Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Barbara Enenkel"'
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145633 (2015)
The direct induction of cell death, or apoptosis, in target cells is one of the effector mechanisms for the anti CD20 antibody Rituximab. Here we provide evidence that Rituximab's apoptotic ability is linked to the antibody IgG isotype. Reformatting
Externí odkaz:
https://doaj.org/article/c97446b8eb9e495daed9f058cb7fa2ff
Autor:
Patrick Schulz, Joey Studts, Anne R. Karow, Stefan Hoerer, Tobias Litzenburger, Patrick Garidel, Barbara Enenkel, Daniel Seeliger, Julia Spitz, Michaela Blech
Publikováno v:
mAbs. 7(3)
The application of monoclonal antibodies as commercial therapeutics poses substantial demands on stability and properties of an antibody. Therapeutic molecules that exhibit favorable properties increase the success rate in development. However, it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97687fb7744e9ab8454f8f036a14e04f
https://pubmed.ncbi.nlm.nih.gov/25759214
https://pubmed.ncbi.nlm.nih.gov/25759214
Autor:
Barbara Enenkel, Mathias Knappenberger, Ingo Presser, Alexander Jacobi, Hitto Kaufmann, Christian Eckermann, Patrick Garidel
Publikováno v:
Handbook of Therapeutic Antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba40bc8d618ea069bd4aeb16cab4d71f
https://doi.org/10.1002/9783527682423.ch22
https://doi.org/10.1002/9783527682423.ch22
Autor:
Norbert Hauel, Ines Lauritsch, Bernd Guilliard, Andreas Schnapp, Iris Kauffmann, Joachim Lingner, Uwe M. Martens, Ulrike Hemmann, Christian Wenz, Barbara Enenkel, Claudia Niestroj, Wolfgang J. Rettig, Milena Pantic, Henning Priepke, Emanuelle Pascolo, Pilar Garin-Chesa, Norbert Kraut, Elfriede Müller, Gabriele Sauter, Klaus Damm, Christine Daiber
Publikováno v:
The EMBO Journal. 20:6958-6968
Telomerase, the ribonucleoprotein enzyme maintaining the telomeres of eukaryotic chromosomes, is active in most human cancers and in germline cells but, with few exceptions, not in normal human somatic tissues. Telomere maintenance is essential to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0544b5564a1a136e85e2b69aac70c7a
https://doi.org/10.1093/emboj/20.24.6958
https://doi.org/10.1093/emboj/20.24.6958
Autor:
Martin Lenter, Klaus Damm, John Edward Park, Wolfgang J. Rettig, Joachim Niedermeyer, Andreas Schnapp, Barbara Enenkel
Publikováno v:
European Journal of Biochemistry. 254:650-654
The human fibroblast-activation protein (FAP), a member of the serine protease family, was discovered as an inducible type-II cell-surface glycoprotein selectively expressed by reactive stromal fibroblasts of epithelial cancers and healing wounds. An
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86285fd77c4475b4a36bb3385fb1f4e5
https://doi.org/10.1046/j.1432-1327.1998.2540650.x
https://doi.org/10.1046/j.1432-1327.1998.2540650.x
Autor:
Hitto Kaufmann, Stefanos Grammatikos, Torsten W. Schulz, Helmut Hoffmann, Stefan Schlatter, Barbara Enenkel
Publikováno v:
Cells and Culture ISBN: 9789048134182
The majority of biopharmaceuticals is currently being expressed in mammalian cells, mostly Chinese hamster ovary (CHO) and mouse myeloma (NS0) cells. The two most prominent challenges for mammalian cell-based systems relate to (i) product titer in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0e3ab1b0bf2eb99ffeb596e395c6d2c
https://doi.org/10.1007/978-90-481-3419-9_62
https://doi.org/10.1007/978-90-481-3419-9_62
Publikováno v:
European Journal of Immunology. 21:659-663
By flow cytometry analysis we could show a decreased expression of Fc-gamma receptor type III (Fc-gamma-RIII) on granulocytes of a patient with systemic lupus erythematosus (SLE). Therefore, we constructed a leukocyte cDNA library from this patient w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e773a8ec12c9dea782ee30bb050dce
https://doi.org/10.1002/eji.1830210318
https://doi.org/10.1002/eji.1830210318
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0145633 (2015)
PLoS ONE, Vol 10, Iss 12, p e0145633 (2015)
The direct induction of cell death, or apoptosis, in target cells is one of the effector mechanisms for the anti CD20 antibody Rituximab. Here we provide evidence that Rituximab's apoptotic ability is linked to the antibody IgG isotype. Reformatting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b45b1ab71b327e5b5f5889a6d6ea72d
https://doi.org/10.1371/journal.pone.0145633
https://doi.org/10.1371/journal.pone.0145633
Publikováno v:
ESACT Proceedings ISBN: 1402027915
We have constructed dicistronic expression vectors for one-step antiapoptosis engineering and product expression. Expression units encoding the soluble intercellular adhesion molecule 1 (sICAM), a potential therapeutic for treatment of the common col
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::790a391bea2dfa8a538957cd838936e6
https://doi.org/10.1007/1-4020-3103-3_20
https://doi.org/10.1007/1-4020-3103-3_20
Publikováno v:
ESACT Proceedings ISBN: 1402027915
A major problem when establishing high-producing cell lines is the variability of integration sites. Integration of plasmid DNA into the genome of host cells occurs at random. As a consequence, selection of high producers is very time-consuming, cost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11d5ec3a2b6dedfa7d9ec607a72f53ff
https://doi.org/10.1007/1-4020-3103-3_165
https://doi.org/10.1007/1-4020-3103-3_165