Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Barbara G. Molenkamp"'
Autor:
Bas D. Koster, Tamarah D. de Jong, Mari F. C. M. van den Hout, Berbel J. R. Sluijter, Ronald J. C. L. M. Vuylsteke, Barbara G. Molenkamp, Saskia Vosslamber, M. Petrousjka van den Tol, Alfons J. M. van den Eertwegh, Tanja D. de Gruijl
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Whereas TLR9 agonists are recognized as powerful stimulators of antitumor immunity, GM-CSF has had mixed reviews. In previously reported randomized trials we assessed the effects of local immune modulation in early-stage melanoma with CpG-B alone or
Externí odkaz:
https://doaj.org/article/18a66b5567df494eaee6b3d2f17a3993
Autor:
Tanja D. de Gruijl, Rik J. Scheper, Alfons J.M. van den Eertwegh, M. Petrousjka van den Tol, Cornelis L. Verweij, Saskia Vosslamber, Barbara G. Molenkamp, Rieneke van de Ven, Famke L. Schneiders, Paul A.M. van Leeuwen, Bas D. Koster, Mari F.C.M. van den Hout, Berbel J.R. Sluijter
Melanoma-induced suppression of dendritic cells (DC) in the sentinel lymph node (SLN) interferes with the generation of protective antitumor immunity. In an effort to strengthen immune defense against metastatic spread, we performed a three-arm phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e02df92006201a418a037bf490e4be64
https://doi.org/10.1158/2326-6066.c.6548909.v1
https://doi.org/10.1158/2326-6066.c.6548909.v1
Autor:
Tanja D. de Gruijl, M. Petrousjka van den Tol, Paul A.M. van Leeuwen, Rik J. Scheper, Alfons J.M. van den Eertwegh, Rieneke van de Ven, Barbara G. Molenkamp, Berbel J.R. Sluijter, Bas D. Koster, Mari F.C.M. van den Hout
Melanoma exerts immune-suppressive effects to facilitate tumor progression and metastatic spread. We studied these effects on dendritic cell (DC) and T-cell subsets in 36 melanoma sentinel lymph node (SLN) from 28 stage I–III melanoma patients and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::650cc52c1fdb2d4f6f1282e242de79a0
https://doi.org/10.1158/2326-6066.c.6548203.v1
https://doi.org/10.1158/2326-6066.c.6548203.v1
Autor:
Tanja D. de Gruijl, M. Petrousjka van den Tol, Paul A.M. van Leeuwen, Rik J. Scheper, Alfons J.M. van den Eertwegh, Rieneke van de Ven, Barbara G. Molenkamp, Berbel J.R. Sluijter, Bas D. Koster, Mari F.C.M. van den Hout
Differences in SLN-resident DCs between patients with and without distant recurrence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9058c2863eeb09d8a1523481627ee1be
https://doi.org/10.1158/2326-6066.22536670.v1
https://doi.org/10.1158/2326-6066.22536670.v1
Autor:
Tanja D. de Gruijl, M. Petrousjka van den Tol, Paul A.M. van Leeuwen, Rik J. Scheper, Alfons J.M. van den Eertwegh, Rieneke van de Ven, Barbara G. Molenkamp, Berbel J.R. Sluijter, Bas D. Koster, Mari F.C.M. van den Hout
Placebo-administered vs off-trial patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4594d54561af4cd199477457447bf897
https://doi.org/10.1158/2326-6066.22536667.v1
https://doi.org/10.1158/2326-6066.22536667.v1
Autor:
Tanja D. de Gruijl, Rik J. Scheper, Alfons J.M. van den Eertwegh, M. Petrousjka van den Tol, Cornelis L. Verweij, Saskia Vosslamber, Barbara G. Molenkamp, Rieneke van de Ven, Famke L. Schneiders, Paul A.M. van Leeuwen, Bas D. Koster, Mari F.C.M. van den Hout, Berbel J.R. Sluijter
Gating strategies for analysis of A) plasmacytoid DC (pDC) and B) skin-migratory conventional DC (cDC) subsets: Dermal DC (DDC) and Langerhans Cells (LC) and C) LN-resident cDC subsets in melanoma Sentinel Lymph Nodes (SLN).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b1133dd30824703ebb64c6a48f04d5
https://doi.org/10.1158/2326-6066.22538840.v1
https://doi.org/10.1158/2326-6066.22538840.v1
Autor:
Tanja D. de Gruijl, Rik J. Scheper, Alfons J.M. van den Eertwegh, M. Petrousjka van den Tol, Cornelis L. Verweij, Saskia Vosslamber, Barbara G. Molenkamp, Rieneke van de Ven, Famke L. Schneiders, Paul A.M. van Leeuwen, Bas D. Koster, Mari F.C.M. van den Hout, Berbel J.R. Sluijter
Expression of the cross-priming associated markers BDCA3/CD141 and CLEC9A on the four identified cDC subsets in single-cell suspensions of untreated melanoma Sentinel Lymph Nodes SLN (mean {plus minus} SEM of at least three separate experiments are s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e874bd0cb509cc2ee8e787bd684408f
https://doi.org/10.1158/2326-6066.22538837.v1
https://doi.org/10.1158/2326-6066.22538837.v1
Autor:
Tanja D. de Gruijl, Alfons J.M. van den Eertwegh, M. Petrousjka van den Tol, Rik J. Scheper, Paul A.M. van Leeuwen, Arnold Baars, Ronald J.C.L.M. Vuylsteke, Barbara G. Molenkamp, Berbel J.R. Sluijter, Mari F.C.M. van den Hout, Bas D. Koster
Purpose: Although risk of recurrence after surgical removal of clinical stage I–II melanoma is considerable, there is no adjuvant therapy with proven efficacy. Here, we provide clinical evidence that a local conditioning regimen, aimed at immunolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8b65043c1b79d4334b7b0f70fd87a4
https://doi.org/10.1158/1078-0432.c.6526217
https://doi.org/10.1158/1078-0432.c.6526217
Autor:
Tanja D. de Gruijl, Alfons J.M. van den Eertwegh, M. Petrousjka van den Tol, Rik J. Scheper, Paul A.M. van Leeuwen, Arnold Baars, Ronald J.C.L.M. Vuylsteke, Barbara G. Molenkamp, Berbel J.R. Sluijter, Mari F.C.M. van den Hout, Bas D. Koster
Recurrence-free survival of patients in the two separate trials.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce67ee79a38e9c40ee471447d8c551b
https://doi.org/10.1158/1078-0432.22466018.v1
https://doi.org/10.1158/1078-0432.22466018.v1
Autor:
Barbara G. Molenkamp, M. Petrousjka van den Tol, Ekaterina J. Jordanova, Rik J. Scheper, Berbel J.R. Sluijter, Paul A. M. van Leeuwen, Saskia Vosslamber, Marta López González, Alfons J. M. van den Eertwegh, Mari F. C. M. van den Hout, Bas D. Koster, Annelies W. Turksma, Tanja D. de Gruijl
Publikováno v:
Journal for Immunotherapy of Cancer, 9(3):e001962. BioMed Central
Koster, B D, López González, M, van den Hout, M F, Turksma, A W, Sluijter, B J, Molenkamp, B G, van Leeuwen, P A, Vosslamber, S, Scheper, R J, van den Eertwegh, A J, van den Tol, M P, Jordanova, E J & de Gruijl, T D 2021, ' T cell infiltration on local CpG-B delivery in early-stage melanoma is predominantly related to CLEC9A+CD141+ cDC1 and CD14+ antigen-presenting cell recruitment ', Journal for Immunotherapy of Cancer, vol. 9, no. 3, e001962 . https://doi.org/10.1136/jitc-2020-001962
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Koster, B D, López González, M, van den Hout, M F, Turksma, A W, Sluijter, B J, Molenkamp, B G, van Leeuwen, P A, Vosslamber, S, Scheper, R J, van den Eertwegh, A J, van den Tol, M P, Jordanova, E J & de Gruijl, T D 2021, ' T cell infiltration on local CpG-B delivery in early-stage melanoma is predominantly related to CLEC9A+CD141+ cDC1 and CD14+ antigen-presenting cell recruitment ', Journal for Immunotherapy of Cancer, vol. 9, no. 3, e001962 . https://doi.org/10.1136/jitc-2020-001962
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
BackgroundWe previously reported CpG-B injection at the primary tumor excision site prior to re-excision and sentinel node biopsy to result in immune activation of the sentinel lymph node (SLN), increased melanoma-specific CD8+ T cell rates in periph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c312d68369c6c83fe942376e1d4783
https://research.vumc.nl/en/publications/8d35bb60-3b28-48ad-a3a3-9c9238b47494
https://research.vumc.nl/en/publications/8d35bb60-3b28-48ad-a3a3-9c9238b47494