Barbara Hanney, Jenny Wai, Julie A. O'Brien, Scott T. Harrison, Stefania Risso, Anne Marie Taylor, John A. Mccauley, Sean M. Smith
Publikováno v:
ChemMedChem. 14:943-951
Herein we describe the discovery and optimization of a new series of 2,3-disubstituted and 2,3,6-trisubstituted muscarinic acetylcholine receptor 4 (M4 ) positive allosteric modulators (PAMs). Iterative libraries enabled rapid exploration of one-dime
Autor:
Ling, Tong, Wenping, Li, Michael Man-Chu, Lo, Xiaolei, Gao, Jenny Miu-Chen, Wai, Michael, Rudd, David, Tellers, Aniket, Joshi, Zhizhen, Zeng, Patricia, Miller, Cristian, Salinas, Kerry, Riffel, Hyking, Haley, Mona, Purcell, Marie, Holahan, Liza, Gantert, Jeffrey W, Schubert, Kristen, Jones, James, Mulhearn, Melissa, Egbertson, Zhaoyang, Meng, Barbara, Hanney, Robert, Gomez, Scott T, Harrison, Paul, McQuade, Tjerk, Bueters, Jason, Uslaner, John, Morrow, Fiona, Thomson, Jongrock, Kong, Jing, Liao, Oleg, Selyutin, Jianming, Bao, Nicholas B, Hastings, Sony, Agrawal, Brian C, Magliaro, Frederick J, Monsma, Michelle D, Smith, Stefania, Risso, David, Hesk, Eric, Hostetler, Robert, Mazzola
Publikováno v:
Journal of medicinal chemistry. 63(5)
The measurement of receptor occupancy (RO) using positron emission tomography (PET) has been instrumental in guiding discovery and development of CNS directed therapeutics. We and others have investigated muscarinic acetylcholine receptor 4 (M4) posi
Autor:
Jeffrey W, Schubert, Scott T, Harrison, James, Mulhearn, Robert, Gomez, Robert, Tynebor, Kristen, Jones, Jaime, Bunda, Barbara, Hanney, Jenny Miu-Chen, Wai, Chris, Cox, John A, McCauley, John M, Sanders, Brian, Magliaro, Julie, O'Brien, Natasa, Pajkovic, Sarah L, Huszar Agrapides, Anne, Taylor, Anthony, Gotter, Sean M, Smith, Jason, Uslaner, Susan, Browne, Stefania, Risso, Melissa, Egbertson
Publikováno v:
ChemMedChem. 14(9)
Herein we describe the discovery and optimization of a new series of 2,3-disubstituted and 2,3,6-trisubstituted muscarinic acetylcholine receptor 4 (M
Autor:
Keith Lee Spencer, Barbara Hanney, Eileen S. Walsh, George D. Hartman, Stephen C. Beck, Carolyn A. Buser, Weikang Tao, Robert B. Lobell, Youwei Yan, Lawrence C. Kuo, Kenneth L. Arrington, Edward J. Brnardic, Mari Ikuta, Sanjeev Munshi, Mark E. Fraley, Constantine Kreatsoulas, Justin T. Steen, Bob Drakas, Laura Sepp-Lorenzino, Kelly Hamilton, Yuntae Kim, Xianzhi Mao, James Hardwick, Steven M. Stirdivant, Keith W. Rickert
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:6049-6053
The development of 3-(indol-2-yl)indazoles as inhibitors of Chek1 kinase is described. Introduction of amides and heteroaryl groups at the C6 position of the indazole ring system provided sufficient Chek1 potency and selectivity over Cdk7 to permit e
Autor:
Keith W. Rickert, Ming-Tain Lai, Daniel Riley, Melissa S. Egbertson, Mike T. Rudd, Kausik K. Nanda, Barbara Hanney, Shawn J. Stachel, Stephanie A. Kane, Jay A. Grobler, Ahren Iver Green, John M. Sanders, Christopher Daley, Paul Zuck, Vandna Munshi, Edward J. Brnardic, Kristen G. Jones, Darrell A. Henze, Alicja Krasowska-Zoladek, Hua-Poo Su, Mark T. Bilodeau, Yiwei Li, Dennis Murphy, Michael D. Leitl, Peter J. Manley
Publikováno v:
Journal of medicinal chemistry. 57(13)
We have identified several series of small molecule inhibitors of TrkA with unique binding modes. The starting leads were chosen to maximize the structural and binding mode diversity derived from a high throughput screen of our internal compound coll
Autor:
Karen Brown, Barbara Hanney, Myers Michael, Valeria Chu, Spada Alfred P, Wei He, Dennis J Colussi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1737-1739
Nonbenzamidine compounds (imidazole, pyridine, pyrimidine, and thiazole derivatives) as selective serine protease factor Xa inhibitors are discussed.
Autor:
Zaid Jayyosi, Ken Page, Glenda Bilder, Saul Needle, Wei He, Dilip Amin, Barbara Hanney, Myers Michael, Mark H. Perrone, Spada Alfred P, Helen Galzcinski
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(18)
RPR127963 demonstrates an excellent pharmacokinetic profile in several species and was found to be efficacious in the prevention of restenosis in a Yucatan mini-pig model upon oral administration of 1-5 mg/kg. The in vitro selectivity profile and SAR
Autor:
Glenda Bilder, Natalie Setzer, Barbara Hanney, Helen Galzcinski, Myers Michael, Spada Alfred P, Saul Needle, Dilip Amin, Wei He, Martin P. Maguire, Allison L Zulli
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(18)
Novel substituted 2-anilino- and 2-cycloalkylaminoquinoxalines have been found to be useful and selective inhibitors of PDGF-R autophosphorylation. Replacement of an anilino-substituent with substituted cyclohexylamino- or norbornylamino substituents
Autor:
Spada Alfred P, Wei He, Stephen M. Condon, Dennis Colussi, Myers Michael R, Christopher J. Burns, Karen Brown, Michael R. Becker, Barbara Hanney, Valeria Chu
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(6)
Benzimidazoles and their isosteric compounds as factor Xa inhibitors are discussed