Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Barbara Clough"'
Autor:
Elizabeth M. Darby, Robert A. Moran, Emma Holden, Theresa Morris, Freya Harrison, Barbara Clough, Ross S. McInnes, Ludwig Schneider, Eva M. Frickel, Mark A. Webber, Jessica M. A. Blair
Publikováno v:
mSphere, Vol 9, Iss 5 (2024)
ABSTRACT The two species that account for most cases of Acinetobacter-associated bacteremia in the United Kingdom are Acinetobacter lwoffii, often a commensal but also an emerging pathogen, and Acinetobacter baumannii, a well-known antibiotic-resista
Externí odkaz:
https://doaj.org/article/8d374d5b7f504bbaa70c039e941064e4
Autor:
Barbara Clough, Daniel Fisch, Todd H. Mize, Vesela Encheva, Ambrosius Snijders, Eva-Maria Frickel
Publikováno v:
mSphere, Vol 8, Iss 6 (2023)
ABSTRACTInfection with the parasite Toxoplasma gondii leads to production of interferon gamma (IFNγ) that stimulates cells to upregulate defense proteins targeting the parasite for cell intrinsic elimination or growth restriction. Various host defen
Externí odkaz:
https://doaj.org/article/895407d7e0a14877a13c4bbd2aa74765
Autor:
Artur Yakimovich, Moona Huttunen, Jerzy Samolej, Barbara Clough, Nagisa Yoshida, Serge Mostowy, Eva-Maria Frickel, Jason Mercer
Publikováno v:
mSphere, Vol 5, Iss 5 (2020)
ABSTRACT The use of deep neural networks (DNNs) for analysis of complex biomedical images shows great promise but is hampered by a lack of large verified data sets for rapid network evolution. Here, we present a novel strategy, termed “mimicry embe
Externí odkaz:
https://doaj.org/article/d26b0508dfde4b1581e6233c5ef9daa5
Autor:
Daniel Fisch, Barbara Clough, Marie-Charlotte Domart, Vesela Encheva, Hironori Bando, Ambrosius P. Snijders, Lucy M. Collinson, Masahiro Yamamoto, Avinash R. Shenoy, Eva-Maria Frickel
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108008- (2020)
Summary: Interferon-inducible guanylate-binding proteins (GBPs) promote cell-intrinsic defense through host cell death. GBPs target pathogens and pathogen-containing vacuoles and promote membrane disruption for release of microbial molecules that act
Externí odkaz:
https://doaj.org/article/fcd45fd07738483588df111dbf4ade5d
Publikováno v:
PLoS Pathogens, Vol 15, Iss 12, p e1008097 (2019)
Externí odkaz:
https://doaj.org/article/d4f6c021209341af9dcfd67c37fabef4
Autor:
Clémence Foltz, Anna Napolitano, Rabia Khan, Barbara Clough, Elizabeth M. Hirst, Eva-Maria Frickel
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Interferon gamma (IFNγ) is the major proinflammatory cytokine conferring resistance to the intracellular vacuolar pathogen Toxoplasma gondii by inducing the destruction of the parasitophorous vacuole (PV). We previously identified TRIM21 as
Externí odkaz:
https://doaj.org/article/166b4c5cdada44f58f4e8b6bf0980473
Autor:
Barbara Clough, Ryan Finethy, Rabia T. Khan, Daniel Fisch, Sarah Jordan, Harshil Patel, Jörn Coers, Eva-Maria Frickel
Publikováno v:
Wellcome Open Research, Vol 4 (2019)
Background: Infections cause the production of inflammatory cytokines such as Interferon gamma (IFNγ). IFNγ in turn prompts the upregulation of a range of host defence proteins including members of the family of guanylate binding proteins (Gbps). I
Externí odkaz:
https://doaj.org/article/4b6a1ef71eb04f5688dc8cf72c9cb390
Autor:
Daniel Fisch, Artur Yakimovich, Barbara Clough, Joseph Wright, Monique Bunyan, Michael Howell, Jason Mercer, Eva Frickel
Publikováno v:
eLife, Vol 8 (2019)
For image-based infection biology, accurate unbiased quantification of host–pathogen interactions is essential, yet often performed manually or using limited enumeration employing simple image analysis algorithms based on image segmentation. Host p
Externí odkaz:
https://doaj.org/article/cb3b59b452414be8bbcd1e4ed81860ca
Autor:
Barbara Clough, Joseph D Wright, Pedro M Pereira, Elizabeth M Hirst, Ashleigh C Johnston, Ricardo Henriques, Eva-Maria Frickel
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1006027 (2016)
Toxoplasma gondii is the most common protozoan parasitic infection in man. Gamma interferon (IFNγ) activates haematopoietic and non-haematopoietic cells to kill the parasite and mediate host resistance. IFNγ-driven host resistance pathways and para
Externí odkaz:
https://doaj.org/article/8bd094515d0e4dd492c093e2f5136e10
Publikováno v:
Pathogens and Disease
Human guanylate binding proteins (GBPs) are key players of interferon–gamma (IFNγ)-induced cell intrinsic defense mechanisms targeting intracellular pathogens. In this study, we combine the well-established Toxoplasmagondii infection model with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d747faeaf02d8fe3897ce1befab5eee7
