Candidate Single Nucleotide Polymorphism Markers for Arsenic Responsiveness of Protein Targets

Autor: Barbara Graham-Evans, Paul B. Tchounwou, Udensi K. Udensi, Hari H. P. Cohly, Matthew N. Anyanwu, Raphael D. Isokpehi, Rajendram V. Rajnarayanan

Publikováno v: Bioinformatics and Biology Insights
Bioinformatics and Biology Insights, Vol 2010, Iss 4, Pp 99-111 (2010)
Bioinformatics and Biology Insights, Vol 4 (2010)

Arsenic is a toxic metalloid that causes skin cancer and binds to cysteine residues—a property that could be used to infer arsenic responsiveness of a target protein. Non-synonymous Single Nucleotide Polymorphisms (nsSNPs) result in amino acid subs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c3af16fe0713be5c074299396df0d0
http://europepmc.org/articles/PMC2964045

Enhanced Green Fluorescent Protein Is a Nearly Ideal Long-Term Expression Tracer for Hematopoietic Stem Cells, Whereas DsRed-Express Fluorescent Protein Is Not

Autor: Hal E. Broxmeyer, Jing Yao, Barbara Graham Evans, Wen Tao, Giao Hangoc, Christopher B. Ballas, Kenneth Cornetta, Scott Cooper

Publikováno v: Stem Cells. 25:670-678

Validated gene transfer and expression tracers are essential for elucidating functions of mammalian genes. Here, we have determined the suitability and unintended side effects of enhanced green fluorescent protein (EGFP) and DsRed-Express fluorescent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d878289d31ab429d934b57016d48be4
https://doi.org/10.1634/stemcells.2006-0553

Cytotoxic Effect of Arsenic Trioxide in Adenocarcinoma Colorectal Cancer (HT-29) Cells

Autor: Jacqueline J, Stevens, Barbara, Graham-Evans, Alice M, Walker, Brinda, Armstead, Paul B, Tchounwou

Publikováno v: Metal ions in biology and medicine : proceedings of the ... International Symposium on Metal Ions in Biology and Medicine held ... = Les ions metalliques en biologie et en medecine : ... Symposium international sur les ions metalliques .... 10

Arsenic is a heavy metal that exhibits a high degree of toxicity to various organ systems. In humans, this compound is associated with an increase risk of skin cancer, and may cause cancers of the lung, liver, bladder, kidney, and colon. The mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::08fed885f7fba70c55e79aeba92e947a
https://pubmed.ncbi.nlm.nih.gov/21603592

TGF-beta combined with M-CSF and IL-4 induces generation of immune inhibitory cord blood dendritic cells capable of enhancing cytokine-induced ex vivo expansion of myeloid progenitors

Autor: Scott Cooper, Saeid Abediankenari, Young-June Kim, Hal E. Broxmeyer, Shigeki Ito, Barbara Graham-Evans, Timothy B. Campbell, Geling Li

Publikováno v: Blood. 110(8)

Tolerogenic dendritic cells (DCs) may be valuable in transplantation for silencing immune reaction. Macrophage colony-stimulating factor (M-CSF)/IL-4 induces differentiation of cord blood (CB) monocytes into DCs (M-DCs) with tolerogenic phenotype/fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232319a97980b6055fc3c24a4684b017
https://pubmed.ncbi.nlm.nih.gov/17585053

Arsenic-induced genotoxic and cytotoxic effects in human keratinocytes, melanocytes and dendritic cells

Autor: Hongtao Yu, Paul B. Tchounwou, Barbara Graham-Evans, Hari H. P. Cohly

Publikováno v: International Journal of Environmental Research and Public Health; Volume 1; Issue 2; Pages: 83-89
International Journal of Environmental Research and Public Health, Vol 1, Iss 2, Pp 83-89 (2004)

Arsenical keratosis and skin cancer are among the most common health effects associated with acute and chronic exposures to arsenic. This study examines the acute and chronic dose-responses of arsenic in established human cell lines using keratinocyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982398b421b4345ba811105d22e1541f
https://pubmed.ncbi.nlm.nih.gov/16696182