Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Barbara E. Crute"'
Autor:
C. Ronald Kahn, Palle G. Laustsen, M. Dodson Michael, Kohjiro Ueki, Barbara E. Crute, Susanna R. Keller, Shmuel E. Cohen, Rohit N. Kulkarni, Gustav E. Lienhard
Publikováno v:
Genes & Development. 16:3213-3222
Based on the phenotypes of knockout mice and cell lines, as well as pathway-specific analysis, the insulin receptor substrates IRS-1, IRS-2, IRS-3, and IRS-4 have been shown to play unique roles in insulin signal transduction. To investigate possible
Autor:
Kari L. Hartman, John J. Kelley, Jianxia Shi, Yen-Yee Tang, Barbara E. Crute, John H. Bushweller, Jiangli Yan, Xuemei Huang, Thomas M. Laue, Nancy A. Speck
Publikováno v:
FEBS Letters. 470:167-172
Core binding factors (CBFs) play key roles in several developmental pathways and in human disease. CBFs consist of a DNA binding CBFalpha subunit and a non-DNA binding CBFbeta subunit that increases the affinity of CBFalpha for DNA. We performed sedi
Autor:
Nancy A. Speck, Chaohong Sun, Xuemei Huang, Kari L. Hartman, John H. Bushweller, Barbara E. Crute, Yen-Yee Tang, Amy F. Lewis, John J. Kelley, Thomas M. Laue
Publikováno v:
Journal of Biological Chemistry. 273:2480-2487
Core-binding factors (CBF) are heteromeric transcription factors essential for several developmental processes, including hematopoiesis. CBFs contain a DNA-binding CBF alpha subunit and a non-DNA binding CBF beta subunit that increases the affinity o
Publikováno v:
Journal of Biological Chemistry. 271:26251-26260
The Runt domain is the DNA-binding domain defining a small family of transcription factors that are involved in important developmental processes. Developmental pathways controlled by Runt domain proteins include sex determination, neurogenesis, segm
Autor:
Jane Widmer, Kate S. Wheeler, Samira Daniel, Ki-Han Kim, Joohun Ha, Nicole King, Susannah C. Schlichter, Nancy Nutile-McMenemy, Katherine S. Fassihi, Walter W. Noll, Lee A. Witters, Barbara E. Crute
Publikováno v:
Biochemical Journal. 316:915-922
Acetyl-CoA carboxylase (ACC), an important enzyme in fatty acid biosynthesis and a regulator of fatty acid oxidation, is present in at least two isoenzymic forms in rat and human tissues. Previous work has established the existence of a 265000 Da enz
Autor:
Qing Wang, Susanna R. Keller, Irena N Melnikova, Shuwen Wang, Barbara E. Crute, Nancy A. Speck
Publikováno v:
Molecular and Cellular Biology. 13:3324-3339
Moloney murine leukemia virus causes thymic leukemias when injected into newborn mice. A major determinant of the thymic disease specificity of Moloney virus genetically maps to the conserved viral core motif in the Moloney virus enhancer. Point muta
Publikováno v:
Journal of Tissue Culture Methods. 14:225-234
Microporous membranes support the differentiation of a variety of cell types including the Madin-Darby canine kidney (MDCK) cell line and normal human epidermal keratinocytes (NHEK). Coincident with culturing these cells on microporous membranes is a
Publikováno v:
Biological chemistry. 381(5-6)
AMP-activated protein kinase (AMPK) and cAMP-dependent protein kinase (cAMPK) have been reported to phosphorylate sites on phosphorylase kinase (PhK). Their target residues Ser 1018 and Ser 1020, respectively, are located in the so-called multi-phosp
Publikováno v:
The Journal of biological chemistry. 273(52)
The AMP-activated protein kinase is a heterotrimeric enzyme, important in cellular adaptation to the stress of nutrient starvation, hypoxia, increased ATP utilization, or heat shock. This mammalian enzyme is composed of a catalytic alpha subunit and
Publikováno v:
Journal of enzyme inhibition. 12(3)
Inhibition and substrate competition kinetics demonstrated that tRNA is a highly preferred substrate of thyroid alkaline RNase. The pyrimidine-specific RNase cleaved poly(C) 2.8 × 105 faster than poly(U). kcat: KM ratios for tRNA and poly(C) based o