Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Barbara Grunwald"'
Autor:
Joan Miguel Romero, Emma Titmuss, Yifan Wang, James Vafiadis, Alain Pacis, Gun Ho Jang, Amy Zhang, Bryn Golesworthy, Tatiana Lenko, Laura Williamson, Barbara Grunwald, Grainne M. O'Kane, Julie Wilson, Steven Gallinger, Janessa J. Laskin, George Zogopoulos
Publikováno v:
Journal of Clinical Oncology. 40:2558-2558
2558 Background: Immune checkpoint inhibitors (ICI) are highly effective in select cancers. Novel predictors of T cell-inflammation may identify a broader subset of tumors with ICI responsiveness. Our group has identified four chemokines (CCL4, CCL5,
Autor:
Joan Miguel Romero, Emma Titmuss, Yifan Wang, James Vafiadis, Alain Pacis, Gun Ho Jang, Amy Zhang, Bryn Golesworthy, Tatiana Lenko, Laura M. Williamson, Barbara Grünwald, Grainne M. O’Kane, Steven J. M. Jones, Marco. A. Marra, Julie M. Wilson, Steven Gallinger, Janessa Laskin, George Zogopoulos
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-14 (2023)
Abstract Immune checkpoint inhibitors (ICI) are highly effective in specific cancers where canonical markers of antitumor immunity are used for patient selection. Improved predictors of T cell-inflammation are needed to identify ICI-responsive tumor
Externí odkaz:
https://doaj.org/article/8dd7df9c6c22430ba3c3588f08acd012
Autor:
Yifan Wang, Robert E. Denroche, Alain Pacis, Joan Miguel Romero, Gun Ho Jang, Steven Gallinger, Barbara Grunwald, George Zogopoulos
Publikováno v:
Journal of Clinical Oncology. 39:2546-2546
2546 Background: Treatment responses to immune checkpoint blockade (ICB) associate with T cell tumor inflammation. Tumors with mismatch repair deficiency display an inflammatory tumor phenotype and respond to ICB. Similarly, tumors with homologous re
Autor:
Robert E. Denroche, Barbara Grunwald, Amy Zhang, Sandra Fischer, Robert C. Grant, Anna Dodd, Rebecca M. Prince, Elena Elimova, Grainne M. O'Kane, Julie M. Wilson, Gun Ho Jang, George Zogopoulos, Sarah Louise Picardo, Steven Gallinger, Faiyaz Notta, Jennifer J. Knox, Shari Moura
Publikováno v:
Journal of Clinical Oncology. 38:747-747
747 Background: It is unclear whether locally advanced pancreatic cancer (LAPC) should be treated similarly to metastatic pancreatic cancer (MPC). Clinical trials often exclude LAPC. We compare clinical and genomic characteristics of LAPC and MPC. Me
Autor:
Gun Ho Jang, Rob Denroche, Rebecca M. Prince, Faiyaz Notta, Grainne M. O'Kane, George Zogopoulos, Steven Gallinger, Sandra Fischer, Elena Elimova, Jennifer J. Knox, Robert C. Grant, Anna Dodd, Shari Moura, Barbara Grunwald, Amy Zhang, Julie M. Wilson, Mehdi M Masoomian
Publikováno v:
Journal of Clinical Oncology. 37:188-188
188 Background: Predictive mutational and transcriptional features in advanced PDAC are needed for improved patient stratification and treatment selection. Methods: Patients (pts) on the COMPASS trial with advanced PDAC are prospectively recruited pr
Autor:
Olga Prokopchuk, Barbara Grünwald, Ulrich Nitsche, Carsten Jäger, Oleksii L. Prokopchuk, Elaine C. Schubert, Helmut Friess, Marc E. Martignoni, Achim Krüger
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a candidate diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma (PDAC). Here, we determined the possible association of systemic TIMP-1 levels with cachexia
Externí odkaz:
https://doaj.org/article/908f03a8ba5449ae88b0604c98964470
Publikováno v:
Haematologica, Vol 100, Iss 8 (2015)
The homeostasis of neutrophil granulocytes can affect the outcome of several inflammation-associated diseases including cancer. The regulation of this homeostasis is still not completely understood. We previously found that elevated systemic levels o
Externí odkaz:
https://doaj.org/article/f5278fad543044a19d3d77601d10fc21