Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Barbara Deschler"'
Autor:
Barbara Deschler-Baier, Markus Krebs, Matthias Kroiss, Manik Chatterjee, Daniel Gundel, Christian Kestler, Alexander Kerscher, Volker Kunzmann, Silke Appenzeller, Katja Maurus, Andreas Rosenwald, Ralf Bargou, Elena Gerhard-Hartmann, Vivek Venkataramani
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-6 (2024)
Abstract This case report describes the efficacy of selpercatinib, a selective RET inhibitor, in an unusual case of large-cell neuroendocrine pancreatic carcinoma (LCNEPAC) harboring a CCDC6::RET fusion. A 56-year-old male with a history of multiple
Externí odkaz:
https://doaj.org/article/506d531186bd4f8ab0f4e6ef49c5a07e
Autor:
Chia-Chi Lin, Elena Garralda, Patrick Schöffski, David S. Hong, Lillian L. Siu, Miguel Martin, Michela Maur, Rina Hui, Ross A Soo, Joanne Chiu, Tian Zhang, Brigette Ma, Chrisann Kyi, Daniel SW Tan, Philippe A. Cassier, John Sarantopoulos, Andrew Weickhardt, Richard D. Carvajal, Jennifer Spratlin, Taito Esaki, Fréderic Rolland, Wallace Akerley, Barbara Deschler-Baier, Lawrence Rispoli, Tanay S. Samant, Niladri Roy Chowdhury, Daniel Gusenleitner, Eunice L. Kwak, Vasileios Askoxylakis, Filippo De Braud
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTIeramilimab, a humanized anti-LAG-3 monoclonal antibody, was well tolerated in combination with the anti-PD-1 antibody spartalizumab in a phase 1 study. This phase 2 study aimed to further investigate the efficacy and safety of combination tr
Externí odkaz:
https://doaj.org/article/fba32163599d40e7abcb0008f2589a1a
Autor:
Tian Zhang, Filippo de Braud, Taito Esaki, Wallace Akerley, Chrisann Kyi, Richard D Carvajal, Daniel Gusenleitner, Patrick Schöffski, Miguel Martin, David S Hong, Amy Prawira, Jürgen Krauß, Nidhi Patel, Rina Hui, Andrew Weickhardt, Niladri Roy Chowdhury, Daniel S W Tan, María Ochoa-de-Olza, John Sarantopoulos, Ross A Soo, Michela Maur, Barbara Deschler-Baier, Allen Lau, Tanay S Samant, Tyler Longmire, Catherine A Sabatos-Peyton, Radha Ramesh, Tiancen Hu, Ana Carion, Padmaja Yerramilli-Rao, Vasileios Askoxylakis, Eunice L Kwak
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 2 (2022)
Background Lymphocyte-activation gene 3 (LAG-3) is an inhibitory immunoreceptor that negatively regulates T-cell activation. This paper presents preclinical characterization of the LAG-3 inhibitor, ieramilimab (LAG525), and phase I data for the treat
Externí odkaz:
https://doaj.org/article/c14ae2c468844f0d8af45992b1b6b8f2
Publikováno v:
Medikamentöse Tumortherapie von Kopf-Hals-Tumoren ISBN: 9783662628072
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9abdec0ce71236b3f91b68f8d54acfb
https://doi.org/10.1007/978-3-662-62808-9_11
https://doi.org/10.1007/978-3-662-62808-9_11
Autor:
Anna Kostenko, Enriqueta Felip, Bianca van Veggel, Ruth Seggewiss-Bernhardt, Jürgen Wolf, Stefan Haneder, Reinhard Büttner, Vanessa Rüsseler, Eva Geissinger, Johannes Brägelmann, Andreas Rosenwald, Jan Stratmann, Michael Puesken, Matthias Scheffler, Michaela Angelika Ihle, Rieke Fischer, Egbert F. Smit, Martin L. Sos, N. Pardo, Frank Griesinger, Sabine Merkelbach-Bruse, Sebastian Michels, Andreas H. Scheel, Susanne Steinhauser, Hans-Georg Kopp, Lucia Nogova, Ernst Rodermann, Barbara Deschler-Baier, Alex Martinez-Marti, Jana Fassunke, Martin Hellmich, Thorsten Persigehl, Martin Sebastian, Adrianus J. de Langen, Werner Spengler, Carina Heydt, Kim Monkhorst, Walburga Engel-Riedel, Dennis Plenker, Joachim Diebold, Lukas C. Heukamp, Bart Vrugt, Oliver Gautschi
Publikováno v:
JCO Precision Oncology
PURPOSE Third-generation epidermal growth factor receptor ( EGFR) tyrosine kinase inhibitors (TKIs) are effective in acquired resistance (AR) to early-generation EGFR TKIs in EGFR-mutant lung cancer. However, efficacy is marked by interindividual het
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5cbf4943cb5cf52a50137e024f7f69
https://doi.org/10.1200/po.18.00210
https://doi.org/10.1200/po.18.00210
Autor:
Natalie Hasenauer, Takahiro Higuchi, Barbara Deschler-Baier, Philipp E. Hartrampf, Martin G. Pomper, Steven P. Rowe, Martin Fassnacht, Andreas K. Buck, Rudolf A. Werner
Publikováno v:
Clinical Nuclear Medicine. 47:651-652
We present the case of a 60-year-old man with medullary thyroid carcinoma and hepatic, osseous, and lymph node metastases who underwent peptide receptor radionuclide therapy with 177Lu-DOTATOC. After 2 cycles, 68Ga-DOTATOC PET/CT revealed multiple no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a79e9511a4760d9cb6ebbcac562954
https://doi.org/10.1097/rlu.0000000000004082
https://doi.org/10.1097/rlu.0000000000004082
Autor:
Jonas Kuon, Christian Schulz, Michael Bitzer, Claus Peter Heußel, Jürgen Fischer, Barbara Deschler-Baier, Michael Schultheiß, Jan Leipe, Niels Reinmuth, Justyna Rawluk
Publikováno v:
DMW - Deutsche Medizinische Wochenschrift. 144:346-353
The immune oncological treatment approach uses immune checkpoint inhibitors to prevent tumor cells from shutting down the immune system, and thus from escaping immune response. Following the clinical success of immune checkpoint inhibitors, the numbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98a2c160de1306eff3c6aa6911e72b7f
https://doi.org/10.1055/a-0739-8194
https://doi.org/10.1055/a-0739-8194
Autor:
Barbara Deschler, Gabriele Ihorst, Uwe Platzbecker, Ulrich Germing, Eva März, Marcelo de Figuerido, Kurt Fritzsche, Peter Haas, Helmut R. Salih, Aristoteles Giagounidis, Dominik Selleslag, Boris Labar, Theo de Witte, Pierre Wijermans, Michael Lübbert
Publikováno v:
Haematologica, Vol 98, Iss 2 (2013)
Myelodysplastic syndromes and acute myeloid leukemia exemplify the complexity of treatment allocation in older patients as options range from best supportive care, non-intensive treatment (e.g. hypomethylating agents) to intensive chemotherapy/hemato
Externí odkaz:
https://doaj.org/article/481c53ccfa084c9aa1ee854ebad57e2d
Autor:
Horst-Dieter, Hummel, Peter, Kufer, Carsten, Grüllich, Ruth, Seggewiss-Bernhardt, Barbara, Deschler-Baier, Manik, Chatterjee, Maria-Elisabeth, Goebeler, Kurt, Miller, Maria, de Santis, Wolfgang, Loidl, Christian, Dittrich, Andreas, Buck, Constantin, Lapa, Annette, Thurner, Sabine, Wittemer-Rump, Gökben, Koca, Oliver, Boix, Wolf-Dietrich, Döcke, Ricarda, Finnern, Helena, Kusi, Antoinette, Ajavon-Hartmann, Sabine, Stienen, Cyrus Michael, Sayehli, Bülent, Polat, Ralf C, Bargou
Publikováno v:
Immunotherapy. 13(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::57a1aa0c33b004916ae6499cae348821
https://pubmed.ncbi.nlm.nih.gov/33172323
https://pubmed.ncbi.nlm.nih.gov/33172323
Autor:
Patrick Schöffski, Miguel Martin, Rich Carvajal, Chrisann Kyi, Joanne Chiu, Tian Zhang, Filippo de Braud, Lillian L. Siu, Philippe A. Cassier, Ross A. Soo, Catherine Anne Sabatos-Peyton, Niladri Roy Chowdhury, Taito Esaki, John Sarantopoulos, Daniel Tan, Jennifer L. Spratlin, Michela Maur, Brigette B.Y. Ma, Daniel Gusenleitner, Vasileios Askoxylakis, Rina Hui, Andrew Weickhardt, Eunice Kwak, David S. Hong, Frederic Rolland, Elena Garralda, Barbara Deschler-Baier, Chia-Chi Lin, Wallace Akerley
Publikováno v:
Regular and young investigator award abstracts.
Background Expression of LAG-3, an inhibitory immunoreceptor, has been linked to reduced T-cell proliferation and cytokine production. LAG525 is a humanized IgG4 anti-LAG-3 antibody which inhibits LAG-3 binding to MHC class II. Spartalizumab is a hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bf44e2ab28630c9f613e531988f010b
https://doi.org/10.1136/jitc-2020-sitc2020.0387
https://doi.org/10.1136/jitc-2020-sitc2020.0387