Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Barbara Chie-Leon"'
Autor:
Matthew Jones, Philipp Grosche, Andreas Floersheimer, Jérome André, Raphael Gattlen, Dieter Oser, Juliette Tinchant, Roman Wille, Barbara Chie-Leon, Marc Gerspacher, Peter Ertl, Nils Ostermann, Eva Altmann, Eusebio Manchado, Thomas Vorherr, Patrick Chène
Publikováno v:
Biochemistry. 62:1321-1329
Autor:
Jonathan Solomon, Simone Bonazzi, Eva d'Hennezel, Rohan Beckwith, Lei Xu, Aleem Fazal, Anna Magracheva, Radha Ramesh, Artiom Cernijenko, Brandon Antonakos, Hyo-eun Bhang, Roxana Garcia Caro, Jennifer Cobb, Elizabeth Ornelas, Xiaolei Ma, Charles Wartchow, Matt Clifton, Ry Forseth, Bethany Fortnam, Hongbo Lu, Alfredo Csibi, Jennifer Tullai, Seth Carbonneau, Noel Thomsen, Jay Larrow, Barbara Chie-Leon, Dominik Hainzl, Yi Gu, Darlene Lu, Matthew Meyer, Dylan Alexander, Jacqueline Kinyamu-Akunda, Catherine Sabatos-Peyton, Natalie Dales, Frederic Zecri, Rishi Jain, Janine Shulok, Y. Karen Wang, Karin Briner, Jeffrey Porter, John Tallarico, Jeffrey Engelman, Glenn Dranoff, Jay Bradner, Michael Visser
Growing malignant tumors must evade destruction by the immune system, a hurdle some malignancies overcome by attracting immune-suppressive regulatory T-cells (Tregs)1. The IKZF2 (Helios) transcription factor plays a crucial role in maintaining functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e91b1b99fea2c930f908b107802a0e27
https://doi.org/10.21203/rs.3.rs-1531006/v1
https://doi.org/10.21203/rs.3.rs-1531006/v1
Autor:
Simone Bonazzi, Eva d’Hennezel, Rohan E.J. Beckwith, Lei Xu, Aleem Fazal, Anna Magracheva, Radha Ramesh, Artiom Cernijenko, Brandon Antonakos, Hyo-eun C. Bhang, Roxana García Caro, Jennifer S. Cobb, Elizabeth Ornelas, Xiaolei Ma, Charles A. Wartchow, Matthew C. Clifton, Ry R. Forseth, Bethany Hughes Fortnam, Hongbo Lu, Alfredo Csibi, Jennifer Tullai, Seth Carbonneau, Noel M. Thomsen, Jay Larrow, Barbara Chie-Leon, Dominik Hainzl, Yi Gu, Darlene Lu, Matthew J. Meyer, Dylan Alexander, Jacqueline Kinyamu-Akunda, Catherine A. Sabatos-Peyton, Natalie A. Dales, Frédéric J. Zécri, Rishi K. Jain, Janine Shulok, Y. Karen Wang, Karin Briner, Jeffery A. Porter, John A. Tallarico, Jeffrey A. Engelman, Glenn Dranoff, James E. Bradner, Michael Visser, Jonathan M. Solomon
Publikováno v:
Cell Chemical Biology. 30:235-247.e12
Autor:
Ramadevi Prathapam, Alexandra Frommlet, Jacob Shaul, Dita M. Rasper, Xiaoyu Shen, Alexey Ruzin, Sharadha Subramanian, Feng Wang, Micah Steffek, Bret Benton, Jason Vo, Steven Shia, Wooseok Han, Andreas O. Frank, Charles Wartchow, Patrick Lee, Xiaolei Ma, Fergal Casey, Hanne Merritt, Carl J. Balibar, Alun Bermingham, Elizabeth Ornelas, Tsuyoshi Uehara, Andreas Lingel, Chi-Min Ho, Barbara Chie-Leon, William S. Sawyer, Min-Kyu Cho, Sylvia Ma, Katherine R Prosen, Min Li, Christopher M. Rath, Gianfranco De Pascale
Publikováno v:
Journal of the American Chemical Society. 142:4445-4455
The lipopolysaccharide biosynthesis pathway is considered an attractive drug target against the rising threat of multi-drug-resistant Gram-negative bacteria. Here, we report two novel small-molecule inhibitors (compounds 1 and 2) of the acyltransfera
Autor:
Xiaolei, Ma, Ramadevi, Prathapam, Charles, Wartchow, Barbara, Chie-Leon, Chi-Min, Ho, Javier, De Vicente, Wooseok, Han, Min, Li, Yipin, Lu, Savithri, Ramurthy, Steven, Shia, Micah, Steffek, Tsuyoshi, Uehara
Publikováno v:
ACS infectious diseases. 6(6)
LpxD, acyl-ACP-dependent
Autor:
Philip P Chamberlain, Maria Wang, Yoshinori Hirano, Brian E. Cathers, Gilles Carmel, Toshio Hakoshima, Hiroshi Handa, Barbra Pagarigan, Emily Rychak, Yan J Ren, Barbara Chie-Leon, Silvia L. Delker, Laura G. Corral, Tomoyuki Mori, Takumi Ito, Thomas O. Daniel, Antonia Lopez-Girona, Karen Miller, Hideki Ando, Mariko Riley
Publikováno v:
Nature Structural & Molecular Biology. 21:803-809
The Cul4-Rbx1-DDB1-Cereblon E3 ubiquitin ligase complex is the target of thalidomide, lenalidomide and pomalidomide, therapeutically important drugs for multiple myeloma and other B-cell malignancies. These drugs directly bind Cereblon (CRBN) and pro
Autor:
Vicki L. Nienaber, John Badger, Barbara Chie-Leon, Vandana Sridhar, Michael I. Recht, Francisco E. Torres, Leslie Hernandez
Publikováno v:
SLAS Discovery. 17:469-480
Fragment-based screening has typically relied on X-ray or nuclear magnetic resonance methods to identify low-affinity ligands that bind to therapeutic targets. These techniques are expensive in terms of material and time, so it useful to have a highe
Autor:
Peter H. Zwart, Barbara Chie-Leon, John Badger, Cheyenne Logan, Vicki L. Nienaber, Banumathi Sankaran, Vandana Sridhar
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 67:749-752
LpxD is a bacterial protein that is part of the biosynthesis pathway of lipid A and is responsible for transferring 3-hydroxymyristic acid from the R-3-hydroxymyristoyl-acyl carrier protein to the 2-OH group of UDP-3-O-(3-hydroxymyristoyl) glucosamin
Autor:
Pierre-Yves Bounaud, Barbara Chie-Leon, Vicki L. Nienaber, Vandana Sridhar, John Badger, Francisco E. Torres, Cheyenne Logan, Michael I. Recht
Publikováno v:
Journal of biomolecular screening. 19(4)
Fragment-based lead discovery (FBLD) is a technique in which, small, low-complexity chemical fragments of 6 to 15 heavy atoms are screened for binding to or inhibiting activity of the target. Hits are then linked and/ or elaborated into tightly bindi
Autor:
Cheyenne Logan, Barbara Chie-Leon, Banumathi Sankaran, Peter H. Zwart, Vicki L. Nienaber, John Badger, Vandana Sridhar
Publikováno v:
Acta crystallographica. Section F, Structural biology and crystallization communications. 69(Pt 1)
Acinetobacter baumannii is a Gram-negative pathogenic bacterium which is resistant to most currently available antibiotics and that poses a significant health threat to hospital patients. LpxA is a key enzyme in the biosynthetic pathway of the lipopo