Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Barbara D. Brown"'
Publikováno v:
Drug Development Research. 5:251-259
The mechanism of therapeutic action of antidepressant drugs has been related to their effects on metabolism and release and reuptake of catecholamines and serotonin. Some atypical antidepressants, however, do not have such pharmacological effects. Re
Publikováno v:
Journal of Neuropathology and Experimental Neurology. 30:525-535
Autor:
Barbara D. Brown, Eric G. Brunngraber
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Specialized Section on Mucoproteins and Mucopolysaccharides. 83:357-360
Publikováno v:
Journal of Neurochemistry. 22:125-128
— The dialysableglycopeptide preparation recovered from the glycoproteins in cerebral gray matter of a case of the O-variant form of GM2 gangliosidosis contained four fold more N-acetylglucosamine and mannose than a similar preparation from normal
Autor:
Eric G. Brunngraber, Barbara D. Brown
Publikováno v:
Biochemical Journal. 103:65-72
Sialomucopolysaccharides were released from the defatted protein residue by the proteolytic action of papain after extraction of rat whole brains with chloroform–methanol (2:1, v/v). Further purification is achieved by dialysis to remove low-molecu
Publikováno v:
Journal of Neurochemistry. 16:1059-1070
— Glycoproteins in brain tissue were assayed by determining the amount of N-acetylneuraminic acid (NANA), hexosamine, hexose, and fucose present in glycopeptides released by the proteolytic action of papain on the defatted protein residue that rema
Publikováno v:
Acta Neuropathologica. 24:43-55
The white matter in 4 cases of $${\text{G}}_{{\text{M}}_{\text{2}} } $$ gangliosidosis was studied with particular regard to the question of a primary versus secondary character of myelin alteration. Histopathologically, the cases were characterized
Publikováno v:
Brain Research. 38:151-162
The concentration of N-acetylneuraminic acid (NANA) in the non-dialyzable and dialyzable glycopeptides derived from Tay-Sachs brain tissue was the same as that found in normal controls. This suggests that the heteropolysaccharide chains of the brain
Publikováno v:
Clinica Chimica Acta. 32:159-170
A procedure is described which permits the determination of gangliosides, glycoproteins, and glycosaminoglycans in brain tissue samples. Gangliosides are extracted with chloroform-methanol (2:1 and 1:2, v/v). The defatted tissue is treated with papai
Publikováno v:
Biochemical Journal. 103:73-78
Protein-bound N-acetylneuraminic acid and hexosamine, including the sialomucopolysaccharides, occur mainly in the least dense particles sedimented in the microsomal fraction from rat whole brain. Particles rich in protein-bound N-acetylneuraminic aci