Výsledky vyhledávání - "Barbara Gorgoni"

Akademický článek

Destabilization of Eukaryote mRNAs by 5′ Proximal Stop Codons Can Occur Independently of the Nonsense-Mediated mRNA Decay Pathway

Autor: Barbara Gorgoni, Yun-Bo Zhao, J. Krishnan, Ian Stansfield

Publikováno v: Cells, Vol 8, Iss 8, p 800 (2019)

In eukaryotes, the binding of poly(A) binding protein (PAB) to the poly(A) tail is central to maintaining mRNA stability. PABP interacts with the translation termination apparatus, and with eIF4G to maintain 3′−5′ mRNA interactions as part of a

Externí odkaz: https://doaj.org/article/968435b3274d4d498f77c19ebaf7f724

Zobrazit plný text záznamu

Plný text ve formátu HTML

DAZL regulates mRNA deadenylation independently of translation in germ cells

Autor: William A. Richardson, Zoe C. Johnston, Richard W.P. Smith, Ross C. Anderson, Barbara Gorgoni, Nicola K. Gray, Grieve Km

Aberrant gene expression during gametogenesis is one of the factors underlying infertility, which affects roughly 15% of couples worldwide.Deleted-in-Azoospermia-Like (DAZL),a member of theDAZ-genefamily, encodes an mRNA-specific regulator of transla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8c30a154e6dd2c7f8fc4ee4ffb42e3e
https://doi.org/10.1101/2021.02.02.429436

Zobrazit plný text záznamu

Viral and cellular mRNA-specific activators harness PABP and eIF4G to promote translation initiation downstream of cap binding

Autor: Poonam Malik, Osmany Larralde, Joel W.S. Smith, Ross C. Anderson, Sheila V. Graham, Barbara Gorgoni, Nicola K. Gray, Richard P. Smith, William A. Richardson

Publikováno v: Smith, R W P, Anderson, R C, Larralde, O, Smith, J W S, Gorgoni, B, Richardson, W A, Malik, P, Graham, S V & Gray, N K 2017, ' Viral and cellular mRNA-specific activators harness PABP and eIF4G to promote translation initiation downstream of cap binding ', Proceedings of the National Academy of Sciences, vol. 114, no. 24, pp. 6310-6315 . https://doi.org/10.1073/pnas.1610417114

Regulation of mRNA translation is a major control point for gene expression and is critical for life. Of central importance is the complex between cap-bound eukaryotic initiation factor 4E (eIF4E), eIF4G, and poly(A) tail-binding protein (PABP) that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7d4e62d1c83c13f1961b24778ca517
https://hdl.handle.net/20.500.11820/0fe702da-1199-4ad4-8160-e07255230b49

Zobrazit plný text záznamu

Poly(A)-binding proteins are functionally distinct and have essential roles during vertebrate development

Autor: Philippe Gautier, Hannah M. Burgess, Michael D. Sheets, Barbara Gorgoni, Gavin S. Wilkie, Ross C. Anderson, Matthew Brook, Joao P. Sousa Martins, Nicola K. Gray, William A. Richardson

Publikováno v: Gorgoni, B, Richardson, W A, Burgess, H M, Anderson, R C, Wilkie, G S, Gautier, P, Martins, J P S, Brook, M, Sheets, M D & Gray, N K 2011, ' Poly(A)-binding proteins are functionally distinct and have essential roles during vertebrate development ', Proceedings of the National Academy of Sciences, vol. 108, no. 19, pp. 7844-7849 . https://doi.org/10.1073/pnas.1017664108

Translational control of many mRNAs in developing metazoan embryos is achieved by alterations in their poly(A) tail length. A family of cytoplasmic poly(A)-binding proteins (PABPs) bind the poly(A) tail and can regulate mRNA translation and stability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c99e62c9979372edc46a003ff92fd6
https://doi.org/10.1073/pnas.1017664108

Zobrazit plný text záznamu

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

Publikováno v: Nature Genetics. 40:437-442

Uric acid is the end product of purine metabolism in humans and great apes, which have lost hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200-500 microM) compared with other mammals (3-120 microM). About 70% of da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcdc9418730732dfbc0865ab2599cc65
https://doi.org/10.1038/ng.106

Zobrazit plný text záznamu

The stem–loop binding protein stimulates histone translation at an early step in the initiation pathway

Autor: Daniel Schümperli, Berndt Müller, Barbara Gorgoni, Stuart Andrews, André Schaller, Nicola K. Gray

Publikováno v: Gorgoni, B, Andrews, S, Schaller, A, Schümperli, D, Gray, N K & Müller, B 2005, ' The stem-loop binding protein stimulates histone translation at an early step in the initiation pathway ', RNA, vol. 11, no. 7, pp. 1030-42 . https://doi.org/10.1261/rna.7281305

Metazoan replication-dependent histone mRNAs do not have a poly(A) tail but end instead in a conserved stem–loop structure. Efficient translation of these mRNAs is dependent on the stem–loop binding protein (SLBP). Here we explore the mechanism b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d246981b600f592ebaffd2ec72e5557e
https://doi.org/10.1261/rna.7281305

Zobrazit plný text záznamu

The roles of cytoplasmic poly(A)-binding proteins in regulating gene expression: A developmental perspective

Autor: Barbara Gorgoni, Nicola K. Gray

Publikováno v: Briefings in Functional Genomics and Proteomics. 3:125-141

Poly(A)-binding proteins (PABPs) are central to the regulation of messenger RNA (mRNA) translation and stability; however, the roles and contributions of different PABP family members in controlling gene expression are not yet fully understood. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0a0a000ed10a38e831f093772e8df6
https://doi.org/10.1093/bfgp/3.2.125

Zobrazit plný text záznamu

Controlling translation elongation efficiency: tRNA regulation of ribosome flux on the mRNA

Autor: Barbara Gorgoni, Matthew R. McFarland, M. Carmen Romano, Elizabeth Marshall, Ian Stansfield

Publikováno v: Biochemical Society transactions. 42(1)

Gene expression can be regulated by a wide variety of mechanisms. One example concerns the growing body of evidence that the protein-production rate can be regulated at the level of translation elongation by controlling ribosome flux across the mRNA.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b0f214fd1052eb8822f90968eaea36
https://pubmed.ncbi.nlm.nih.gov/24450645

Zobrazit plný text záznamu

The Induction of Cyclooxygenase-2 mRNA in Macrophages Is Biphasic and Requires both CCAAT Enhancer-binding protein β (C/EBPβ) and C/EBPδ Transcription Factors

Autor: Valeria Poli, Matilde Caivano, Philip Cohen, Barbara Gorgoni

Publikováno v: Journal of Biological Chemistry. 276:48693-48701

Prostaglandins are important mediators of activated macrophage functions, and their inducible synthesis is mediated by cyclooxygenase-2 (COX-2). Here, we make use of the murine macrophage cells RAW264 as well as of immortalized macrophages derived fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364422d3caede00089bde7225c29762a
https://doi.org/10.1074/jbc.m108282200

Zobrazit plný text záznamu

The Transcription Factor C/EBPβ Is Essential for Inducible Expression of the cox-2 Gene in Macrophages but Not in Fibroblasts

Autor: Barbara Gorgoni, Valeria Poli, Matilde Caivano, Carmen Arizmendi

Publikováno v: Journal of Biological Chemistry. 276:40769-40777

Cyclooxygenase-2 (COX-2) is the rate-limiting enzyme for the inducible synthesis of prostaglandins, and its up-regulated activity is thought to play a pathological role in diseases such as inflammatory bowel disease, rheumatoid arthritis, and cancer.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e02f74f3fb85540d6774ec3c81b7687
https://doi.org/10.1074/jbc.m106865200

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání