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pro vyhledávání: '"Barbara D.C. Pacheco"'
Autor:
Sergio Pinheiro, Estela M.F. Muri, Barbara D.C. Pacheco, Luciano Puzer, Bruno E.G. de Souza, Mariana B.M. de Moraes, Rafael Garrett, Luiza R.S. Dias, Camilo Henrique da Silva Lima, Acácio S. de Souza
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1094-1098
Human kallikreins 5 and 7 (KLK5 and KLK7) exhibit trypsin- and chymotrypsin-like activities and are involved in pathologies related to skin desquamation process. A series of new 3-acyltetramic acids were developed as a novel class of inhibitors of KL