Výsledky vyhledávání - "Barbara Golos"

Unusual Developmental Pattern of Expression of Enzymes Involved in DNA Biosynthesis in Trichinella spiralis and Trichinella pseudospiralis

Autor: Elżbieta Jagielska, Elżbieta Wałajtys-Rode, Barbara Golos, Joanna Cieśla, Zbigniew Zieliński, Patrycja Wińska, Wojciech Rode, Magdalena Dąbrowska

Publikováno v: Detection of Bacteria, Viruses, Parasites and Fungi ISBN: 9789048185429

All species in the genus Trichinella, between them T. spiralis and T. pseudospiralis, have been successful in colonizing striated sceletal muscle tissue and remain infective in this niche for months to years. Trichinella spiralis causes trichinellosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d65adeb871db5c33fbe8266481aabc2b
https://doi.org/10.1007/978-90-481-8544-3_14

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Synthesis of 2- or 4-Seleno Analogues of dUMP and FdUMP, and the Corresponding Nucleosides. Interactions with Mammalian Tumour Thymidylate Synthase of the Selenonucleotides and Inhibition of Tumor Cell Growth by the Selenonucleosides

Autor: Katarzyna Wyszynska, Tadeusz Kulikowski, Agnieszka Miazga, Zbigniew Zieliński, Krzysztof Felczak, Barbara Golos, Wojciech Rode, Joanna Ciesla

Publikováno v: Chemistry and Biology of Pteridines and Folates ISBN: 9781461353171

Thymidylate synthase (EC 2.1.1.45), a target enzyme in chemotherapy, catalyzes the N5,10-methylenetetrahydrofolate-dependent C(5) methylation of dUMP. In search of its inhibitors, interactions were compared of new substrate analogues, 4-seleno-dUMP (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41885f0daf8a1c1ace077c09bdf49812
https://doi.org/10.1007/978-1-4615-0945-5_79

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Mechanism of unbalanced growth-induced cell damage. II. A probable relationship between unbalanced growth, DNA breakage and cell death

Autor: Barbara Golos, Janina Malec, Jadwiga Sawecka

Publikováno v: Chemico-biological interactions. 60(1)

This study examines the relationship between unbalanced growth, DNase II activity, DNA breakage and cell survival during the exposure of L5178Y cells to hydroxyurea (HU), excess thymidine (dThR) or HU with excess of four deoxyribonucleosides (dNR). I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e1312fc299afc0f0d781e55731f0de
https://pubmed.ncbi.nlm.nih.gov/3779883

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