Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Barbara E, Ehrlich"'
Autor:
Ryan Y. Nguyen, Hugh Xiao, Xiangyu Gong, Alfredo Arroyo, Aidan T. Cabral, Tom T. Fischer, Kaitlin M. Flores, Xuchen Zhang, Marie E. Robert, Barbara E. Ehrlich, Michael Mak
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Treatment for liver cancer is complicated by its various subtypes, which show different responses to anticancer drugs. This study demonstrates the effectiveness of targeting biophysical phenotypes related to cytoskeleton properties that are usually m
Externí odkaz:
https://doaj.org/article/61f6dcee595e4f84a582f13e316a2289
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-16 (2021)
Abstract Background After chemotherapy, many cancer survivors suffer from long-lasting cognitive impairment, colloquially known as “chemobrain.” However, the trajectories of cognitive changes and the underlying mechanisms remain unclear. We previ
Externí odkaz:
https://doaj.org/article/5625476c5c6e44dfbbb57f40d1aed73e
Autor:
Lien D. Nguyen, Luca G. Nolte, Winston J. T. Tan, Denise Giuvelis, Joseph Santos-Sacchi, Edward Bilsky, Barbara E. Ehrlich
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Neuronal calcium sensor 1 (NCS1) regulates a wide range of cellular functions throughout the mammalian nervous systems. Altered NCS1 expression is associated with neurodevelopmental and neurodegenerative diseases. Previous studies focused on
Externí odkaz:
https://doaj.org/article/b6b8f1fb46154bcdb198d9beb1bac578
Publikováno v:
Frontiers in Pain Research, Vol 3 (2022)
Chemotherapy induced peripheral neuropathy (CIPN) is an often severe and debilitating complication of multiple chemotherapeutic agents that can affect patients of all ages, across cancer diagnoses. CIPN can persist post-therapy, and significantly imp
Externí odkaz:
https://doaj.org/article/5bb01bcf41ef441393fdcefd991cdfdf
Publikováno v:
Molecular Oncology, Vol 14, Iss 6, Pp 1134-1151 (2020)
Changes in intracellular calcium (Ca2+) signaling can modulate cellular machinery required for cancer progression. Neuronal calcium sensor 1 (NCS1) is a ubiquitously expressed Ca2+‐binding protein that promotes tumor aggressiveness by enhancing cel
Externí odkaz:
https://doaj.org/article/720596b58db84d30b843d6598f2e2451
Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases
Autor:
Lien D Nguyen, Barbara E Ehrlich
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 6, Pp 1-17 (2020)
Abstract Chemotherapy is a life‐saving treatment for cancer patients, but also causes long‐term cognitive impairment, or “chemobrain”, in survivors. However, several challenges, including imprecise diagnosis criteria, multiple confounding fac
Externí odkaz:
https://doaj.org/article/4554494c24544e7e82d958a843d63a64
Autor:
Eiman Y Ibrahim, Saira Munshani, Ilaria Domenicano, Rozalyn Rodwin, Richard J Nowak, Lajos Pusztai, Maryam Lustberg, Barbara E Ehrlich
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0275648 (2022)
Dramatic improvements in cancer survival have occurred in the last decade, but the quality of life for many survivors is compromised due to severe, long-lasting, and often irreversible side effects of chemotherapy. The neurological side effects, chem
Externí odkaz:
https://doaj.org/article/f48d6fc653604f6fa92affdc86a675ee
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Wolfram Syndrome is a rare autosomal recessive disease characterized by early-onset diabetes mellitus, neurodegeneration, and psychological disorders. Mutations in the gene WFS1, coding for the protein wolframin, cause Wolfram Syndrome and are associ
Externí odkaz:
https://doaj.org/article/7ba8c7d7d1264152bae926f25e6b4846
Autor:
Malika Arhatte, Gihan S. Gunaratne, Charbel El Boustany, Ivana Y. Kuo, Céline Moro, Fabrice Duprat, Magali Plaisant, Hélène Duval, Dahui Li, Nicolas Picard, Anais Couvreux, Christophe Duranton, Isabelle Rubera, Sophie Pagnotta, Sandra Lacas-Gervais, Barbara E. Ehrlich, Jonathan S. Marchant, Aaron M. Savage, Fredericus J. M. van Eeden, Robert N. Wilkinson, Sophie Demolombe, Eric Honoré, Amanda Patel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Polycystin-2 (PC2) is an ion channel commonly found mutated in autosomal dominant polycystic kidney disease. Here Arhatte et al. identify transmembrane protein 33 (TMEM33) as a regulator of PC2 function at the endoplasmic reticulum, and find that del
Externí odkaz:
https://doaj.org/article/a10e8cca0f764891af20836abbb4891c
Autor:
Eiman Y. Ibrahim, Ilaria Domenicano, Kate Nyhan, Mohamed Elfil, Sarah S. Mougalian, Brenda Cartmel, Barbara E. Ehrlich
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Purpose: This meta-analysis provides a longitudinal assessment of depression and cognitive impairment induced by taxane-based chemotherapy in women with breast cancer after 6 months of treatment. We highlighted the incidence and prevalence, the cogni
Externí odkaz:
https://doaj.org/article/6484326be758473fbcf0a76d48a68382